Randomized controlled trial of the effectiveness of genetic counseling and a distance, computer-based, lifestyle intervention program for adult offspring of patients with type 2 diabetes: background, study protocol, and baseline patient characteristics [0.03%]
糖尿病2型基因咨询和远程计算机行为干预的随机对照试验（研究背景、实验设计及受试者基线特征）
M Nishigaki,Y Tokunaga-Nakawatase,J Nishida et al.
M Nishigaki et al.
Relatives of type 2 diabetic patients are at a high risk of developing type 2 diabetes and should be regarded as target of intervention for diabetes prevention. However, it is usually hard to motivate them to implement preventive lifestyle ...
Culture Positivity of CVCs Used for TPN: Investigation of an Association with Catheter-Related Infection and Comparison of Causative Organisms between ICU and Non-ICU CVCs [0.03%]
用于TPN的CVCs的文化阳性：与导管相关感染的关系调查以及ICU和非ICU CVCs病原体的比较
Criona Walshe,J Bourke,M Lynch et al.
Criona Walshe et al.
A relationship between central venous catheter (CVC) tip colonisation and catheter-related blood-stream infection (CRBSI) has been suggested. We examined culture positivity of CVC tips (colonised and infected CVCs) in a total parenteral nut...
Functional foods and nutraceuticals in the primary prevention of cardiovascular diseases [0.03%]
功能性食品及保健食品在心血管疾病初级预防中的作用
Eman M Alissa,Gordon A Ferns
Eman M Alissa
Cardiovascular disease (CVD) is now the leading cause of death globally and is a growing health concern. Dietary factors are important in the pathogenesis of CVD and may to a large degree determine CVD risk, but have been less extensively i...
E Patterson,R Wall,G F Fitzgerald et al.
E Patterson et al.
Omega-6 (n-6) polyunsaturated fatty acids (PUFA) (e.g., arachidonic acid (AA)) and omega-3 (n-3) PUFA (e.g., eicosapentaenoic acid (EPA)) are precursors to potent lipid mediator signalling molecules, termed "eicosanoids," which have importa...
Neonatal SSRI Exposure Programs a Hypermetabolic State in Adult Mice [0.03%]
新生儿接触SSRI会诱发成年小鼠新陈代谢亢进状态
Gary J Kummet,Sarah E Haskell,Gregory M Hermann et al.
Gary J Kummet et al.
Background. Selective serotonin reuptake inhibitor (SSRI) therapy complicates up to 10% of pregnancies. During therapy, SSRIs exert pleiotropic antidepressant, anorexigenic, and neurotrophic effects. Intrauterine SSRI exposure has been mode...
Maternal Hyperglycemia Disrupts Histone 3 Lysine 36 Trimethylation of the IGF-1 Gene [0.03%]
母体高血糖可扰乱胰岛素样生长因子IGF-1基因组第36位赖氨酸三甲基化状态的组蛋白H3修饰
Erin K Zinkhan,Qi Fu,Yan Wang et al.
Erin K Zinkhan et al.
In utero environmental adaptation may predispose to lifelong morbidity. Organisms fine-tune gene expression to achieve environmental adaptation by epigenetic alterations of histone markers of gene accessibility. One example of epigenetics i...
The Effect of Neonatal Leptin Antagonism in Male Rat Offspring Is Dependent upon the Interaction between Prior Maternal Nutritional Status and Post-Weaning Diet [0.03%]
新生幼鼠 leptin 抗体的影响依赖于先前的母营养状况和断奶后的饮食之间的相互作用
J Beltrand,D M Sloboda,K L Connor et al.
J Beltrand et al.
Epidemiological and experimental studies report associations between overweight mothers and increased obesity risk in offspring. It is unclear whether neonatal leptin regulation mediates this association between overweight mothers and offsp...
Fábio S Lira,Luiz C Carnevali Jr,Nelo E Zanchi et al.
Fábio S Lira et al.
Lipid metabolism in the liver is complex and involves the synthesis and secretion of very low density lipoproteins (VLDL), ketone bodies, and high rates of fatty acid oxidation, synthesis, and esterification. Exercise training induces sever...
Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a MaternalLow-ProteinDiet [0.03%]
母鼠低蛋白饮食可降低大鼠肾脏线粒体的呼吸作用
Sarah Engeham,Kennedy Mdaki,Kirsty Jewell et al.
Sarah Engeham et al.
Maternal protein restriction in rat pregnancy is associated with impaired renal development and age-related loss of renal function in the resulting offspring. Pregnant rats were fed either control or low-protein (LP) diets, and kidneys from...
Bernard Venn,Frank Thies,Carol O&#x;Neil
Bernard Venn