Curcumin Enhances Gemcitabine Sensitivity in Breast Cancer Cells Through ROS-Associated Mitochondrial Apoptosis and Transcriptional Reprogramming [0.03%]
姜黄素通过ROS相关的线粒体凋亡和转录组重塑增强乳腺癌细胞对于吉西他滨的敏感性
Aşkın Evren Güler,Mehmet Cudi Tuncer,İlhan Özdemir
Aşkın Evren Güler
Breast cancer is a leading cause of cancer-related mortality in women, necessitating new treatment strategies. Curcumin (Cur), a natural polyphenol, and gemcitabine (Gem), a standard chemotherapeutic, were investigated for their combined an...
Integrative Advances in Pig Genomics: From Reference Assemblies and Evolutionary History to the Mechanistic Dissection of Key Traits [0.03%]
猪基因组学的综合进展：从参考基因组装配和进化历史到关键性状机制解析
Shengguo Tang,Dongfang Li,Ying Lu et al.
Shengguo Tang et al.
Pigs are a major source of animal protein and an important model for studying domestication, adaptation, and the genetics of complex traits. Over the past decade, pig genomics has progressed from generating reference assemblies and variant ...
From Molecular Cleavage to Clinical Effect: A Probabilistic Field Model of Botulinum Toxin Action [0.03%]
从分子切割到临床效果：肉毒杆菌毒素作用的概率场模型
Andrea Felice Armenti,Francesco Armenti
Andrea Felice Armenti
Botulinum toxin (BoNT) is a highly specific molecular enzyme whose therapeutic action is based on the proteolytic cleavage of SNARE proteins, most notably SNAP-25. Despite the deterministic nature of this molecular mechanism, the clinical e...
Genome-Wide Analysis of the TIFY Gene Family in Litchi (Litchi chinensis Sonn.): Identification and Expression Profiling [0.03%]
荔枝TIFY基因家族的鉴定及表达分析
Yuhu Tang,Xing Meng,Peidong Chen et al.
Yuhu Tang et al.
The TIFY family, known as a novel group of transcription factors unique to the plant, plays a number of roles and has been functionally characterized in numerous plant species. However, TIFY proteins remain unexplored in litchi. Here, we id...
Influence of Hypoxia, Dehydration and Salinity on Survival of Orthohalarachne Marine Mite Larvae: Limits to Dispersion [0.03%]
低氧、脱水和盐度对正盐稻属海螨幼虫存活的影响：扩散的限制
Lucía Pérez Zippilli,José Emilio Crespo,Juan Pablo Loureiro et al.
Lucía Pérez Zippilli et al.
Orthohalarachne attenuata and O. diminuata mites are parasites of the respiratory system of Pinnipeds. During hosts' dives, mites must cope with changing conditions of oxygen availability in the nasal cavity. Adults and nymphs live inside t...
Warming Drives the Reassembly of Carbon-Sequestering Microbial Communities in Alpine Lakeshore Wetland Without Altering Their Core Metabolic Functional Redundancy [0.03%]
升温驱动高山湖滨湿地固碳微生物群落的重建而不改变其核心代谢功能冗余性
Zhiyun Zhou,Ni Zhang,Wei Ji et al.
Zhiyun Zhou et al.
Climate warming is an important driver influencing soil microbial involvement in carbon cycling. To clarify the responses of carbon-fixing microorganisms in alpine lakeshore wetlands, we conducted a warming experiment using open-top chamber...
Protective Effects and Mechanisms of Taxus cuspidata Seed Oil on CCl4-Induced Hepatic Fibrosis in Mice [0.03%]
Taxus cuspidata种子油对四氯化碳致小鼠肝纤维化的保护作用及机制研究
Li Gao,Hui Tian,Xiangli Bai et al.
Li Gao et al.
This study aimed to investigate the effect and underlying mechanism of Taxus cuspidata seed oil (TCSO) on carbon tetrachloride (CCl4)-induced hepatic fibrosis in mice. A mouse model of hepatic fibrosis was established by CCl4 induction, and...
Age-Dependent Alterations in Intestinal Barrier Function: Involvement of Microbiota and TLR4 Signaling [0.03%]
年龄依赖性的肠屏障功能改变：肠道菌群和TLR4信号的参与
Yakun Xing,Xingyu Zhao,Xinyu Li et al.
Yakun Xing et al.
The intestinal barrier undergoes profound changes with age, impacting local immunity and systemic health, yet the mechanisms coordinating immune and microbial dynamics across the lifespan remain incompletely understood. Toll-like receptor 4...
Immunization with Recombinant TRP19 Reduces Clinical Severity of Experimental Ehrlichia canis Infection in Dogs [0.03%]
重组TRP19免疫可降低实验性犬埃利希体感染的临床严重性
Boondarika Nambooppha,Anucha Muenthaisong,Pongpisid Koonyosying et al.
Boondarika Nambooppha et al.
Canine monocytotropic ehrlichiosis (CME), caused by the intracellular bacterium Ehrlichia canis, is a significant tick-borne disease in dogs that requires effective vaccination strategies. This study aimed to evaluate recombinant TRP19 (rTR...
Global Patterns and Future Dynamics of Four Invasive Cocklebur Species Under Climate Change: Contrasting Climatic and Anthropogenic Drivers [0.03%]
全球变化下四种入侵苍耳的分布格局及未来动态：气候与人为因素的影响不容忽视
Yunzhi Sang,Xuan Li,Jianghua Zheng et al.
Yunzhi Sang et al.
Climate change, together with intensifying human activities, is reshaping global plant invasion dynamics and increasingly threatening ecosystem stability and biodiversity. Cockleburs are highly invasive weeds with strong ecological plastici...