Current operative management of breast cancer: an age of smaller resections and bigger cures [0.03%]
当前乳腺癌的外科治疗：小手术大治愈的时代来临
Jack W Rostas,Donna Lynn Dyess
Jack W Rostas
Surgical resection was the first effective treatment for breast cancer and remains the most important treatment modality for curative intent. Refinements in operative techniques along with the use of adjuvant radiotherapy and advanced chemo...
Improving outcomes from breast cancer in a low-income country: lessons from bangladesh [0.03%]
低收入国家乳腺癌治疗经验：来自孟加拉国的启示
H L Story,R R Love,R Salim et al.
H L Story et al.
Women in low- and middle-income countries (LMICs) have yet to benefit from recent advances in breast cancer diagnosis and treatment now experienced in high-income countries. Their unique sociocultural and health system circumstances warrant...
The hedgehog pathway conditions the bone microenvironment for osteolytic metastasis of breast cancer [0.03%]
刺猬信号通路调控骨微环境以促进乳腺癌的溶骨性转移
Shamik Das,Rajeev S Samant,Lalita A Shevde
Shamik Das
The microenvironment at the site of tumor metastasis plays a key role in determining the fate of the metastasizing tumor cells. This ultimately has a direct impact on the progression of cancer. Bone is the preferred site of metastasis of br...
Silvia C Formenti,Alan A Arslan,Susan M Love
Silvia C Formenti
Breast cancer is the most common cancer affecting women globally. This paper discusses the current progress in breast cancer in Western countries and focuses on important differences of this disease in low- and middle-income countries (LMCs...
Molecular basis of triple negative breast cancer and implications for therapy [0.03%]
三阴性乳腺癌的分子基础及其治疗意义
Parvin F Peddi,Matthew J Ellis,Cynthia Ma
Parvin F Peddi
Triple negative breast cancer is an aggressive form of breast cancer with limited treatment options and is without proven targeted therapy. Understanding the molecular basis of triple negative breast cancer is crucial for effective new drug...
The Role of Cancer Stem Cells in the Organ Tropism of Breast Cancer Metastasis: A Mechanistic Balance between the "Seed" and the "Soil"? [0.03%]
癌干细胞在乳腺癌转移器官特异性中的作用：“种子”与“土壤”的平衡？
Jenny E Chu,Alison L Allan
Jenny E Chu
Breast cancer is a prevalent disease worldwide, and the majority of deaths occur due to metastatic disease. Clinical studies have identified a specific pattern for the metastatic spread of breast cancer, termed organ tropism; where preferen...
Should a sentinel node biopsy be performed in patients with high-risk breast cancer? [0.03%]
高危乳腺癌患者需要做哨点淋巴结活检吗？
Kenneth D Westover,M Brandon Westover,Eric P Winer et al.
Kenneth D Westover et al.
A negative sentinel lymph node (SLN) biopsy spares many breast cancer patients the complications associated with lymph node irradiation or additional surgery. However, patients at high risk for nodal involvement based on clinical characteri...
The role of aryl hydrocarbon receptor and crosstalk with estrogen receptor in response of breast cancer cells to the novel antitumor agents benzothiazoles and aminoflavone [0.03%]
芳烃受体在乳腺癌细胞中的作用及其与雌激素受体相互作用对新型抗肿瘤剂苯并噻唑和氨基黄酮的反应中的作用
Mariana A Callero,Andrea I Loaiza-Pérez
Mariana A Callero
Many estrogen-receptor- (ER-) expressing breast cancers become refractory to ER-based therapies. New antitumor drugs like aminoflavone (AF) and benzothiazoles (Bzs) have been developed and have exquisite antitumor activity in ER+MCF-7 and T...
The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer [0.03%]
干扰素调节因子-1(IRF1)在克服抗雌激素耐药治疗乳腺癌中的作用
J L Schwartz,A N Shajahan,R Clarke
J L Schwartz
Resistance to endocrine therapy is common among breast cancer patients with estrogen receptor alpha-positive (ER+) tumors and limits the success of this therapeutic strategy. While the mechanisms that regulate endocrine responsiveness and c...
Patterns of cellular distribution with the sentinel node positive for breast cancer [0.03%]
乳腺癌哨兵淋巴结阳性时的细胞分布规律
Ekaterini Tsiapali,Marcia M Schmidt,Don Dizon et al.
Ekaterini Tsiapali et al.
Background. Sentinel node biopsy (SNB) represents the standard of care in breast cancer axillary evaluation. Our study aims to characterize the patterns of malignant cell distribution within the sentinel nodes (SN). Methods. In a retrospect...