Virtual Biomarkers and Simplified Metrics in the Modeling of Breast Cancer Neoadjuvant Therapy: A Proof-of-Concept Case Study Based on Diagnostic Imaging [0.03%]
基于诊断影像的乳腺癌新辅助治疗建模中的虚拟生物标志物和简化指标：概念验证案例研究
Graziella Marino,Maria Valeria De Bonis,Marisabel Mecca et al.
Graziella Marino et al.
Background: Neoadjuvant chemotherapy (NAC) is a standard preoperative intervention for early-stage breast cancer (BC). Dynamic contrast-enhanced magnetic resonance imaging (CE-MRI) has emerged as a critical tool for evalu...
Effectiveness of Selenium Supplementation in the Treatment of Graves-Basedow Disease: A Scoping Review [0.03%]
硒补充治疗格雷夫斯-巴塞多病的疗效：系统综述
Hernando Vargas-Uricoechea,Alejandro Castellanos-Pinedo,Karen Urrego-Noguera et al.
Hernando Vargas-Uricoechea et al.
Background: Graves-Basedow disease (GBD) is an autoimmune thyroid disorder characterized by loss of tolerance to the thyrotropin receptor, with clinical manifestations such as a hyperadrenergic state, goiter, orbitopathy,...
Comparison of Risk Stratification Tools for Atherosclerotic Cardiovascular Disease and Cardiovascular-Kidney-Metabolic Syndrome in Primary Care [0.03%]
基层医疗中动脉粥样硬化性心血管疾病和心肾代谢综合征风险评估工具的比较研究
Victor Hugo Vázquez Martínez,Humberto Martínez Bautista,Patricia Muñoz Villegas et al.
Victor Hugo Vázquez Martínez et al.
Background/Objectives: Cardiovascular disease is the leading cause of death in Mexico; this is due to the high prevalence of chronic non-communicable diseases (NCDs), including obesity, type 2 diabetes mellitus (T2DM), systemic arterial hyp...
Observational Study
Medical sciences (Basel, Switzerland). 2025 Oct 23;13(4):240. DOI:10.3390/medsci13040240 2025
Immunoregulatory Imbalance in Preeclampsia: A Cross-Sectional Study of B7-H3 and Decidual NK Cell Interactions [0.03%]
子痫前期中B7-H3和蜕膜自然杀伤细胞的相互作用导致免疫调节失衡：横断面研究
Khanisyah Erza Gumilar,Alexander Indra Humala,Manggala Pasca Wardhana et al.
Khanisyah Erza Gumilar et al.
Background: Preeclampsia remains a leading cause of maternal and perinatal morbidity and mortality, yet its pathophysiology is not fully understood. Recent studies suggest that dysregulated maternal immune responses, part...
Emerging Innovations in the Treatment of Fuchs Endothelial Corneal Dystrophy: A Narrative Review [0.03%]
治疗Fuchs角膜内皮营养不良的新兴创新疗法：叙述性综述
Magdalena Niestrata,James Jackson,Shehnaz Bazeer et al.
Magdalena Niestrata et al.
Fuchs endothelial corneal dystrophy (FECD) is the leading cause of endothelial failure requiring keratoplasty in industrialised nations. Descemet membrane endothelial keratoplasty (DMEK) has become the gold-standard surgical therapy, yet it...
Subclinical Myocardial Dysfunction in Type 2 Diabetes Mellitus: Insights from Left Ventricular Diastolic Function and Global Longitudinal Strain Assessment [0.03%]
2型糖尿病患者心室收缩和舒张功能亚临床障碍的超声评价
Thao Phuong Nghiem,Hoang Minh Tran,Dung Ngoc Quynh Nguyen et al.
Thao Phuong Nghiem et al.
Background/objectives: Diabetic cardiomyopathy in type 2 diabetes mellitus (T2DM) often progresses silently, manifesting as diastolic dysfunction or subtle systolic impairment despite preserved ejection fraction (EF). Det...
Gut-Brain Axis and Perioperative Gut Microbiome in Postoperative Cognitive Dysfunction: Implications for Neurosurgical Patients [0.03%]
胃肠道-大脑轴和术后认知障碍的围手术期肠道菌群：神经外科患者的临床意义
Ismail A Abdullah,Sariya Khan,Fatma E Hassan
Ismail A Abdullah
Background: Postoperative cognitive dysfunction (POCD) is a common postoperative condition after neurosurgery, and in patients of advancing age, with far-reaching implications for recovery and quality of life. Current evidence points to the...
Optimizing Mycophenolate Therapy in Renal Transplant Patients Using Machine Learning and Population Pharmacokinetic Modeling [0.03%]
基于人群药代动力学和机器学习优化肾移植患者的霉酚酸治疗方案
Anastasia Tsyplakova,Aleksandra Catic-Djorđevic,Nikola Stefanović et al.
Anastasia Tsyplakova et al.
Background/objectives: Mycophenolic acid (MPA) is used as part of first-line combination immunosuppressive therapy for renal transplant recipients. Personalized dosing approaches are needed to balance efficacy and minimiz...
Ruperto González-Pérez,Ainhoa Escuela-Escobar,Mario A González-Carracedo et al.
Ruperto González-Pérez et al.
Background: Saharan dust intrusions (SDIs) are associated with poor air quality and adverse respiratory outcomes. However, their impact on real-world inhaler utilization remains insufficiently characterized. We aimed to e...
Incidence and Survival of IDH-Wildtype Glioblastoma and IDH-Mutant Astrocytoma by Treatment and Sex: A Regional Study in Spain (2011-2021) [0.03%]
西班牙（2011-2021年）按治疗和性别划分的IDH野生型胶质母细胞瘤和IDH突变型星形细胞瘤的发生率和生存研究
J A Encarnación,C Manso,M Royo-Villanova et al.
J A Encarnación et al.
Background: The incidence and prognosis of high-grade gliomas differ according to histopathological and molecular features. The WHO 2021 CNS classification emphasized IDH status, but historical cohorts often lacked system...