Revisiting the Antigen 85 Complex as a Target for Functional Antibody-Based Strategies Against Mycobacterium tuberculosis [0.03%]
Izat Smekenov,Nazym Tleumbetova,Sagit Bektassov et al.
Izat Smekenov et al.
The antigen 85 (Ag85) complex of Mycobacterium tuberculosis comprises secreted mycolyltransferases essential for cell wall biosynthesis and envelope integrity. Although extensively studied as immunodominant antigens and targets of small-mol...
Sampling Schemes in Poliovirus Wastewater Surveillance Studies from European Countries and Their Comparison to Other Studies: A Literature Review [0.03%]
Jan Rožanec,Veronika Učakar,Andrej Steyer et al.
Jan Rožanec et al.
Poliovirus wastewater surveillance (WWS) is an important complementary system to acute flaccid paralysis surveillance and a substitute surveillance for enteroviruses in stool samples of children, within global poliovirus eradication efforts...
Haotian Li,Wenbo Zhu,Tianen Hu et al.
Haotian Li et al.
The salinization of natural grasslands is a growing global concern. The Songnen Plain in northeastern China represents a typical soda-saline grassland region, yet an integrated understanding of how salinization reshapes plant, soil, and mic...
Historical Pandemic and Contemporary Influenza A Viruses Reveal PB2 M631L as a Convergent Adaptation to Human ANP32 [0.03%]
Matthias Budt,Irina Barac,Jessica Kohs et al.
Matthias Budt et al.
Understanding the genetic changes that allow avian influenza A viruses (IAVs) to switch their natural hosts and establish productive infection in humans is important for pandemic risk assessment. Adaptations in the IAV polymerase are requir...
Downstream Purification Strategies for Virus-like Particles: A Systematic Review of Structure Preservation, Impurity Control, and Viral Safety [0.03%]
Jingchao Zhang,Chen Chen
Jingchao Zhang
Virus-like particles (VLPs), nanoscale self-assembled structures lacking viral genetic material, have emerged as a versatile platform for vaccines, targeted delivery systems, and gene-editing applications owing to their strong immunogenicit...
Yulia Aleshina,Vladimir Frantsuzov,Alexander Lukashev
Yulia Aleshina
Human astroviruses are small, non-enveloped RNA viruses belonging to the family Astroviridae. Among the four species known to infect humans, the species Mamastrovirus hominis (the classical human astroviruses, formerly MAstV1) is associated...
Rigidifying Flexible Regions of a Bacterial Laccase Enables High-Temperature Aflatoxin B1 Degradation [0.03%]
Dongwei Xiong,Huiying Sun,Yuhang Sun et al.
Dongwei Xiong et al.
Aflatoxin B1 (AFB1) poses a serious threat to global food and feed safety. Laccase-based enzymatic degradation represents a promising green strategy for AFB1 removal; however, its industrial application is severely limited by the rapid ther...
Airborne Movement of Antibiotic Resistance Genes Between Livestock Stables and Farmers' Homes [0.03%]
Hesham Amin,Tina Šantl-Temkiv,Kai Finster et al.
Hesham Amin et al.
Antibiotic resistance genes (ARGs) are prevalent in livestock environments due to antimicrobial use, yet their airborne dispersal into human-occupied indoor spaces remains poorly characterized. We investigated whether airborne ARGs disperse...
Integrated Genomic and Functional Characterization of Lactiplantibacillus plantarum MS11 Reveals Multifunctional Metabolite Production from a High-Altitude Fermented Dairy Niche [0.03%]
Yixuan Lin,Qi Liang,Baotang Zhao et al.
Yixuan Lin et al.
Lactiplantibacillus plantarum MS11, isolated from traditionally fermented yak milk in the high-altitude Gannan region of the eastern Tibetan Plateau, was investigated for its technological and functional potential in food applications. Usin...
SARS-CoV-2 Effects on Respiratory and Neurological Systems: Morphological Findings and Gene Expression in K18-hACE2 Mice Model [0.03%]
Ana Luisa Teixeira de Almeida,Andréa Marques Vieira da Silva,Mariana Mello E Souza et al.
Ana Luisa Teixeira de Almeida et al.
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has revealed a complex interplay between respiratory and neurological manifestations. This study utilized K18-hACE2 transgenic mice to investigat...