Matrix metalloproteinases in neuropathic pain and migraine: friends, enemies, and therapeutic targets [0.03%]
神经病理性疼痛和偏头痛中的基质金属蛋白酶：伙伴、对手及治疗靶点
Shaheen E Lakhan,Mihaela Avramut
Shaheen E Lakhan
Matrix metalloproteinases (MMPs) constitute a family of zinc-dependent endopeptidases that mediate extracellular matrix turnover and associated processes, such as cell survival, growth, and differentiation. This paper discusses important fu...
Parents' initial perceptions of multidisciplinary care for pediatric chronic pain [0.03%]
家长对儿科慢性疼痛多学科护理的初始看法
Ayala Y Gorodzinsky,Susan T Tran,Gustavo R Medrano et al.
Ayala Y Gorodzinsky et al.
Chronic and recurrent pain is experienced by many children and adolescents. Treatment of chronic pain using a multidisciplinary approach has been found to be effective for treatment of chronic pain. Parent satisfaction with treatment and tr...
Lumbar facet joint compressive injury induces lasting changes in local structure, nociceptive scores, and inflammatory mediators in a novel rat model [0.03%]
一种新的大鼠模型中腰椎关节突压缩性损伤可诱导局部结构、痛觉过敏评分及炎症介质的持久变化
James L Henry,Kiran Yashpal,Howard Vernon et al.
James L Henry et al.
Objective. To develop a novel animal model of persisting lumbar facet joint pain. Methods. Sprague Dawley rats were anaesthetized and the right lumbar (L5/L6) facet joint was exposed and compressed to ~1 mm with modified clamps applied for ...
Validation of the Self-Assessment of Treatment Questionnaire among Patients with Postherpetic Neuralgia [0.03%]
带状疱疹后神经痛患者自我疗效评估量表的验证研究
Kathleen W Wyrwich,Ariane K Kawata,Christine Thompson et al.
Kathleen W Wyrwich et al.
Introduction. A five-item Self-Assessment of Treatment (SAT) was developed to assess improvement and satisfaction with treatment associated with the application of a novel high concentration 8% capsaicin topical patch in clinical trials in ...
A new drug release method in early development of transdermal drug delivery systems [0.03%]
经皮给药系统早期研发中的新药物释放方法
Bing Cai,Karin Söderkvist,Håkan Engqvist et al.
Bing Cai et al.
In vitro drug release tests are a widely used tool to measure the variance between transdermal product performances and required by many authorities. However, the result cannot provide a good estimation of the in vivo drug release. In the p...
Mario I Ortiz,María Asunción Romero Molina,Young-Chang P Arai et al.
Mario I Ortiz et al.
Review of the history and current status of cell-transplant approaches for the management of neuropathic pain [0.03%]
细胞移植治疗神经病理性疼痛的研究进展与现状分析
Mary J Eaton,Yerko Berrocal,Stacey Q Wolfe et al.
Mary J Eaton et al.
Treatment of sensory neuropathies, whether inherited or caused by trauma, the progress of diabetes, or other disease states, are among the most difficult problems in modern clinical practice. Cell therapy to release antinociceptive agents n...
Temporal summation of pain is not amplified in a large proportion of fibromyalgia patients [0.03%]
纤维肌痛患者中相当一部分人的疼痛时间总和不会被放大
Stéphane Potvin,Emilie Paul-Savoie,Mélanie Morin et al.
Stéphane Potvin et al.
Background. Recently, it has been proposed that fibromyalgia (FM), a chronic widespread pain syndrome, results from overactive endogenous excitatory pain mechanisms. Experimental studies using temporal summation paradigms have confirmed thi...
Julie Harker,Kim J Reid,Geertruida E Bekkering et al.
Julie Harker et al.
Introduction. Estimates on the epidemiology of chronic pain vary widely throughout Europe. It is unclear whether this variation reflects true differences between populations or methodological factors. Information on the epidemiology of chro...
Attitudinal Barriers to Analgesic Use among Patients with Substance Use Disorders [0.03%]
物质使用障碍患者使用镇痛药的态度障碍
Leah Zallman,Sonia L Rubens,Richard Saitz et al.
Leah Zallman et al.
Attitudinal barriers towards analgesic use among primary care patients with chronic pain and substance use disorders (SUDs) are not well understood. We evaluated the prevalence of moderate to significant attitudinal barriers to analgesic us...