Genome-Wide Identification and Functional Analysis of the CNGC Gene Family in Suaeda glauca [0.03%]
盐地碱蓬CNGC基因家族的鉴定及功能分析
Jun Wang,Chunxing Dong,Xiaoxue He et al.
Jun Wang et al.
Cyclic nucleotide-gated channel (CNGC) genes play key regulatory roles in plant immunity and abiotic stress responses. In this study, we conducted a genome-wide identification and analysis of the CNGC gene family in Suaeda glauca. A total o...
ATF4 Is Dispensable for Spermatogenesis but Protective Against ER Stress Under Normal Conditions [0.03%]
ATF4对于 spermatogenesis 是可有可无的，但在正常条件下对ER压力具有保护作用
Mingxing Zhang,Zhicheng Wu,Yilan Teng et al.
Mingxing Zhang et al.
Spermatogenesis is a metabolically intensive process that is highly sensitive to perturbations in proteostasis. The integrated stress response (ISR) and its central effector, ATF4, orchestrate adaptive responses to maintain cellular homeost...
Evolution and Comparative Analysis of Sheep Reference Genomes: From Fragmented Assemblies to Telomere-to-Telomere Genomics [0.03%]
羊参考基因组的演化与比较分析：从片段化组装到端粒到端粒基因组学
Dan Yue,Ying Lu,Yuqing Chong et al.
Dan Yue et al.
The reference genome serves as a fundamental resource for sheep genetic research and molecular breeding, and iterative improvements in assembly quality have directly driven advances in these fields. A systematic literature review was conduc...
Genetic Structure and Historical Dynamics of the Economic Species Phascolosoma esculenta in Southeastern China [0.03%]
中国经济动物europäischeRasterigelwurm（Phascolosoma esculenta）的遗传结构及历史动态
Bohua Ma,Jiajun Zhou,Guiqing Wu et al.
Bohua Ma et al.
Phascolosoma esculenta is an economic species endemic in China and a highly prized delicacy along the country's southeastern coast. This study focused on five P. esculenta populations and investigated their genetic diversity, population str...
Chronic TBPH Exposure Drives the Transition from Steatosis to Hepatic Fibrosis via Lipid Droplet Dysregulation in Zebrafish [0.03%]
慢性TBPH暴露通过脂滴失调驱动斑马鱼从肝脂肪变性到肝纤维化的转变
Yiming Liu,Dingxi Pan,Mingying Li et al.
Yiming Liu et al.
Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH) is a widely used novel flame retardant and an emerging ubiquitous environmental contaminant. While acute exposure disrupts lipid signaling, the long-term consequences of TBPH exposure on ...
Anti-Thrombotic Activities of Veratramine via Inhibiting Platelet Aggregation and FIIa/FXa [0.03%]
抑血小板聚集和FIIa/FXa活性的草乌甲素的抗栓作用机制研究
Gyuri Han,Ga Eun Kim,Dong Ho Park et al.
Gyuri Han et al.
Background: There is growing interest in plant-derived compounds for managing vascular diseases. Veratramine (VRT), a steroidal alkaloid isolated from plants of the Veratrum genus, exhibits diverse biological effects such...
Mechanisms Underlying Drought Adaptability in Duolang Sheep Based on Metabolomic and Transcriptomic Analyses [0.03%]
基于代谢组学和转录组学分析的独龙羊抗旱适应机制研究
Bingjie Jiang,Bin Chen,Yaling Yang et al.
Bingjie Jiang et al.
This study investigates the mechanisms underlying drought adaptability in Duolang sheep, a local breed from two distinct habitats in Xinjiang-an arid southern region and a grassland northern region-aiming to identify key factors driving dif...
Pan-Cancer Analysis of PAPPA Gene Reveals Tumor-Specific Prognostic Effects [0.03%]
泛癌症分析揭示PAPPA基因的肿瘤特异性预后作用
Samah Mutasim Alfadul,Khalid Omama,Alisa Y Potapova et al.
Samah Mutasim Alfadul et al.
Pregnancy-associated plasma protein A (PAPPA) is a metalloproteinase that regulates insulin-like growth factor availability via cleavage of IGF-binding proteins, yet its role in cancer remains incompletely understood. Using integrated publi...
Deciphering the Temporal Transcriptional Dynamics and Key Regulatory Networks of Pyrus betulifolia in Response to PEG-Induced Osmotic Stress [0.03%]
基于PEG诱导渗透胁迫的白梨转录组动态变化及潜在关键调控网络解析
Ziyi Zhang,Ke Li,Wenxuan Chu et al.
Ziyi Zhang et al.
Drought stress severely restricts the growth of pear trees. As a widely used drought-tolerant rootstock, Pyrus betulifolia exhibits stable growth performance; however, the molecular mechanisms underlying its drought tolerance remain to be e...
The lncRNA-DNA Methylation Axis in Hepatocellular Carcinoma: Mechanisms, Epigenetic Plasticity, and Biological Implications [0.03%]
肝癌中长链非编码RNA- DNA甲基化轴：机制、表观遗传可塑性和生物学意义
Lingke Meng,Lingzhu Cheng,Yuanyuan Li et al.
Lingke Meng et al.
DNA methylation is a fundamental epigenetic regulator in hepatocellular carcinoma (HCC). However, a key paradox remains: how do ubiquitously expressed enzymes like DNMTs and TETs achieve locus-specific regulation without intrinsic sequence ...