Interaction between Mu and Delta Opioid Receptor Agonists in an Assay of Capsaicin-Induced Thermal Allodynia in Rhesus Monkeys [0.03%]
用于评估辣椒素诱导热性异常痛的恒河猴实验中μ阿片受体和δ阿片受体激动剂的作用关系研究
S Stevens Negus,Ember M Morrissey,John E Folk et al.
S Stevens Negus et al.
Delta opioid agonists enhance antinociceptive effects of mu-opioid agonists in many preclinical assays of acute nociception, but delta/mu interactions in preclinical models of inflammation-associated pain have not been examined. This study ...
A Quantitative Examination of Extreme Facial Pain Expression in Neonates: The Primal Face of Pain across Time [0.03%]
定量评估新生儿极端面部疼痛表达：时间上的原始痛苦面孔
Martin Schiavenato,Carl L von Baeyer
Martin Schiavenato
Many pain assessment tools for preschool and school-aged children are based on facial expressions of pain. Despite broad use, their metrics are not rooted in the anatomic display of the facial pain expression. We aim to describe quantitativ...
Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury: Comparison of hNT2.17 and hNT2.19 Cell Lines [0.03%]
人神经前体细胞移植治疗外周和中枢神经系统损伤模型所致神经痛的潜能：hNT2.17与hNT2.19细胞系的比较研究
Mary J Eaton,Yerko Berrocal,Stacey Q Wolfe
Mary J Eaton
Effective treatment of sensory neuropathies in peripheral neuropathies and spinal cord injury (SCI) is one of the most difficult problems in modern clinical practice. Cell therapy to release antinociceptive agents near the injured spinal co...
Mellar P Davis
Mellar P Davis
Visceral pain is experienced by 40% of the population, and 28% of cancer patients suffer from pain arising from intra- abdominal metastasis or from treatment. Neuroanatomy of visceral nociception and neurotransmitters, receptors, and ion ch...
Antineuropathic and antinociceptive drugs combination in patients with chronic low back pain: a systematic review [0.03%]
慢性下腰痛患者的抗神经病理性镇痛药和抗伤害性镇痛药联合应用：系统评价研究
Carlo Luca Romanò,Delia Romanò,Marco Lacerenza
Carlo Luca Romanò
Purpose. Chronic low back pain (LBP) is often characterized by both nociceptive and neuropathic components. While various monotherapies have been reported of only limited efficacy, combining drugs with different mechanisms of action and tar...
Efficacy and tolerability of fixed-dose combination of dexketoprofen and dicyclomine injection in acute renal colic [0.03%]
DEXKETOPROFEN和DICLYCOMINE固定剂量复方注射液治疗急性肾绞痛的疗效及耐受性研究
A Porwal,A D Mahajan,D S Oswal et al.
A Porwal et al.
Objective. To evaluate the efficacy and tolerability of a fixed-dose combination of dexketoprofen and dicyclomine (DXD) injection in patients with acute renal colic. Patients and Methods. Two hundred and seventeen patients were randomized t...
Maral Tajerian,Magali Millecamps,Laura S Stone
Maral Tajerian
Chronic low back pain (LBP) is a debilitating condition associated with signs of axial and radiating pain. In humans with chronic LBP, opioids are often prescribed with varying outcomes and a multitude of side effects. Combination therapies...
Low back pain [0.03%]
下背痛
Seiji Ohtori,Yasuchika Aoki,Gen Inoue et al.
Seiji Ohtori et al.
Aldric Hama,Jacqueline Sagen
Aldric Hama
A number of mechanisms have been elucidated that maintain neuropathic pain due to spinal cord injury (SCI). While target-based therapeutics are being developed based on elucidation of these mechanisms, treatment for neuropathic SCI pain has...
Annette O Arthur,Peyton Holder
Annette O Arthur
Patients with severe, painful injuries and illnesses treated in the emergency department are commonly administered opioid medications. Intravenous administration provides the most rapid onset of pain relief and is readily titrated. Fentanyl...