Low-dose, ionizing radiation and age-related changes in skeletal microarchitecture [0.03%]
低剂量电离辐射与骨骼微结构的年龄相关变化的关系研究
Joshua S Alwood,Akhilesh Kumar,Luan H Tran et al.
Joshua S Alwood et al.
Osteoporosis can profoundly affect the aged as a consequence of progressive bone loss; high-dose ionizing radiation can cause similar changes, although less is known about lower doses (≤100 cGy). We hypothesized that exposure to relatively...
Molecular mechanisms for age-associated mitochondrial deficiency in skeletal muscle [0.03%]
与年龄相关的骨骼肌线粒体功能减退的分子机制
Akira Wagatsuma,Kunihiro Sakuma
Akira Wagatsuma
The abundance, morphology, and functional properties of mitochondria decay in skeletal muscle during the process of ageing. Although the precise mechanisms remain to be elucidated, these mechanisms include decreased mitochondrial DNA (mtDNA...
Sarcopenia: a major challenge in elderly patients with end-stage renal disease [0.03%]
肌减少症是终末期肾病老年患者面临的主要挑战
Maciej Domański,Kazimierz Ciechanowski
Maciej Domański
Sarcopenia is a condition of multifaceted etiology arising in many elderly people. In patients with chronic kidney, the loss of muscle mass is much more intensive and the first signs of sarcopenia are observed in younger patients than it is...
Could questions on activities of daily living estimate grip strength of older adults living independently in the community? [0.03%]
社区老年人日常生活活动的问题能否估计其握力？
Jessica Simard,Maude Chalifoux,Véronique Fortin et al.
Jessica Simard et al.
The aim of this study was to identify questions that could estimate grip strength. Twenty-six questions about the degree of perceived difficulty performing manual tasks as well as two questions concerning self-rated grip strength were devel...
Carlos Spuch,Saida Ortolano,Carmen Navarro
Carlos Spuch
Biochemical and morphological alterations of mitochondria may play an important role in the pathogenesis of Alzheimer's disease (AD). Particularly, mitochondrial dysfunction is a hallmark of amyloid-beta-induced neuronal toxicity in Alzheim...
Aurel Popa-Wagner,Ana-Maria Buga,Ryan C Turner et al.
Aurel Popa-Wagner et al.
Corinna N Ross,Kenneth Davis,Georgina Dobek et al.
Corinna N Ross et al.
Characterizing the phenotypic changes associated with aging in a short-lived primate is necessary in order to develop better translational models for human health, aging, and disease research. A population of conventionally housed marmoset ...
Nutrition and sarcopenia: a review of the evidence and implications for preventive strategies [0.03%]
营养与肌少症：证据回顾及预防策略的启示
Siân Robinson,Cyrus Cooper,Avan Aihie Sayer
Siân Robinson
Prevention of age-related losses in muscle mass and strength is key to protecting physical capability in older age and enabling independent living. To develop preventive strategies, a better understanding is needed of the lifestyle factors ...
Geoffrey Goldspink
Geoffrey Goldspink
Age-related muscle wasting and increased frailty are major socioeconomic as well as medical problems. In the quest to extend quality of life it is important to increase the strength of elderly people sufficiently so they can carry out every...
Intramuscular adipose tissue, sarcopenia, and mobility function in older individuals [0.03%]
老年人群中的肌内脂肪、肌少症和步行能力
Robin L Marcus,Odessa Addison,Leland E Dibble et al.
Robin L Marcus et al.
Objective. Intramuscular adipose tissue (IMAT) and sarcopenia may adversely impact mobility function and physical activity. This study determined the association of locomotor muscle structure and function with mobility function in older adu...