Eduard Parellada,Dawn I Velligan,Robin Emsley et al.
Eduard Parellada et al.
Faulty suppression of irrelevant material in patients with thought disorder linked to attenuated frontotemporal activation [0.03%]
思病患者的故障性无关信息抑制与前颞叶激活减弱有关
S M Arcuri,M R Broome,V Giampietro et al.
S M Arcuri et al.
Formal thought disorder is a feature schizophrenia that manifests as disorganized, incoherent speech, and is associated with a poor clinical outcome. The neurocognitive basis of this symptom is unclear but it is thought to involve an impair...
Relationships between Brain Structure and Metabolic Changes in Schizophrenia Patients Treated with Olanzapine: A Voxel-Based Morphometric Study [0.03%]
奥氮平治疗精神分裂症患者脑结构与代谢改变的相关性研究：基于体素的形态学测量研究
Genevieve Letourneau,Lahcen Ait Bentaleb,Benjamin Stip et al.
Genevieve Letourneau et al.
Introduction. Second-generation antipsychotics treatment is associated with weight gain and metabolic disturbances. Although much research has been done on the topic, the precise mechanisms underlying such side effects are still not well un...
White matter abnormalities and animal models examining a putative role of altered white matter in schizophrenia [0.03%]
关于精神分裂症白质异常及动物模型的探讨
Haiyun Xu,Xin-Min Li
Haiyun Xu
Schizophrenia is a severe mental disorder affecting about 1% of the population worldwide. Although the dopamine (DA) hypothesis is still keeping a dominant position in schizophrenia research, new advances have been emerging in recent years,...
First- and third-person perspectives in psychotic disorders and mood disorders with psychotic features [0.03%]
精神障碍和心境障碍伴精神病特征的一人称和三人称视角差异
Lucrezia Islam,Silvio Scarone,Orsola Gambini
Lucrezia Islam
Lack of insight, very frequent in schizophrenia, can be considered a deficit in Theory of Mind (ToM) performances, and is also found in other psychiatric disorders. In this study, we used the first- to third-person shift to examine subjects...
Thomas J Whitford,Marek Kubicki,Martha E Shenton
Thomas J Whitford
A fundamental tenet of the "disconnectivity" theories of schizophrenia is that the disorder is ultimately caused by abnormal communication between spatially disparate brain structures. Given that the white matter fasciculi represent the pri...
Very low-dose risperidone in first-episode psychosis: a safe and effective way to initiate treatment [0.03%]
利培酮低起始剂量治疗首次发作的精神病患者：一种安全有效的起始治疗方法
Patrick D McGorry,John Cocks,Paddy Power et al.
Patrick D McGorry et al.
Patients experiencing a first psychotic episode have high rates of extrapyramidal symptoms (EPSs) when treated with the doses of neuroleptics used in multiepisode or chronic schizophrenia. There is some evidence that lower doses may be equa...
Dissecting the Syndrome of Schizophrenia: Progress toward Clinically Useful Biomarkers [0.03%]
解构精神分裂症综合症：迈向临床实用生物标志物的进展
Brian Dean
Brian Dean
The search for clinically useful biomarkers has been one of the holy grails of schizophrenia research. This paper will outline the evolving notion of biomarkers and then outline outcomes from a variety of biomarkers discovery strategies. In...
Second generation antipsychotics improve sexual dysfunction in schizophrenia: a randomised controlled trial [0.03%]
二代抗精神病药可改善精神分裂症患者的性功能障碍：一项随机对照试验
Ahmed Mahmoud,Karen P Hayhurst,Richard J Drake et al.
Ahmed Mahmoud et al.
The impact of antipsychotic drug treatment on sexual function was investigated during a randomised trial comparing first generation antipsychotics (FGAs) to (nonclozapine) second generation antipsychotics (SGAs). Sexual function and quality...
Murat Yildiz,Stefan J Borgwardt,Gregor E Berger
Murat Yildiz
Objective. Despite observations that abnormal parietal lobe (PL) function is associated with psychotic-like experiences, our knowledge about the nature of PL involvement in schizophrenia is modest. The objective of this paper is to investig...