Clinical Serum-Anchored Computational Design Pipeline for a Broad-Spectrum Influenza Multi-Epitope mRNA Vaccine [0.03%]
一种临床血清锚定的计算设计通量用于广谱流感多抗原mRNA疫苗
Lifang Yuan,Zhiyao Ouyang,Yifan Zhao et al.
Lifang Yuan et al.
Influenza's pandemic threat is driven by antigenic drift, which limits the efficacy of conventional vaccines. To address this challenge, we established a clinical serum-anchored computational design pipeline for a broad-spectrum multi-epito...
Matteo Canale,Fabrizia Suzzi,Alberto Verlicchi et al.
Matteo Canale et al.
Small-cell lung cancer (SCLC) is the most lethal histologic subtype of lung cancer. It is characterized by rapid tumor growth and early metastatic dissemination, resulting in an extremely poor prognosis. The addition of immunotherapy to sta...
Retinol Binding Protein 4 Promotes Chondrocyte and Osteoclast Differentiation [0.03%]
视黄醇结合蛋白4促进软骨细胞及破骨细胞分化
Adam Quincey,Subburaman Mohan,Bouchra Edderkaoui
Adam Quincey
Retinol-binding protein 4 (RBP4), an adipokine secreted by adipose tissues, has been implicated in metabolic inflammation and insulin resistance. Type 2 diabetes (T2D) is a recognized risk factor for osteoarthritis, with both conditions cha...
De Novo Transcriptome Profiling of Salt Stress Responses in the Crop Wild Legume Vicia hirsuta (L.) Gray [0.03%]
一种野生作物毛叶扁豆盐胁迫响应的从头转录组特征分析
Sang Yong Park,Dae Yeon Kim,Myoung-Jun Jang et al.
Sang Yong Park et al.
Salt stress is a major environmental constraint affecting plant growth and productivity. Crop wild relatives provide valuable genetic resources for stress tolerance, yet transcriptomic information for forest-derived wild species remains lim...
Population Structure and Growth Dynamics of the Invasive Blue Crab Callinectes sapidus in the Loukkos Estuary (Morocco) [0.03%]
摩洛哥卢科斯河口入侵蓝蟹Callinectes sapidus的种群结构与增长动力学
Feirouz Touhami,Hocein Bazairi
Feirouz Touhami
This study provides the first insights into the biology of the blue crab Callinectes sapidus in the Loukkos Estuary, based on 461 individuals collected between December 2022 and November 2023. Results indicate a well-structured invasive pop...
Comparative Chloroplast Genome and Phylogenetic Analyses of Anna and Lysionotus (Gesneriaceae) Along the Sino-Vietnamese Border [0.03%]
中越边境风铃花属和安娜梅亚珠属叶绿体基因组比较及亲缘关系分析
Jiahui Li,Zhangping Huang,Weibin Xu et al.
Jiahui Li et al.
Sympatric species share identical geographical spaces, climatic conditions and survival pressures. Comparative chloroplast genomes among Anna and Lysionotus sympatric species enable exploration of genome-wide evolutionary dynamics of sympat...
Patterns of Orchid Diversity and Their Potential Habitat Under Climate Change in Chongqing, China [0.03%]
气候变化下重庆市兰科植物多样性格局及生境分布潜力评估
Huan Zhang,Mingwei Tang,Yiyun Wang et al.
Huan Zhang et al.
Global climate problems and the sharp decline in biodiversity have attracted widespread attention. Orchids, as the "flagship" species of biodiversity, are important indicators of ecological changes. This study took Chongqing as the study ar...
Genome-Wide Association Study of Genetic Variants Associated with Serum Albumin Levels in Chinese Winter Sports Athletes [0.03%]
中国冬季运动员血清白蛋白水平相关基因变异的全基因组关联研究
Tao Mei,Yanchun Li,Dapeng Bao et al.
Tao Mei et al.
This study aimed to explore genetic variants associated with serum albumin (ALB) levels in Chinese winter sports athletes using genome-wide association analysis (GWAS) and to investigate potential regulatory mechanisms using bioinformatics ...
Combined Impacts of Nitrogen Forms, Rice Husk Biochar, and Water Regime on Purple Rice Yield and Grain Quality [0.03%]
氮素形态、稻壳生物炭和水分调控对紫色水稻产量及米质的复合效应
Rachanat Limsomnuek,Supapohn Yamuangmorn,Rotsukon Jawana et al.
Rachanat Limsomnuek et al.
Purple rice contains beneficial bioactive compounds, but the concentrations can be influenced by the growing conditions. This study investigated the interactive effects of water regime, biochar amendment, and nitrogen (N) sources on the yie...
Non-Canonical Maternal WNT4 Activates Canonical Zygotic WNT8C for Early Embryonic Development in Chicken [0.03%]
非经典的母源性WNT4通过激活经典型的合子WNT8C促进鸡早期胚胎发育
Young Sun Hwang,Sang Kyung Kim,Jae Yong Han
Young Sun Hwang
The proper regulation of signaling pathways, including WNT signaling, during early embryonic development is critical for whole-organism development. In particular, maternally enriched WNTs play critical roles in cell cleavage and axis forma...