Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? [0.03%]
线粒体储备呼吸能力与衰老有关吗？
Claus Desler,Thomas Lau Hansen,Jane Bruun Frederiksen et al.
Claus Desler et al.
Oxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy. If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue. The term reserv...
Extension of Chronological Lifespan by Hexokinase Mutation in Kluyveromyces lactis Involves Increased Level of the Mitochondrial Chaperonin Hsp60 [0.03%]
酿酒酵母毕赤氏醭霉中糖 kinase 突变通过增加线粒体伴侣蛋白 Hsp60 的水平延长生物生命周期
Lisa Rizzetto,Elena Zanni,Daniela Uccelletti et al.
Lisa Rizzetto et al.
Oxidative damage, mitochondrial dysfunction, genomic instability, and telomere shortening represent all molecular processes proposed as causal factors in aging. Lifespan can be increased by metabolism through an influence on such processes....
Sedentary Behavior and Physical Function Decline in Older Women: Findings from the Women's Health Initiative [0.03%]
妇女健康倡议研究中的久坐行为与老年女性的机体功能减退之间的关系
Rebecca Seguin,Michael Lamonte,Lesley Tinker et al.
Rebecca Seguin et al.
Sedentary behavior is associated with deleterious health outcomes. This study evaluated the association between sedentary time and physical function among postmenopausal women in the Women's Health Initiative Observational Study. Data for t...
Intermuscular adipose tissue is muscle specific and associated with poor functional performance [0.03%]
肌间脂肪组织具有肌肉特异性并导致运动功能表现较差
Lori J Tuttle,David R Sinacore,Michael J Mueller
Lori J Tuttle
Purpose. People with obesity, diabetes, and peripheral neuropathy have high levels of intermuscular adipose tissue (IMAT) volume which has been inversely related to physical function. We determined if IMAT is muscle specific, if calf IMAT i...
Total joint replacement in the past does not relate to a deteriorated functional level and health status in the oldest old [0.03%]
既往的人工关节置换术与最高龄老人的功能水平和健康状态的恶化无关
Wiebe Chr Verra,Anton J M de Craen,Coen C M M Jaspars et al.
Wiebe Chr Verra et al.
Total hip or knee replacement is effective in improving joint function, quality of life, and pain reduction. The oldest old population with joint replacements (TJR) is underrepresented in current literature. We compared health-related and f...
Measurement of harm outcomes in older adults after hospital discharge: reliability and validity [0.03%]
老年患者出院后的损害结果测量：可靠性和有效性
Alison Douglas,Lori Letts,Kevin Eva et al.
Alison Douglas et al.
Objectives. Defining and validating a measure of safety contributes to further validation of clinical measures. The objective was to define and examine the psychometric properties of the outcome "incidents of harm." Methods. The Incident of...
Blockade of electron transport at the onset of reperfusion decreases cardiac injury in aged hearts by protecting the inner mitochondrial membrane [0.03%]
在再灌注开始时阻断电子传递可保护内线粒体膜，减少老年心脏损伤
Qun Chen,Thomas Ross,Ying Hu et al.
Qun Chen et al.
Myocardial injury is increased in the aged heart following ischemia-reperfusion (ISC-REP) compared to adult hearts. Intervention at REP with ischemic postconditioning decreases injury in the adult heart by attenuating mitochondrial driven c...
Dominique Meynial-Denis,Olivier Guérin,Stéphane Michel Schneider et al.
Dominique Meynial-Denis et al.
Agneta Malmgren Fänge,Frank Oswald,Lindy Clemson
Agneta Malmgren Fänge
Yamni Nigam,John Knight,Sharmila Bhattacharya et al.
Yamni Nigam et al.