A Comparative Evaluation of Four Bioinformatic Tools for Identifying HIV-1 pol Drug Resistance Mutations Using Illumina MiSeq Data [0.03%]
四种生物信息工具利用illumina miseq数据识别HIV-1 pol耐药突变的比较研究
Ogestelli Fabia Lee,Chun Kiat Lee
Ogestelli Fabia Lee
The transition from Sanger to next-generation sequencing (NGS) for HIV-1 drug resistance testing offers enhanced sensitivity but also introduces bioinformatic variability. This study evaluated four strategies: the commercial Exatype platfor...
Ultrastructural Evidence for Dual Sperm Morphotypes in Hormone-Induced Japanese Eel (Anguilla japonica): Implications for Sperm Maturation [0.03%]
激素诱导的日本鳗鱼(Anguilla japonica)双精型超微结构证据及其对精子成熟的启示
Xiaorong Huang,Jianyi Liu,Chao Song et al.
Xiaorong Huang et al.
The microstructure and ultrastructure of the sperm of Japanese eel, Anguilla japonica, artificially induced with weekly injections with carp pituitary (CP) and human chorionic gonadotropin (HCG), was studied, and milt from 10 out of 20 matu...
Study on the Role of the AMPK/PGC-1α Pathway in Cold-Induced Vascular Endothelial Cell Apoptosis and Uterine Damage [0.03%]
AMPK/PGC-1α通路在冷应激诱导血管内皮细胞凋亡及子宫损伤中作用机制的研究
Sufen Bai,Xiaojin La,Yiting Yang et al.
Sufen Bai et al.
Cold exposure may influence reproductive health through vascular changes, yet its mechanisms remain underexplored. This study aimed to investigate the impact of cold exposure on uterine blood vessels and the expression of the AMPK/PGC-1α g...
Kukoamine B Inhibits EMT in Lung Adenocarcinoma Cells by Regulating Intracellular PD-L1-Mediated p65 Nuclear Translocation [0.03%]
库可胺B通过调节细胞内PD-L1介导的p65核转位抑制肺腺癌上皮间质转化
Congyan Hou,Jingqin Chen,Lisheng Zhang et al.
Congyan Hou et al.
Cortex Lycii Radicis, a medicinal plant, has been reported to inhibit epithelial-mesenchymal transition (EMT) and exhibit anti-lung cancer properties. Our previous study identified its major compound, Kukoamine B (KuB), as an inhibitor of m...
Transcriptomic and Microbiome Analyses of Procambarus clarkii Exposed to Different Doses of 20E [0.03%]
不同剂量20E暴露下克氏原螯虾转录组和微生物组分析
Yan Zou,Chen-Yang Zhang,Xiao-Tong Cao et al.
Yan Zou et al.
Molting determines survival and growth in cultured crustaceans, yet its specific regulatory mechanisms remain complex. This study integrated transcriptomics and microbiome analyses to elucidate molting regulation in crayfish (Procambarus cl...
Optimizing Rat In Vitro Fertilization for Rat Model Cryo-Resuscitation from Frozen-Thawed Sperm [0.03%]
优化大鼠体外受精以建立冻融精子复苏的大鼠模型
Hongsheng Men,Payton S Oswalt,Elizabeth C Bryda
Hongsheng Men
Optimizing cryo-resuscitation from frozen sperm would improve access to cryopreserved rat models. In this study, the possibility of replacing intracytoplasmic sperm injection (ICSI) with in vitro fertilization (IVF) for model cryo-resuscita...
The Role of the Vaginal Microbiome in Gynecological Diseases: Mechanistic Insights and Emerging Interventions [0.03%]
阴道微生物组在妇科疾病中的作用：机制见解和新兴干预措施
Yiming Zhang,Tiantian Wei,Changying Zhao et al.
Yiming Zhang et al.
The vaginal microbiome (VM), a complex and dynamic microbial ecosystem, is now recognized as a central determinant of female reproductive and gynecologic health. Under homeostatic conditions, a Lactobacillus-dominant ecosystem maintains vag...
A Physics-Aware Diffusion Framework for Robust ECG Synthesis Using Mesoscopic Lattice Boltzmann Constraints [0.03%]
基于介观格子玻尔兹曼约束的物理感知扩散框架的鲁棒ECG合成方法
Xi Qiu,Hailin Cao,Li Yang et al.
Xi Qiu et al.
Cardiovascular disease has become the leading cause of death worldwide, underscoring the urgent need for widespread cardiac monitoring, while the Electrocardiogram (ECG) remains the diagnostic gold standard, the complexity of its acquisitio...
Comparative Analysis of Flesh Quality in Triploid and Allotetraploid Pengze Crucian Carp: Nutritional Composition, Flavor Profile, Texture Properties, and Metabolomics Insights [0.03%]
基于营养成分、风味轮廓、质地属性和代谢组学解析的彭泽鲫三倍体与同源四倍体肉质差异性评价
Gang He,Menglu Li,Wen Xie et al.
Gang He et al.
This study provides a systematic and multidimensional evaluation of flesh quality differences between triploid (T-PZ) and allotetraploid (A-PZ) Pengze crucian carp, addressing a significant gap in genetic improvement of this economically im...
Postbiotic Metabolites from a 31-Strain Lactobacillus/ Bifidobacterium Co-Culture Attenuate DSS Colitis with Barrier- and Circadian-Linked Transcriptomic Signatures [0.03%]
一种含31株乳酸菌/双歧杆菌混合培养衍生的益生元代谢产物可减弱DSS结肠炎并表现出屏障功能和昼夜节律相关的转录组特征
Shuhei Ueda,Takumi Iwasawa,Kaho Ohki et al.
Shuhei Ueda et al.
Postbiotics produced by beneficial bacteria are emerging as safe dietary approaches to intestinal inflammation. We evaluated intestinal bacterial metabolites (IBM), a cell-free fermented soybean extract generated by co-culturing 31 Lactobac...