Toll-like receptors in leishmania infections: guardians or promoters? [0.03%]
toll-like受体在利什曼病感染中的作用：卫士还是促进者？
Marilia S Faria,Flavia C G Reis,Ana Paula C A Lima
Marilia S Faria
Protozoa of the genus Leishmania cause a wide variety of pathologies ranging from self-healing skin lesions to visceral damage, depending on the parasite species. The outcome of infection depends on the quality of the adaptive immune respon...
Comparison and Optimization of Different Methods for the In Vitro Production of Plasmodium falciparum Gametocytes [0.03%]
体外产生恶性疟原虫配子体的不同方法的比较与优化研究
María Roncalés,Jaume Vidal-Mas,Didier Leroy et al.
María Roncalés et al.
The generation of sexually committed parasites (gametocytogenesis) is poorly understood in malaria. If the mechanisms regulating this process were elucidated, new opportunities for blocking malaria transmission could be revealed. Here we co...
Evidence for T Cell Help in the IgG Response against Tandemly Repetitive Trypanosoma cruzi B13 Protein in Chronic Chagas Disease Patients [0.03%]
慢性查加斯病患者中针对克隆的Tandem重复体T.cruzi B13蛋白IgG应答中的T细胞辅助作用证据
Marcia Duranti,Ludmila Camargo,Gabriel Victora et al.
Marcia Duranti et al.
The tandemly repetitive Trypanosoma cruzi B13 protein is an immunodominant antigen among Chagas disease patients. Such repetitive domains may behave as T-independent antigens. However, T cells can recognize B13 epitopes in an HLA class II-r...
Short Communication: Some Observations on the Role of Bradykinin in Immunity to Teladorsagia circumcincta in Sheep [0.03%]
简报:血清素在黑麦保护小鼠肠道屏障功能中的作用研究
Andrew R Williams
Andrew R Williams
Bradykinin is a physiologically active peptide involved in vasodilation and smooth muscle contraction and is previously shown to be increased in gastrointestinal mucus during nematode challenge in sheep. Here, it is shown that bradykinin in...
Innate immune activation and subversion of Mammalian functions by leishmania lipophosphoglycan [0.03%]
利什曼原虫脂磷酸糖对哺乳动物固有免疫激活及功能破坏作用的研究
Luis H Franco,Stephen M Beverley,Dario S Zamboni
Luis H Franco
Leishmania promastigotes express several prominent glycoconjugates, either secreted or anchored to the parasite surface. Of these lipophosphoglycan (LPG) is the most abundant, and along with other phosphoglycan-bearing molecules, plays impo...
Association between Micronutrients (Vitamin A, D, Iron) and Schistosome-Specific Cytokine Responses in Zimbabweans Exposed to Schistosoma haematobium [0.03%]
维生素A、D和铁与 zugzwangel血吸虫暴露人群特异性细胞因子反应之间的关系
Liam Reilly,Norman Nausch,Nicholas Midzi et al.
Liam Reilly et al.
Micronutrients play an important role in the development of effective immune responses. This study characterised a populations exposed to schistosome infections in terms of the relationship between micronutrients and immune responses. Level...
Subversion of Immunity by Leishmania amazonensis Parasites: Possible Role of Phosphatidylserine as a Main Regulator [0.03%]
利什曼原虫对免疫的反调控作用：磷脂酰丝氨酸可能是主要调节因子
Joao Luiz Mendes Wanderley,Jaqueline França Costa,Valéria Matos Borges et al.
Joao Luiz Mendes Wanderley et al.
Leishmania amazonensis parasites cause progressive disease in most inbred mouse strains and are associated with the development of diffuse cutaneous leishmaniasis in humans. The poor activation of an effective cellular response is correlate...
Thymus atrophy and double-positive escape are common features in infectious diseases [0.03%]
胸腺萎缩和双阳性细胞逃逸是传染病的常见特征
Juliana de Meis,Désio Aurélio Farias-de-Oliveira,Pedro H Nunes Panzenhagen et al.
Juliana de Meis et al.
The thymus is a primary lymphoid organ in which bone marrow-derived T-cell precursors undergo differentiation, leading to migration of positively selected thymocytes to the T-cell-dependent areas of secondary lymphoid organs. This organ can...
New Insights on the Inflammatory Role of Lutzomyia longipalpis Saliva in Leishmaniasis [0.03%]
卢焦氏长刺毛爪沙鼠热病中利士曼原虫毒液的炎症作用的新见解
Deboraci Brito Prates,Théo Araújo-Santos,Cláudia Brodskyn et al.
Deboraci Brito Prates et al.
When an haematophagous sand fly vector insect bites a vertebrate host, it introduces its mouthparts into the skin and lacerates blood vessels, forming a hemorrhagic pool which constitutes an intricate environment of cell interactions. In th...
The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development [0.03%]
致病寄生虫原生动物克鲁兹锥虫的免疫反应： toll样受体的作用及疫苗开发展望
Mauricio M Rodrigues,Ana Carolina Oliveira,Maria Bellio
Mauricio M Rodrigues
In the past ten years, studies have shown the recognition of Trypanosoma cruzi-associated molecular patterns by members of the Toll-like receptor (TLR) family and demonstrated the crucial participation of different TLRs during the experimen...