Polyamine Depletion Strategies in Cancer: Remodeling the Tumor Immune Microenvironment to Enhance Anti-Tumor Responses [0.03%]
聚胺剥夺策略在癌症中的应用：重塑肿瘤免疫微环境以增强抗肿瘤反应
Alexander Chin,Charles J Bieberich,Tracy Murray Stewart et al.
Alexander Chin et al.
Polyamine biosynthesis is frequently dysregulated in cancers, and enhanced flux increases intracellular polyamines necessary for promoting cell growth, proliferation, and function. Polyamine depletion strategies demonstrate efficacy in redu...
The Incidence of Venous Thromboembolism in Critically Ill Patients with SARS-CoV-2 Infection Compared with Critically Ill Influenza and Community-Acquired Pneumonia Patients: A Retrospective Chart Review [0.03%]
SARS-CoV-2感染重症患者与流感和社区获得性肺炎重症患者血栓栓塞事件的对比研究：回顾性病历分析
Sean Boyd,Kai Sheng Loh,Jessie Lynch et al.
Sean Boyd et al.
The rate of venous thromboembolism in COVID-19 patients has been reported to be 30% (deep vein thrombosis 20% and pulmonary embolism 18%). This has been shown to be higher in COVID-19 patients admitted to the ICU. Prophylactic anticoagulati...
Connecting the Dots in Emerging Mast Cell Research: Do Factors Affecting Mast Cell Activation Provide a Missing Link between Adverse COVID-19 Outcomes and the Social Determinants of Health? [0.03%]
衔接新兴肥大细胞研究中的各个要素：影响肥大细胞活化的因素是否为不良COVID-19结果与健康社会决定因素之间的缺失环节？
Rachel da Silveira Gorman,Iffath Unissa Syed
Rachel da Silveira Gorman
Evidence continues to emerge that the social determinants of health play a role in adverse outcomes related to COVID-19, including increased morbidity and mortality, increased risk of long COVID, and vaccine adverse effects. Therefore, a mo...
Difluoromethylornithine (DFMO) Enhances the Cytotoxicity of PARP Inhibition in Ovarian Cancer Cells [0.03%]
左旋氨氯平(DFMO)可增强PARP抑制在卵巢癌细胞中的细胞毒性作用
Olivia El Naggar,Brenna Doyle,Kelsey Mariner et al.
Olivia El Naggar et al.
Ovarian cancer accounts for 3% of the total cancers in women, yet it is the fifth leading cause of cancer deaths among women. The BRCA1/2 germline and somatic mutations confer a deficiency of the homologous recombination (HR) repair pathway...
New Insights on the Toxicity on Heart and Vessels of Breast Cancer Therapies [0.03%]
关于乳腺癌治疗的心血管毒性的新认识
Oreste Lanza,Armando Ferrera,Simone Reale et al.
Oreste Lanza et al.
Cardiovascular diseases are largely represented in patients with cancer and appear to be important side effects of cancer treatments, heavily affecting quality of life and leading to premature morbidity and death among cancer survivors. In ...
Clinical Impact of Immune Checkpoint Inhibitor (ICI) Response, DNA Damage Repair (DDR) Gene Mutations and Immune-Cell Infiltration in Metastatic Melanoma Subtypes [0.03%]
免疫检查点抑制剂（ICI）反应、DNA损伤修复（DDR）基因突变和浸润性免疫细胞在转移性黑色素瘤亚型中的临床影响
Charlotte Andrieu,Niamh McNamee,Anne-Marie Larkin et al.
Charlotte Andrieu et al.
Molecular and histopathological analysis of melanoma subtypes has revealed distinct epidemiological, genetic, and clinical features. However, immunotherapy for advanced metastatic melanoma patients does not differ based on subtype. Response...
Mechanisms of Resistance to Second-Generation Antiandrogen Therapy for Prostate Cancer: Actual Knowledge and Perspectives [0.03%]
前列腺癌二线内分泌治疗耐药机制：现状及展望
Francesco Pinto,Francesco Dibitetto,Mauro Ragonese et al.
Francesco Pinto et al.
Prostate cancer therapy for locally advanced and metastatic diseases includes androgen deprivation therapy (ADT). Second-generation antiandrogens have a role in castration-resistant prostate cancer. Nevertheless, some patients do not respon...
Polyamine Metabolism in Leishmania Parasites: A Promising Therapeutic Target [0.03%]
利什曼原生动物聚胺代谢：有前景的治疗靶标
Nicola S Carter,Yumena Kawasaki,Surbhi S Nahata et al.
Nicola S Carter et al.
Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in humans and domestic animals worldwide. The need for new therapeutic strategies is urgent because no vaccine is available, and treatment options are...
Ursula Mirastschijski,Dongsheng Jiang,Yuval Rinkevich
Ursula Mirastschijski
Skin wound repair has been the central focus of clinicians and scientists for almost a century. Insights into acute and chronic wound healing as well as scarring have influenced and ameliorated wound treatment. Our knowledge of normal skin ...
Study on the Interaction between Serum Thyrotropin and Semen Parameters in Men [0.03%]
血清促甲状腺激素与男性精液参数相互作用的研究
Ioannis Kakoulidis,Ioannis Ilias,Stefanos Stergiotis et al.
Ioannis Kakoulidis et al.
The effect of thyroid function on semen parameters has been studied in pathological conditions in small studies. With this research work, we aimed to study thyroid hormone effects on semen parameters in 130 men who were evaluated for couple...