Long Non-Coding RNA-Derived Peptides as a Novel Source of Tumor Neoantigens: Expanding the Immunopeptidome Beyond Canonical Coding Regions [0.03%]
长非编码RNA衍生肽作为肿瘤新抗原的新型来源：超越经典编码区扩大免疫肽组学范围
Ismael López-Calvo,Inés Bao-Camacho,Samuel Martín-Revuelta et al.
Ismael López-Calvo et al.
Cancer immunotherapy has transformed the clinical management of several malignancies; however, its efficacy remains limited in tumors with low mutational burden and restricted availability of classical mutation-derived neoantigens. In this ...
Soil and Foliar Applications of Silicon Mitigate Biotic Stress in Cape Gooseberry Plants Caused by Fusarium Vascular Wilt [0.03%]
土壤和叶面施用硅可缓解秘鲁酸浆植物轮枝菌萎蔫病害造成的生物胁迫
David Sebastián Chitiva-Sánchez,Ana María Pérez-Rincón,Cristhian Camilo Chávez-Arias et al.
David Sebastián Chitiva-Sánchez et al.
Vascular wilt caused by Fusarium oxysporum f. sp. physali (Foph) severely limits cape gooseberry (Physalis peruviana L.) production in Andean regions, where management options are restricted and largely dependent on fungicides. Silicon (Si)...
CRISPR/Cas9-Mediated Polyketide Synthase Replacement for High-Yield Biosynthesis and Biological Activity of Milbemycin D [0.03%]
基于CRISPR/Cas9的聚酮合酶替换实现高效产生和研究光神霉素D及其生物活性
Shenchen Tao,Huan Qi,Xian Luo et al.
Shenchen Tao et al.
Milbemycin D is a promising 16-membered macrolide insecticide with reported superior efficacy, but its commercial development has been hindered by extremely low natural yields. This study aimed to construct a high-yielding microbial platfor...
Genome-Wide Identification and Characterization of the JMJ Histone Demethylase Gene Family in Maize (Zea mays L.) and Its Potential Role Under Drought Stress [0.03%]
玉米(JMJ组蛋白去甲基化酶基因家族的全基因组鉴定、特征分析及其潜在的干旱胁迫作用
Li Gao,Hui Tian,Xiangli Bai et al.
Li Gao et al.
Drought stress is a major abiotic factor limiting maize yield and stability. Although Jumonji C (JMJ) histone demethylases are known to regulate plant growth, development, and stress responses, their systematic characterization in maize has...
Integrated Genomic Analysis Unveils MicroRNA Roles in Glioma Development [0.03%]
整合基因组分析揭示微小核糖核酸在胶质瘤发生中的作用
Sevan Omer Majed,Gaylany H Abdullah,Kazhal Muhammad Sulaiman et al.
Sevan Omer Majed et al.
Gliomas are the most common type of primary brain tumors in adults, with a high level of recurrence and mortality. Their complex biology and adaptive resistance mechanisms pose major obstacles to existing treatment strategies. Non-coding RN...
Genetic Variants from Large Cohorts and Familial Studies Implicate Common Mechanisms in Schizophrenia [0.03%]
来自大规模队列和家系研究的遗传变异揭示了精神分裂症中的常见机制
Ambreen Kanwal,José V Pardo,Sadaf Naz
Ambreen Kanwal
Schizophrenia has an estimated population prevalence of 1%, but the etiology of this devastating psychiatric condition remains largely uncharacterized. A pronounced genetic component underlies schizophrenia, with heritability estimates rang...
Unveiling Key Biomarkers of Cardiovascular Risk in Psoriasis Through Explainable Artificial Intelligence [0.03%]
利用可解释的人工智能揭示银屑病心血管风险的关键生物标志物
Hasan Ucuzal,Mehmet Kıvrak
Hasan Ucuzal
Psoriasis patients face a significantly elevated risk of cardiovascular diseases (CVD), necessitating early and accurate risk prediction tools. This study developed and validated a machine learning model to predict CVD risk in psoriasis pat...
Evolution of Methods for the Quantitative Assessment of Inbreeding in Livestock [0.03%]
家畜近交评估的定量方法的发展
Lyubov Getmantseva,Siroj Bakoev,Maria Kolosova et al.
Lyubov Getmantseva et al.
Inbreeding is a quantitative measure of autozygosity that underlies the assessment of genetic risks and the management of genetic progress in livestock populations. The development of methods for its estimation reflects a transition from pr...
Toxicity Effects and Mechanism of Chemical Stress on Pomacea canaliculata [0.03%]
化学胁迫对福寿螺毒性效应及作用机理研究
Huayang Zhou,Meiling Zou,Zhixiong Zhou et al.
Huayang Zhou et al.
Pomacea canaliculata, as a significant invasive alien species, poses severe threats to agricultural development. Currently, chemical applications demonstrate notable efficacy in controlling this pest. However, metaldehyde exhibits overly si...
Inhibin Immunization to Enhance Reproductive Performance in Livestock: A Review [0.03%]
抑制素免疫接种提高家畜繁殖性能的研究进展综述
Abd Ullah,Muhammad Zahoor Khan,Changfa Wang
Abd Ullah
Reproductive efficiency substantially determines livestock productivity, and suboptimal fertility continues to limit productivity across species. Inhibin immunization represents a novel strategy to enhance fertility by neutralizing inhibin'...