Peripheral galanin receptor 2 as a target for the modulation of pain [0.03%]
外周神经肽Galanin受体2在痛觉调制中的作用
Richard P Hulse,Lucy F Donaldson,David Wynick
Richard P Hulse
The neuropeptide galanin is widely expressed in the nervous system and has an important role in nociception. It has been shown that galanin can facilitate and inhibit nociception in a dose-dependent manner, principally through the central n...
Glutaminase immunoreactivity and enzyme activity is increased in the rat dorsal root ganglion following peripheral inflammation [0.03%]
外周炎症后脊髓背根神经节中的谷氨酰胺酶免疫反应性和酶活性增加
Kenneth E Miller,John C Balbás,Richard L Benton et al.
Kenneth E Miller et al.
Following inflammation, primary sensory neurons in the dorsal root ganglion (DRG) alter the production of several proteins. Most DRG neurons are glutamatergic, using glutaminase as the enzyme for glutamate production, but little is known ab...
Glutamate Transporter GLT-1 Upregulation Attenuates Visceral Nociception and Hyperalgesia via Spinal Mechanisms Not Related to Anti-Inflammatory or Probiotic Effects [0.03%]
谷氨酸转运蛋白GLT-1上调通过非抗炎或益生菌作用的脊髓机制来减弱内脏疼痛和痛觉过敏
Y Lin,K Roman,K D Foust et al.
Y Lin et al.
Visceral pain is the most common reason for physician visits in US. Glutamate is the major excitatory neurotransmitter and mediates visceral nociceptive neuro-transmission and hypersensitivity. Removal of extracellular glutamate is predomin...
ASICs Do Not Play a Role in Maintaining Hyperalgesia Induced by Repeated Intramuscular Acid Injections [0.03%]
ASICs不参与重复肌肉内注射酸诱导的痛觉过敏的维持作用
Mamta Gautam,Christopher J Benson,Jon D Ranier et al.
Mamta Gautam et al.
Repeated intramuscular acid injections produce long-lasting mechanical hyperalgesia that depends on activation of ASICs. The present study investigated if pH-activated currents in sensory neurons innervating muscle were altered in response ...
Muhammad B Yunus
Muhammad B Yunus
Central sensitivity syndromes (CSS) include fibromyalgia syndrome (FMS), irritable bowel syndrome, temporomandibular disorder, restless legs syndrome, chronic fatigue syndrome, and other similar chronic painful conditions that are based on ...
Fibromyalgia and depression [0.03%]
纤维肌痛和抑郁
Richard H Gracely,Marta Ceko,M Catherine Bushnell
Richard H Gracely
Fibromyalgia and depression might represent two manifestations of affective spectrum disorder. They share similar pathophysiology and are largely targeted by the same drugs with dual action on serotoninergic and noradrenergic systems. Here,...
M Lundberg,A Grimby-Ekman,J Verbunt et al.
M Lundberg et al.
Objectives: In regards to pain-related fear, this study aimed to: (1) identify existing measures and review their measurement properties, and (2) identify the optimum measure for specific constructs of fear-avoidance, pai...
Thelma J Mielenz,Robert F Devellis,Michele C Battie et al.
Thelma J Mielenz et al.
Background. The psychometric properties of the Modified Work APGAR (MWA) scale are not established, yet researchers use this scale as an overall measure of job satisfaction. Objective. Perform psychometric analyses on the MWA scale using da...
Elizabeth Namukwaya,Mhoira Leng,Julia Downing et al.
Elizabeth Namukwaya et al.
Pain in cancer is a common and burdensome symptom with different causes but in a significant number of cases it is undiagnosed and undertreated because of lack of skills for its assessment. Pain has significant negative impact on the patien...
Marta Ceko,M Catherine Bushnell,Richard H Gracely
Marta Ceko
Fibromyalgia is characterized by chronic widespread pain, clinical symptoms that include cognitive and sleep disturbances, and other abnormalities such as increased sensitivity to painful stimuli, increased sensitivity to multiple sensory m...