J M Ramia,R De la Plaza,J Quiñones et al.
J M Ramia et al.
Angiomyolipoma of the liver (AML) is an infrequent neoplasm composed of three tissues (adipose, muscle and vessels). In spite of advances in radiology, preoperative correct diagnosis is difficult. Clasically, a conservative management strat...
Alcohol Activates TGF-Beta but Inhibits BMP Receptor-Mediated Smad Signaling and Smad4 Binding to Hepcidin Promoter in the Liver [0.03%]
酒精激活TGF-β但抑制BMP受体介导的Smads信号传导和Smad4与肝脏肝肽启动子的结合
Lisa Nicole Gerjevic,Na Liu,Sizhao Lu et al.
Lisa Nicole Gerjevic et al.
Hepcidin, a key regulator of iron metabolism, is activated by bone morphogenetic proteins (BMPs). Mice pair-fed with regular and ethanol-containing L. De Carli diets were employed to study the effect of alcohol on BMP signaling and hepcidin...
Madhava Pai,Duncan Spalding,Feng Xi et al.
Madhava Pai et al.
Chronic liver disease (CLD) is increasing worldwide yet there has been no major advance in effective therapies for almost five decades. There is mounting evidence that adult haematopoietic stem cells (HSC) are capable of differentiating int...
A Primer on Detecting Cirrhosis and Caring for These Patients without Causing Harm [0.03%]
门脉高压相关疾病的无创诊断及分型中国专家共识及相关问题解读
Bruce Allen Runyon
Bruce Allen Runyon
Many people who have cirrhosis are undiagnosed. The diagnosis may not become evident until they develop multiorgan failure after an invasive procedure. Patients with cirrhosis are unusually fragile and can be easily harmed and even set into...
Multimodal liver-directed management of neuroendocrine hepatic metastases [0.03%]
多模式肝导向神经内分泌肝转移瘤的治疗
Mark A Lewis,Joleen Hubbard
Mark A Lewis
A preponderance of patients with neuroendocrine tumors (NETs) will experience hepatic metastases during the course of their disease. Many diagnoses of NETs are made only after the neoplasms have spread from their primary gastroenteropancrea...
CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases [0.03%]
通过增强氧化应激和细胞毒性介质诱导的CYP2E1活化使肝脏对LPS和TNFα诱导的毒性敏感化
Arthur I Cederbaum,Lili Yang,Xiaodong Wang et al.
Arthur I Cederbaum et al.
The mechanisms by which alcohol causes cell injury are not clear. A major mechanism is the role of lipid peroxidation and oxidative stress in alcohol toxicity. Many pathways have been suggested to play a role in how alcohol induces oxidativ...
Hock-Foong Lui
Hock-Foong Lui
Hepatocellular carcinoma is one of the most serious complications of chronic liver disease and is the third most lethal cancer worldwide. Symptoms emerge very late in the course of its natural history with an attendant poor outcome. Screeni...
Treatment of liver metastases in patients with neuroendocrine tumors: a comprehensive review [0.03%]
神经内分泌肿瘤肝转移的治疗：综述
Theresa R Harring,N Thao N Nguyen,John A Goss et al.
Theresa R Harring et al.
Patients diagnosed with Neuroendocrine Tumors (NET) often are also diagnosed with Neuroendocrine Liver Metastases (NLM) during the course of their disease. NLM can cause significant morbidity and mortality, oftentimes much more than compare...
NCX 1000 Alone or in Combination with Vitamin E Reverses Experimental Nonalcoholic Steatohepatitis in the Rat Similarly to UDCA [0.03%]
NCX 1000单独或与维生素E联用可类似UDCA逆转大鼠实验性非酒精性脂肪肝病
Yara Haddad,Diane Vallerand,Antoine Brault et al.
Yara Haddad et al.
We explored the therapeutic effect of NCX 1000, a derivative of ursodeoxycholic acid (UDCA) with nitric oxide (NO) donating properties, alone or in combination with vitamin E, in an experimental model of NASH in the rat. Methods. A control ...
Aberrant hepatic methionine metabolism and gene methylation in the pathogenesis and treatment of alcoholic steatohepatitis [0.03%]
酒精性脂肪肝炎发病及治疗中肝脏蛋氨酸代谢异常和基因甲基化作用的研究
Charles H Halsted,Valentina Medici
Charles H Halsted
The pathogenesis of alcoholic steatohepatitis (ASH) involves ethanol-induced aberrations in hepatic methionine metabolism that decrease levels of S-adenosylmethionine (SAM), a compound which regulates the synthesis of the antioxidant glutat...