Prophylactic and Therapeutic Breast Conservation in BRCA1/2 Mutation Carriers [0.03%]
BRCA1/2基因突变携带者的预防性和治疗性保乳手术
Randal L Croshaw,Megan L Marshall,Tesha L Williams et al.
Randal L Croshaw et al.
Breast-conserving therapy (BCT) for sporadic breast cancer has been widely accepted by surgeons and patients alike. While BCT is associated with a higher risk of ipsilateral breast tumor recurrence (IBTR), it has not been shown to decrease ...
Hua Wang,Awinder P Singh,Serena A St Luce et al.
Hua Wang et al.
Background. Elderly women with breast cancer are considered underdiagnosed and undertreated, and this adversely affects their overall survival. Methods. A total of 393 female breast cancer patients aged 70 years and older, diagnosed within ...
William C Dooley,Mo Keshtgar,Tibor Tot et al.
William C Dooley et al.
Stromal Expression of CD10 in Invasive Breast Carcinoma and Its Correlation with ER, PR, HER2-neu, and Ki67 [0.03%]
乳腺癌间质CD10表达及其与ER、PR、HER2-neu和Ki67的相关性研究
Vandana Puri,Manjula Jain,Shaji Thomas
Vandana Puri
CD10 is a cell surface zinc-dependent endopeptidase, which degrades many bioactive peptides. CD10 expression in tumour stroma is associated with biological aggressiveness of many epithelial malignancies. To date, only one study has correlat...
CXCR4 and axillary lymph nodes: review of a potential biomarker for breast cancer metastasis [0.03%]
CXCR4和腋窝淋巴结：乳腺癌转移的潜在生物标志物综述
David Hiller,Quyen D Chu
David Hiller
CXCR4 is a 7-transmembrane G-protein chemokine receptor that allows for migration of hematopoietic cells from the bone marrow to the peripheral lymph nodes. Research has shown CXCR4 to be implicated in the invasion and metastasis of several...
W Eljabu,G Finch,J Nottingham et al.
W Eljabu et al.
Breast cancer is the most frequent malignancy in women accounting for approximately 32% of all cancers, with a lifetime risk of 1 in 10. It causes considerable morbidity and mortality. Recently, the survival rate has dramatically increased ...
Intraoperative radiotherapy in the treatment of breast cancer: a review of the evidence [0.03%]
乳腺癌治疗中的术中放疗：证据综述
Norman R Williams,Katharine H Pigott,Mohammed R S Keshtgar
Norman R Williams
The surgical treatment of early breast cancer has evolved from the removal of the entire breast and surrounding tissues (mastectomy) to the removal of the tumour together with a margin of healthy tissue (lumpectomy). Adjuvant radiotherapy, ...
Molecular Mechanisms of Trastuzumab Resistance in HER2 Overexpressing Breast Cancer [0.03%]
HER2扩增型乳腺癌耐曲妥珠单抗的分子机制研究
Gabriel L Fiszman,María A Jasnis
Gabriel L Fiszman
The epidermal growth factor receptor 2 (HER2) is a tyrosine kinase overexpressed in nearly 20% to 25% of invasive breast cancers. Trastuzumab is a humanized monoclonal antibody that targets HER2. The majority of patients with metastatic bre...
Multiple Patterns of FHIT Gene Homozygous Deletion in Egyptian Breast Cancer Patients [0.03%]
埃及乳腺癌患者FHIT基因的多种 homozygous deletion 模式
Heba M S Ismail,Amina M Medhat,Amr M Karim et al.
Heba M S Ismail et al.
Fragile histidine triad (FHIT) gene encodes a putative tumour suppressor protein. Loss of Fhit protein in cancer is attributed to different genetic alterations that affect the FHIT gene structure. In this study, we investigated the pattern ...
Optimization of Adjuvant Radiation in Breast Conservation Therapy: Can We Minimize without Compromise? [0.03%]
保乳手术后辅助放疗的优化：能否在不妥协的情况下减少放疗剂量？
Sophia M Edwards-Bennett,Candace R Correa,Eleanor E Harris
Sophia M Edwards-Bennett
Adjuvant breast radiation therapy after breast conservation surgery is recommended as it yields significant reduction in the risk of local recurrence, and confers a potential overall survival benefit. Although the standard breast radiation ...