Androgen Metabolism Gene Polymorphisms, Associations with Prostate Cancer Risk and Pathological Characteristics: A Comparative Analysis between South African and Senegalese Men [0.03%]
雄激素代谢基因多态性与前列腺癌风险及病理特征的相关性：南非和塞内加尔男性的比较分析
Pedro Fernandez,Charnita M Zeigler-Johnson,Elaine Spangler et al.
Pedro Fernandez et al.
Prostate cancer is the most common cancer in men in developed countries and the leading cause of mortality in males in less developed countries. African ethnicity is one of the major risk factors for developing prostate cancer. Pathways inv...
Current challenges in development of differentially expressed and prognostic prostate cancer biomarkers [0.03%]
前列腺癌差异表达和预后生物标志物研究现状及挑战
Steven M Lucas,Elisabeth I Heath
Steven M Lucas
Introduction. Predicting the aggressiveness of prostate cancer at biopsy is invaluable in making treatment decisions. In this paper we review the differential expression of genes and microRNAs identified through microarray analysis as poten...
Hypofractionated Prostate Radiotherapy with or without Conventionally Fractionated Nodal Irradiation: Clinical Toxicity Observations and Retrospective Daily Dosimetry [0.03%]
超分割前列腺放射治疗联合或不联合常规分割的淋巴结照射：临床毒性观察及回顾性每日剂量学研究
Andrew M McDonald,Justin M Bishop,Rojymon Jacob et al.
Andrew M McDonald et al.
Purpose. To evaluate toxicity associated with the addition of elective nodal irradiation (ENI) to a hypofractionated regimen for the treatment of prostate cancer. Methods and Materials. Fifty-seven patients received pelvic image-guided IMRT...
Emerging putative biomarkers: the role of alpha 2 and 6 integrins in susceptibility, treatment, and prognosis [0.03%]
新兴生物标志物：α2和α6整合素在易感性、治疗和预后中的作用
James R Marthick,Joanne L Dickinson
James R Marthick
The genetic architecture underpinning prostate cancer is complex, polygenic and despite recent significant advances many questions remain. Advances in genetic technologies have greatly improved our ability to identify genetic variants assoc...
Hypofractionated proton boost combined with external beam radiotherapy for treatment of localized prostate cancer [0.03%]
局部前列腺癌治疗的低分割质子刀根治 boost 结合外照射放疗
Silvia Johansson,Lennart Aström,Fredrik Sandin et al.
Silvia Johansson et al.
Proton boost of 20 Gy in daily 5 Gy fractions followed by external beam radiotherapy (EBRT) of 50 Gy in daily 2 Gy fractions were given to 278 patients with prostate cancer with T1b to T4N0M0 disease. Fifty-three percent of the patients rec...
Dose-escalated hypofractionated intensity-modulated radiotherapy in high-risk carcinoma of the prostate: outcome and late toxicity [0.03%]
前列腺高危癌患者的剂量爬坡式分次强度调控放射治疗的疗效及后遗症状况研究报告
David Thomson,Sophie Merrick,Ric Swindell et al.
David Thomson et al.
Background. The benefit of dose-escalated hypofractionated radiotherapy using intensity-modulated radiotherapy (IMRT) in prostate cancer is not established. We report 5-year outcome and long-term toxicity data within a phase II clinical tri...
Incidentally found prostate cancer and influence on overall survival after radical cystoprostatectomy [0.03%]
偶然发现的前列腺癌及其根治性膀胱前列腺切除术后的生存影响
Algimantas Sruogis,Albertas Ulys,Giedre Smailyte et al.
Algimantas Sruogis et al.
Objectives. To determine incidentally found prostate cancer frequency and impact on overall survival after RCP. Patients and Methods. The records of 81 men who underwent cystoprostatectomy from January 2000 to December 2009 were reviewed. T...
Expression of neutral endopeptidase, endothelin-1, and nuclear factor kappa B in prostate cancer: interrelations and associations with prostate-specific antigen recurrence after radical prostatectomy [0.03%]
前列腺癌中神经肽酶、内皮素-1和核因子κB的表达及其与根治术后 PSA 复发的关系研究
Panagiotis J Vlachostergios,Foteini Karasavvidou,Grigorios Kakkas et al.
Panagiotis J Vlachostergios et al.
Objective. To study the impact of the neutral endopeptidase (NEP)/neuropeptides (NPs) axis and nuclear factor kappa B (NFκB) as predictors of prostate-specific antigen (PSA) recurrence after radical prostatectomy (RP). Patients and Methods...
Markers of field cancerization: proposed clinical applications in prostate biopsies [0.03%]
场癌化的标志物：在前列腺活检中的临床应用建议
Kristina A Trujillo,Anna C Jones,Jeffrey K Griffith et al.
Kristina A Trujillo et al.
Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histologically normal tissues adjacent to cancerous lesions. This paper tabulates markers of prostate field cance...
The current role of androgen deprivation in patients undergoing dose-escalated external beam radiation therapy for clinically localized prostate cancer [0.03%]
雄激素剥夺在剂量 escalation 外照射治疗局部前列腺癌患者中的作用
Michael J Smith,Naveed H Akhtar,Scott T Tagawa
Michael J Smith
Purpose. To review existing literature on the role of androgen deprivation therapy (ADT) with dose escalated radiation therapy. Methods and Materials. A PubMed search was undertaken to identify relevant articles. Results. Multiple recent st...