Combining Immune Checkpoint Inhibitors and Anti-Angiogenesis Approaches: Treatment of Advanced Non-Small Cell Lung Cancer [0.03%]
免疫检查点抑制剂与抗血管生成疗法联合治疗晚期非小细胞肺癌
Tate Barney,Anita Thyagarajan,Ravi P Sahu
Tate Barney
Combining immune checkpoint inhibitors (ICIs) and anti-angiogenic pharmacologic agents is an encouraging therapeutic approach in the treatment of non-small cell lung cancer (NSCLC). Currently, the only FDA-approved therapy combining an immu...
Current and Emerging Therapeutic Strategies for Limited- and Extensive-Stage Small-Cell Lung Cancer [0.03%]
局限性和广泛期小细胞肺癌的当前和新兴治疗策略
Walid Shalata,Rashad Naamneh,Wenad Najjar et al.
Walid Shalata et al.
Background: Small-cell lung cancer (SCLC) is a highly aggressive neuroendocrine malignancy characterized by rapid growth, early metastatic dissemination, and a dismal prognosis. For decades, treatment paradigms remained l...
Combined Use of Vitamin D and DPP-4 Inhibitors as a Potential Adjuvant Treatment Strategy to Enhance the Efficacy of Novel Beta-Cell Replacement Therapies for Type 1 Diabetes [0.03%]
维生素D和DPP-4抑制剂联合使用作为潜在的辅助治疗策略，以增强新型胰岛β细胞替代疗法对1型糖尿病疗效的补充治疗方法研究
Marcelo Maia Pinheiro,Felipe Moura Maia Pinheiro,Bruna Fioravante Di Serio et al.
Marcelo Maia Pinheiro et al.
Emerging evidence suggests that vitamin D and dipeptidyl peptidase-4 (DPP-4) inhibitors exert synergistic immunomodulatory, anti-inflammatory and antioxidant actions. Moreover, intervention studies showed that combination therapy based on t...
PROX1 Expression in Resected Non-Small Cell Lung Cancer: Immunohistochemical Profile and Clinicopathological Correlates [0.03%]
非小细胞肺癌切除标本中PROX1的表达及其临床病理意义
Evangelia Ntikoudi,Thomas Karagkounis,Konstantinos S Mylonas et al.
Evangelia Ntikoudi et al.
Background/Objectives: PROX1 (prospero homeobox 1) is a transcription factor involved in lymphangiogenesis and cellular differentiation. Its role in cancer biology appears to be highly context-dependent, with it exhibiting both tumor-promot...
Survival Patterns and Mortality Causes in Patients with Invasive Ependymoma: A Retrospective Cohort Analysis from 2000 to 2019 [0.03%]
侵袭性室管膜瘤患者的生存模式和死亡原因：2000-2019年回顾队列分析
Anas Elgenidy,Khaled Saad,Amir Aboelgheet et al.
Anas Elgenidy et al.
Background: Ependymomas are primary CNS neoplasms that arise from the ependymal cells of the brain and spinal cord, accounting for 3-6% of all CNS tumors. ...
An Interventional Study Exploring the Effects of Nutritional Psychoeducation on Emotional Eating After 3 Months [0.03%]
一项干预研究：探索营养心理教育对三个月后情绪性饮食的影响
Maria Mentzelou,Gavriela Voulgaridou,Konstantinos Papadimitriou et al.
Maria Mentzelou et al.
Background/Objectives: Emotional eating may be a consequence of acquired cue reactivity, a lack of control, or an inaccurate link between episodic overeating and negative affect, according to a new analysis of its standard measurement. This...
Randomized Controlled Trial
Medical sciences (Basel, Switzerland). 2025 Aug 16;13(3):138. DOI:10.3390/medsci13030138 2025
Effect of Spirulina platensis Versus Simvastatin on the Skeletal Muscles of Experimentally Induced Dyslipidemia: A Multitarget Approach to Muscle Ultrastructural and Cytomolecular Modulation [0.03%]
螺旋藻与辛伐他汀对实验性血脂异常骨骼肌的效应：肌肉超微结构及细胞分子多靶点调节作用的比较研究
Mai E Abdelhady,Khaled H Elmosalamy,Asmaa A A Kattaia et al.
Mai E Abdelhady et al.
Background/objectives: Dyslipidemia is a prevalent metabolic disorder closely linked to cardiovascular complications and muscular pathologies, often managed using statins such as simvastatin. However, statin-induced myopa...
Comparative Study
Medical sciences (Basel, Switzerland). 2025 Aug 15;13(3):137. DOI:10.3390/medsci13030137 2025
Preoperative Coagulation Markers and Clinical Predictors of Transfusion Requirement in Patients Undergoing Total Knee or Hip Arthroplasty: A Single-Center Retrospective Study [0.03%]
前瞻性单中心研究中全膝或髋关节置换术患者术前凝血指标和输血需求的临床预测因素
Wojciech Konarski
Wojciech Konarski
Background/Objectives: Total knee arthroplasty (TKA) and total hip arthroplasty (THA) are widely performed procedures often associated with significant blood loss, leading to the need for allogeneic blood transfusion. Transfusions carry inh...
Mechanisms of GLP-1 in Modulating Craving and Addiction: Neurobiological and Translational Insights [0.03%]
GLP-1调节渴望和上瘾的机制：神经生物学和转化见解
Gabriel Amorim Moreira Alves,Masatoki Teranishi,Ana Claudia Teixeira de Castro Gonçalves Ortega et al.
Gabriel Amorim Moreira Alves et al.
Substance use disorders (SUDs) remain a major public health challenge, with existing pharmacotherapies offering limited long-term efficacy. Traditional treatments focus on dopaminergic systems but often overlook the complex interplay betwee...
Smoking Behavior, Exposure to Second-Hand Smoke, and Attitudes Among Bulgarian and Foreign Medical Students [0.03%]
保加利亚和外国医学生的吸烟行为、被动吸烟及态度调查
Dolina Gencheva Gencheva,Fedya Petrov Nikolov
Dolina Gencheva Gencheva
Background: Cardiovascular morbidity and mortality are alarmingly high in Bulgaria, partly due to behavioral risk factors such as smoking. Purpose: This study aimed to assess and compare smoking habits, second-hand smoke exposure, and attit...