The PCR-Based Diagnosis of Central Nervous System Tuberculosis: Up to Date [0.03%]
中枢神经系统结核的PCR诊断：最新进展
Teruyuki Takahashi,Masato Tamura,Toshiaki Takasu
Teruyuki Takahashi
Central nervous system (CNS) tuberculosis, particularly tuberculous meningitis (TBM), is the severest form of Mycobacterium tuberculosis (M.Tb) infection, causing death or severe neurological defects in more than half of those affected, in ...
An IMS/ATP Assay for the Detection of Mycobacterium tuberculosis in Urine [0.03%]
用于检测尿液中结核分枝杆菌的IMS/ATP测定法
Dawn M Hunter,Daniel V Lim
Dawn M Hunter
Background. Although sputum smears are the gold standard for diagnosis of tuberculosis, sensitivity in HIV/TB coinfection cases is low, indicating a need for alternative methods. Urine is being increasingly evaluated. Materials and Methods....
Antimycobacterial Activities of Novel 5-(1H-1,2,3-Triazolyl)Methyl Oxazolidinones [0.03%]
新型5-(1h-1,2,3-三唑甲基)恶唑烷酮的抗分枝杆菌活性
Oludotun Adebayo Phillips,Edet Ekpenyong Udo,Reny Varghese
Oludotun Adebayo Phillips
The antibacterial activities of a series of triazolyl oxazolidinones against Mycobacterium tuberculosis strain in vitro and in vivo in a mice model are presented. Most active compounds were noncytotoxic against VERO cells with acceptable se...
The use of interferon gamma release assays in the diagnosis of active tuberculosis [0.03%]
干扰素伽马释放试验在活动性结核病诊断中的应用
Silvan M Vesenbeckh,Nicolas Schönfeld,Harald Mauch et al.
Silvan M Vesenbeckh et al.
Interferon gamma release assays (IGRAs) are in vitro immunologic diagnostic tests used to identify Mycobacterium tuberculosis infection. They cannot differentiate between latent and active infections. The cutoff suggested by the manufacture...
Maintenance of Sensitivity of the T-SPOT.TB Assay after Overnight Storage of Blood Samples, Dar es Salaam, Tanzania [0.03%]
坦桑尼亚达累斯萨拉姆地区全血保存对T-SPOT.TB检测灵敏度的影响研究
Elizabeth A Talbot,Isaac Maro,Katherine Ferguson et al.
Elizabeth A Talbot et al.
Background. T-SPOT.TB is an interferon gamma release assay for detecting Mycobacterium tuberculosis infection. The requirement to process within 8 hours is constraining, deters use, and leads to invalid results. Addition of T Cell Xtend rea...
Comparison of overnight pooled and standard sputum collection method for patients with suspected pulmonary tuberculosis in northern Tanzania [0.03%]
坦桑尼亚北部疑似肺结核患者一次性合并集痰法与标准集痰法对比研究
Stellah G Mpagama,Charles Mtabho,Solomon Mwaigwisya et al.
Stellah G Mpagama et al.
In Tanzania sputum culture for tuberculosis (TB) is resource intensive and available only at zonal facilities. In this study overnight pooled sputum collection technique was compared with standard spot morning collection among pulmonary TB ...
Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis [0.03%]
一类 oxadiazoline 和 lignan 类化合物通过作用于结核分枝杆菌细胞壁生物合成并引起细菌超微结构变化发挥抗菌活性
Eduard Baquero,Wiston Quiñones,Wellman Ribon et al.
Eduard Baquero et al.
Tuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycoba...
Stratified Threshold Values of QuantiFERON Assay for Diagnosing Tuberculosis Infection in Immunocompromised Populations [0.03%]
免疫功能低下人群结核感染诊断用分层定量阈值法评估结果
Haruyuki Ariga,Hideaki Nagai,Atsuyuki Kurashima et al.
Haruyuki Ariga et al.
Background. The detection of latent tuberculosis (TB) is essential for TB control, but T-cell assay might be influenced by degree of immunosuppression. The relationship between immunocompetence and interferon (IFN)-γ response in QuantiFERO...
Lactoferrin Augmentation of the BCG Vaccine Leads to Increased Pulmonary Integrity [0.03%]
乳铁蛋白增强BCG疫苗可提高肺部完整性
Shen-An Hwang,Kerry J Welsh,Marian L Kruzel et al.
Shen-An Hwang et al.
The goal of vaccination to prevent tuberculosis disease (TB) is to offer long-term protection to the individual and the community. In addition, the success of any protective TB vaccine should include the ability to limit cavitary formation ...
Grace E Marx,Edward D Chan
Grace E Marx
Tuberculous meningitis (TBM) is the most common form of central nervous system tuberculosis (TB) and has very high morbidity and mortality. TBM is typically a subacute disease with symptoms that may persist for weeks before diagnosis. Chara...