Pulsed Electromagnetic Field Therapy and Direct Current Electric Field Modulation Promote the Migration of Fibroblast-like Synoviocytes to Accelerate Cartilage Repair In Vitro [0.03%]
脉冲电磁场和直流电场通过调控滑膜成纤维细胞样细胞迁移促进软骨修复体外研究
Neeraj Sakhrani,Robert M Stefani,Stefania Setti et al.
Neeraj Sakhrani et al.
Articular cartilage injuries are a common source of joint pain and dysfunction. As articular cartilage is avascular, it exhibits a poor intrinsic healing capacity for self-repair. Clinically, osteochondral grafts are used to surgically rest...
Patient-Specific Inverse Modeling of In Vivo Cardiovascular Mechanics with Medical Image-Derived Kinematics as Input Data: Concepts, Methods, and Applications [0.03%]
基于医学图像的血管内心血管力学的逆向建模：概念、方法和应用
Johane H Bracamonte,Sarah K Saunders,John S Wilson et al.
Johane H Bracamonte et al.
Inverse modeling approaches in cardiovascular medicine are a collection of methodologies that can provide non-invasive patient-specific estimations of tissue properties, mechanical loads, and other mechanics-based risk factors using medical...
A 3D Printed Vitrification Device for Storage in Cryopreservation Vials [0.03%]
一种用于冷冻保存试管存储的三维印刷玻璃化设备
Yue Liu,Andy Lin,Terrence R Tiersch et al.
Yue Liu et al.
Sperm cryopreservation by vitrification is a promising approach for small-bodied animals such as zebrafish (Danio rerio). However, most vitrification tools adopted in aquatic research were initially designed for applications other than sper...
Ambulatory Monitoring of Subglottal Pressure Estimated from Neck-Surface Vibration in Individuals with and without Voice Disorders [0.03%]
正常人和嗓音障碍患者日常生活中的声门下压估测值监测研究
Juan P Cortés,Jon Z Lin,Katherine L Marks et al.
Juan P Cortés et al.
The aerodynamic voice assessment of subglottal air pressure can discriminate between speakers with typical voices from patients with voice disorders, with further evidence validating subglottal pressure as a clinical outcome measure. Althou...
Marek Franaszek,Jeremy A Marvel
Marek Franaszek
To ensure smooth robot operations, parameters of its kinematic model and a registration transformation between robot base and world coordinate frame must be determined. Both tasks require data acquired by external sensors that can measure e...
Mechanically Tunable Extracellular Matrix of Genipin Crosslinked Collagen and Its Effect on Endothelial Function [0.03%]
金丝桃素交联 collagen 的可调胞外基质及其对内皮功能的影响
Jacob Robinson,Teal Russell,Zhigang Xu et al.
Jacob Robinson et al.
Mechanical rigidity of a matrix, to which cells adhere, plays a significant role in regulating phenotypic cellular behaviors such as spreading and junction formation because vascular cells sense and respond to changes in their mechanical en...
Syntheses and Structure-Activity Relationships of N-Phenethyl-Quinazolin-4-yl-Amines as Potent Inhibitors of Cytochrome bd Oxidase in Mycobacterium tuberculosis [0.03%]
作为抑制胞膜辅酶Q分支细胞色素bd氧化酶的高效麦角生物碱，N-(苯乙基)喹唑啉-4-胺类化合物的合成及其构效关系研究
Sarah M Hopfner,Bei Shi Lee,Nitin P Kalia et al.
Sarah M Hopfner et al.
The development of cytochrome bd oxidase (cyt-bd) inhibitors are needed for comprehensive termination of energy production in Mycobacterium tuberculosis (Mtb) to treat tuberculosis infections. Herein, we report on the structure-activity-rel...
Yixuan Amy Pei,Ming Pei
Yixuan Amy Pei
Adult mesenchymal stem cells (MSCs) are prone to senescence, which limits the scope of their use in tissue engineering and regeneration and increases the likelihood of post-implantation failure. As a robust alternative cell source, fetal st...
Single Cell RNA-Sequence Analyses Reveal Uniquely Expressed Genes and Heterogeneous Immune Cell Involvement in the Rat Model of Intervertebral Disc Degeneration [0.03%]
单细胞核糖核酸序列分析揭示了大鼠椎间盘退化模型中独特表达的基因和异质性免疫细胞的参与情况
Milad Rohanifar,Sade W Clayton,Garrett W D Easson et al.
Milad Rohanifar et al.
Intervertebral disc (IVD) degeneration is characterized by a loss of cellularity, and changes in cell-mediated activity that drives anatomic changes to IVD structure. In this study, we used single-cell RNA-sequencing analysis of degeneratin...
Hyperparameter Tuning with High Performance Computing Machine Learning for Imbalanced Alzheimer's Disease Data [0.03%]
使用高性能计算机器学习进行不平衡阿尔茨海默病数据的超参数调整
Fan Zhang,Melissa Petersen,Leigh Johnson et al.
Fan Zhang et al.
Accurate detection is still a challenge in machine learning (ML) for Alzheimer's disease (AD). Class imbalance in imbalanced AD data is another big challenge for machine-learning algorithms working under the assumption that the data are eve...