DNMT/TET Imbalance and Network-Level DNA Methylation Remodeling in Ovarian Aging: Mechanistic Perspectives [0.03%]
卵子老化中DNA甲基化重编程的机制：DNMT / TET失衡和网络水平重塑视角
Miaofang Lin,Sheng Yang,Fengwen Huang et al.
Miaofang Lin et al.
Reproductive aging is characterized by progressive decline in ovarian reserve, reduced oocyte competence, and impaired endocrine coordination. Although these phenotypic changes are well documented, the molecular mechanisms that integrate ag...
Cytostatic and Non-Apoptotic Effects of Vinorelbine-Based Therapy in 3D Endometrial Cancer Spheroids [0.03%]
长春瑞滨对三维子宫内膜癌球体的细胞静止作用及非凋亡效应
Berna Yıldırım,Burcu Biltekin,Mete Hakan Karalök et al.
Berna Yıldırım et al.
Resistance to apoptosis represents a major therapeutic challenge in advanced and recurrent endometrial cancer. This study investigated whether vinorelbine, alone or in combination with lithium chloride (LiCl) or medroxyprogesterone acetate ...
Malaria in the 21st Century: Global Disease Burden, Epidemiological Insights, and Strategic Control Approaches [0.03%]
二十一世纪的疟疾：全球疾病负担、流行病学见解和战略控制方法
Basmah F Alharbi,Mawahib A Ahmed
Basmah F Alharbi
Malaria remains a major public health issue worldwide and a repeated cause of illness and death in tropical and subtropical areas. It is caused by protozoan parasites of the genus Plasmodium and transmitted through bites of infected female ...
Decoding Drug Resistance in Pancreatic Cancer: A Subcellular Structure Perspective [0.03%]
从亚细胞结构角度解读胰腺癌的药物耐受性问题
Xiaowen Li,Hao Lyu,Yixin Wu et al.
Xiaowen Li et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with drug resistance representing the primary barrier to effective treatment. Current research has largely focused on individual signaling pathways or isol...
Polyethylene Microplastics Exert Dose-Dependent Effects on the Growth, Physiology, and Rhizosphere Microbiome of Persicaria capitata [0.03%]
聚乙烯微塑料剂量依赖性地影响荞头的生长、生理及根系微生物组
Rou Ma,Ying Liu,Ruhuan Wang et al.
Rou Ma et al.
Microplastic pollution has become a major environmental challenge for terrestrial ecosystems; however, the mechanisms by which it affects the growth of medicinal plants and their rhizosphere microecology remain unclear. This study selected ...
Comparative Mitogenomic Analysis of Water Scavenger Beetles (Coleoptera: Hydrophiloidea) Provides Insights into Phylogeny and Adaptive Evolution [0.03%]
水 scavenger甲虫（coleoptera：hydrophiloidea）的比较线粒体基因组分析为其系统发育和适应性进化提供了见解
Huan Wang,Han-Hui-Ying Lv,Yi-Yang Zhao et al.
Huan Wang et al.
Water scavenger beetles (Coleoptera: Hydrophiloidea) exhibit remarkable adaptations to both aquatic and terrestrial habitats and play irreplaceable ecological roles, yet their higher-level phylogeny and the molecular basis of their adaptive...
Beyond Feature Selection: Interpretable Machine Learning for Mechanistic Insights in Metabolomics [0.03%]
面向机制阐释的代谢组学可解释机器学习方法研究（ beyond feature selection）
Haotian Bai,Yufei Ren,Jihan Wang et al.
Haotian Bai et al.
While metabolomics captures the dynamic chemical landscape of biological systems, its inherent high dimensionality and complexity pose significant analytical hurdles. Interpretable Machine Learning (IML) is revolutionizing the field by movi...
Variation in the Distribution Characteristics of Nemopilema nomurai in Relation to Marine Environmental Conditions [0.03%]
基于海洋环境因子的北太平洋墨乌贼分布特征变异分析
Sunyoung Oh,Kyoung Yeon Kim,Seok Hyun Youn et al.
Sunyoung Oh et al.
In this study, we examined the interannual distribution patterns of the giant jellyfish Nemopilema nomurai and their relationship with marine environmental factors using field survey data collected from the East China Sea from 2020 to 2024....
miRNA Sequencing and Differential Analysis of Testes from 1-Year-Old and 3-Year-Old Kazakh Horses [0.03%]
新疆哈萨克马1岁和3岁睾体差异miRNA的高通量测序分析
Qiuping Huang,Mingyue Wen,Liuxiang Wen et al.
Qiuping Huang et al.
This study aims to elucidate the miRNA regulatory mechanisms during the developmental process of Kazakh horse testes at 1 and 3 years of age. Through miRNA sequencing and bioinformatics analysis of testicular tissues from 1-year-old and 3-y...
Fan Li,Yura Son,Ming Yang et al.
Fan Li et al.
The regulation of the cardiomyocyte cell cycle is central to understanding heart regeneration. In adult mammals, cardiomyocytes withdraw from the cell cycle, limiting their ability to proliferate and repair heart tissue after injury. This p...