PBC: Animal Models of Cholangiopathies and Possible Endogenous Viral Infections [0.03%]
PBC：胆管病的动物模型及其可能的内源性病毒感染
Masashi Ninomiya,Yoshiyuki Ueno,Tooru Shimosegawa
Masashi Ninomiya
Primary Biliary Cirrhosis (PBC) is considered an autoimmune disease characterized by immune-mediated destruction of the intrahepatic bile ducts and its characteristic serologic marker, the anti-mitochondrial antibody (AMA). Several factors ...
Caroli's Disease: Current Knowledge of Its Biliary Pathogenesis Obtained from an Orthologous Rat Model [0.03%]
胆道卡罗利病的胆道发病机制的 current knowledge 及其 rat 模型研究进展
Yasunori Sato,Xiang Shan Ren,Yasuni Nakanuma
Yasunori Sato
Caroli's disease belongs to a group of hepatic fibropolycystic diseases and is a hepatic manifestation of autosomal recessive polycystic kidney disease (ARPKD). It is a congenital disorder characterized by segmental saccular dilatations of ...
Hepatitis C virus e2 protein ectodomain is essential for assembly of infectious virions [0.03%]
丙型肝炎病毒E2蛋白胞外区是产生感染性病毒颗粒的必要条件
Alessia Bianchi,Stefania Crotta,Michela Brazzoli et al.
Alessia Bianchi et al.
The Hepatitis C virus E1 and E2 envelope proteins are the major players in all events required for virus entry into target cells. In addition, the recently developed HCV cell culture system has indicated that E1E2 heterodimer formation is a...
APASL and AASLD Consensus Guidelines on Imaging Diagnosis of Hepatocellular Carcinoma: A Review [0.03%]
亚太肝脏研究学会和美国肝病研究学会关于 hepatocellular carcinoma 影像诊断共识指南的解读
Cher Heng Tan,Su-Chong Albert Low,Choon Hua Thng
Cher Heng Tan
Consensus guidelines for radiological diagnosis of hepatocellular carcinoma (HCC) have been drafted by several large international working groups. This article reviews the similarities and differences between the most recent guidelines prop...
Chronic elevation of liver enzymes in acute intermittent porphyria initially misdiagnosed as autoimmune hepatitis [0.03%]
急性间歇性_porphyria_患者长期肝酶升高初期误诊为自身免疫性肝炎
A González Estrada,S García-Morillo,L Gómez Morales et al.
A González Estrada et al.
Autoimmune hepatitis is a disease characterized by an elevation of liver enzymes, as well as specific autoantibodies. It is more common in women than men. We describe a 32-year-old woman with elevated transaminases, autoantibodies, and a li...
Assessment of stromal invasion for correct histological diagnosis of early hepatocellular carcinoma [0.03%]
评估癌性干细胞浸润以正确地对极早期肝细胞肝癌进行组织学诊断
Fukuo Kondo
Fukuo Kondo
Stromal invasion (invasive growth of tumor tissue into portal tracts and fibrous septa) is now recognized as the most important finding in the diagnosis of the well-differentiated type of early hepatocellular carcinomas (HCCs). In different...
Vibha Varma,Naimish Mehta,Vinay Kumaran et al.
Vibha Varma et al.
Patients with chronic liver disease and certain patients with acute liver failure require liver transplantation as a life-saving measure. Liver transplantation has undergone major improvements, with better selection of candidates for transp...
Yasuni Nakanuma,Anthony J Demetris,Yoshiyuki Ueno et al.
Yasuni Nakanuma et al.
Kenichi Harada,Yasuni Nakanuma
Kenichi Harada
Biliary innate immunity is involved in the pathogenesis of cholangiopathies in cases of biliary disease. Cholangiocytes possess Toll-like receptors (TLRs) which recognize pathogen-associated molecular patterns (PAMPs) and play a pivotal rol...
G Fava,I Lorenzini
G Fava
Epidemiological data from the last years show an increasing trend of incidence and mortality of cholangiocarcinoma (CC) worldwide. Many pathophysiologic aspects of this neoplasia are still unknown and need to be fully discovered. However, s...