Understanding the Polyamine and mTOR Pathway Interaction in Breast Cancer Cell Growth [0.03%]
理解聚胺和mTOR信号通路在乳腺癌细胞生长中的相互作用
Oluwaseun Akinyele,Heather M Wallace
Oluwaseun Akinyele
The polyamines putrescine, spermidine and spermine are nutrient-like polycationic molecules involved in metabolic processes and signaling pathways linked to cell growth and cancer. One important pathway is the PI3K/Akt pathway where studies...
Acute Intravesical Capsaicin for the Study of TRPV1 in the Lower Urinary Tract: Clinical Relevance and Potential for Innovation [0.03%]
急性膀胱内注入辣椒素用于研究下尿路TRPV1的研究意义及创新潜能
Karl-Erik Andersson,Delphine Behr-Roussel,Pierre Denys et al.
Karl-Erik Andersson et al.
Capsaicin acts on sensory nerves via vanilloid receptors. TRPV1 has been extensively studied with respect to functional lower urinary tract (LUT) conditions in rodents and humans. We aimed to (1) provide background information on capsaicin ...
Vitamin D Supplementation in the Assessment of Cardiovascular Risk Factors in Overweight and Obese Children [0.03%]
维生素D补充对超重和肥胖儿童心血管风险因素的影响评估
Luca Pecoraro,Fulvio Nisi,Angela Serafin et al.
Luca Pecoraro et al.
Background: Childhood obesity is associated with cardiovascular-disease (CVD) risk factors, an unfavorable lipid profile and reduced levels of 25(OH)D. The aim of our study is to evaluate whether vitamin D supplementation may play a role in...
Observational Study
Medical sciences (Basel, Switzerland). 2022 Sep 5;10(3):49. DOI:10.3390/medsci10030049 2022
Medication-Wide Association Study Plus (MWAS+): A Proof of Concept Study on Drug Repurposing [0.03%]
药物再利用的 medication-wide association study plus（MWAS+）概念验证研究
Yan Cheng,Edward Zamrini,Ali Ahmed et al.
Yan Cheng et al.
The high cost and time for developing a new drug or repositioning a partially-developed drug has fueled interest in "repurposing" drugs. Drug repurposing is particularly of interest for Alzheimer's disease (AD) or AD-related dementias (ADRD...
Amelia B Furbish,Ahmed S Alford,Pieter Burger et al.
Amelia B Furbish et al.
The major intracellular polyamines spermine and spermidine are abundant and ubiquitous compounds that are essential for cellular growth and development. Spermine catabolism is mediated by spermine oxidase (SMOX), a highly inducible flavin-d...
Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease [0.03%]
vinculin与talin-1浓度在冠心病中的对比研究
Masayuki Aoyama,Yoshimi Kishimoto,Emi Saita et al.
Masayuki Aoyama et al.
Vinculin and talin-1, which are cytoskeletal proteins affecting focal adhesions, were reported to be down-expressed in atherosclerotic lesions. Recently, we reported high concentrations of plasma talin-1 in patients with coronary artery dis...
Elucidating the Role of Chmp1 Overexpression in the Transport of Polyamines in Drosophila melanogaster [0.03%]
阐明Chmp1过表达在果蝇Polyamine运输中的作用
Coryn L Stump,Robert A Casero Jr,Otto Phanstiel th et al.
Coryn L Stump et al.
Polyamines are small organic cations that are essential for many biological processes such as cell proliferation and cell cycle progression. While the metabolism of polyamines has been well studied, the mechanisms by which polyamines are tr...
Polyamine-Based Nanostructures Share Polyamine Transport Mechanisms with Native Polyamines and Their Analogues: Significance for Polyamine-Targeted Therapy [0.03%]
基于聚胺的纳米结构与天然聚胺及其类似物共享聚胺转运机制：对聚胺靶向治疗的意义
Cassandra E Holbert,Jackson R Foley,Ao Yu et al.
Cassandra E Holbert et al.
Polyamines are small polycationic alkylamines involved in many fundamental cellular processes, including cell proliferation, survival, and protection from oxidative stress. Polyamine homeostasis is tightly regulated through coordinated bios...
Multiple Asparaginase Infusions Cause Increasingly Severe Acute Hyperammonemia [0.03%]
多次注射天冬酰胺酶可导致急性血氨水平不断增加和严重中毒
Randal K Buddington,Karyl K Buddington,Scott C Howard
Randal K Buddington
Adverse reactions during and shortly after infusing asparaginase for the treatment of acute lymphoblastic leukemia can increase in severity with later doses, limiting further use and increasing relapse risk. Although asparaginase is associa...
Clinicopathological Characteristics and Overall 5-Year Survival of Colorectal Cancer: A Retrospective Study [0.03%]
结直肠癌的临床病理特征及总体五年生存率：回顾性研究
Rahaf Almuhanna,Fatma Al-Thoubaity,Khadijah Almalki et al.
Rahaf Almuhanna et al.
Colorectal cancer (CRC) is the third leading cause of cancer-related death. We aimed to investigate the clinicopathological characteristics and 5-year survival in CRC. This retrospective study reviewed King Abdulaziz University Hospital rec...