M Shadab Siddiqui,Richard K Sterling
M Shadab Siddiqui
Metabolic syndrome (MS) is a cluster of metabolic derangements associated with insulin resistance and an increased risk of cardiovascular mortality. MS has become a major health concern worldwide and is considered to be the etiology of the ...
Marilena Durazzo,Paola Belci,Alessandro Collo et al.
Marilena Durazzo et al.
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world (it affects 30% of the general adult population). The NAFLD encompasses a histological spectrum ranging from simple steatosis to nonalcoh...
Biomarkers in liver disease: emerging methods and potential applications [0.03%]
肝病的生物标志物：新兴的方法和潜在应用
Guruprasad P Aithal,Neil Guha,Jonathan Fallowfield et al.
Guruprasad P Aithal et al.
Nir Hilzenrat,Averell H Sherker
Nir Hilzenrat
The nude mouse as model for liver deficiency study and treatment and xenotransplantation [0.03%]
裸鼠肝肾阴虚模型及其异种移植研究
Isabelle Vidal,Lysiane Richert
Isabelle Vidal
We aimed at reviewing the various uses of Nude mouse for the development of liver deficiency models and evaluation of efficacy of hepatic cell xenotransplantation. The first part records the large range of liver deficiency models that can b...
Hepatocytes polyploidization and cell cycle control in liver physiopathology [0.03%]
肝多倍体化和肝细胞周期控制在肝脏生理病理中的作用
Géraldine Gentric,Chantal Desdouets,Séverine Celton-Morizur
Géraldine Gentric
Most cells in mammalian tissues usually contain a diploid complement of chromosomes. However, numerous studies have demonstrated a major role of "diploid-polyploid conversion" during physiopathological processes in several tissues. In the l...
A current review of the diagnostic and treatment strategies of hepatic encephalopathy [0.03%]
肝性脑病诊断和治疗策略的现状及评述
Z Poh,P E J Chang
Z Poh
Hepatic encephalopathy (HE) is a serious and potentially fatal complication in patients with cirrhotic liver disease. It is a spectrum ranging from minimal hepatic encephalopathy (MHE) without recognizable clinical symptoms or signs, to ove...
The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control [0.03%]
MAPK MEK1/2-ERK1/2信号转导通路及其在肝细胞周期调控中的作用研究
Jean-Philippe Guégan,Christophe Frémin,Georges Baffet
Jean-Philippe Guégan
Primary cultures of hepatocytes are powerful models in studying the sequence of events that are necessary for cell progression from a G0-like state to S phase. The models mimic the physiological process of hepatic regeneration after liver i...
Combined Stimulation with the Tumor Necrosis Factor α and the Epidermal Growth Factor Promotes the Proliferation of Hepatocytes in Rat Liver Cultured Slices [0.03%]
肿瘤坏死因子α与表皮生长因子联合刺激促进培养的大鼠肝切片中 hepatocyte 增殖
Francis Finot,Régis Masson,Fabienne Desmots et al.
Francis Finot et al.
The culture liver slices are mainly used to investigate drug metabolism and xenobiotic-mediated liver injuries while apoptosis and proliferation remain unexplored in this culture model. Here, we show a transient increase in LDH release and ...
Isabelle Garcin,Thierry Tordjmann
Isabelle Garcin
After partial hepatectomy (PH) the initial mass of the organ is restored through a complex network of cellular interactions that orchestrate both proliferative and hepatoprotective signalling cascades. Among agonists involved in this networ...