Mechanisms and Management Strategies of Hepatocarcinogenesis Driven by Chronic Hepatitis B Comorbid with Type 2 Diabetes [0.03%]
Qin Lou,Jiarong Cai,Jianhua Yin
Qin Lou
Chronic hepatitis B (CHB) and Type 2 diabetes (T2DM) are major independent risk factors for Hepatocellular carcinoma (HCC). The bidirectional promotion between T2DM and CHB forms the biological basis for their synergistic carcinogenic effec...
Biochanin A Exerts Broad-Spectrum Antiviral Activity Against Coronaviruses via Activating the AMPK/Nrf2/GSH Pathway [0.03%]
Qisheng Lin,Fan Ji,Haiyan Shen et al.
Qisheng Lin et al.
Coronavirus infections pose a significant threat to both human and animal health, causing widespread morbidity, mortality, and substantial economic losses. While vaccines are crucial for prevention, their efficacy is often limited by the hi...
Serovars, Genetic Relatedness and Antimicrobial Resistance of Non-Typhoidal Salmonella in Poultry and Farm Workers in Southeastern Nigeria [0.03%]
Ifeyinwa R Okosi,Onyinye J Okorie-Kanu,Lynda Majesty-Alukagberie et al.
Ifeyinwa R Okosi et al.
Non-typhoidal Salmonella (NTS) is an important poultry-associated pathogen with major One Health and economic impacts, but data on its epidemiology and antimicrobial resistance in Nigeria remain limited. This study investigated the prevalen...
Ming Luo,Kristin V Lyles,Oluwafoyinsola O Faniyi et al.
Ming Luo et al.
Nucleocapsids protect viral genomes and play fundamental roles in viral assembly and infection. While many viruses adopt icosahedral or helical symmetries, negative-strand RNA viruses (NSVs) assemble their nucleocapsids with a distinct tran...
In Vitro Characterization of an Rgg-Family Regulator from Fish-Derived Streptococcus parauberis and Its Modulation by Cyclosporin A [0.03%]
Chuandeng Tu,Libin He,Xiangri Lin et al.
Chuandeng Tu et al.
Streptococcus parauberis is a major pathogen responsible for streptococcosis in both marine and freshwater fish species, causing substantial economic losses in aquaculture. The increasing prevalence of multidrug resistance has highlighted t...
Regulation of Peptaibol Profile by Velvet LAE1/VEL1 in Trichoderma Species During In Vitro Confrontations with Fusarium graminearum [0.03%]
Yaqian Li,Hui Zhang,Huimin Ji et al.
Yaqian Li et al.
Peptaibols, predominantly secreted by Trichoderma species, are a class of linear peptides composed of five to twenty amino acid residues, synthesized non-ribosomally and enriched with α-amino isobutyric acid. These unique peptides appear t...
Re-Emergence and Characterization of a Highly Pathogenic Getah Virus on a Pig Farm in Guangdong Province, China [0.03%]
Handuo Jia,Huahua Kang,Pinpin Chu et al.
Handuo Jia et al.
Getah virus (GETV), a mosquito-borne virus capable of infecting multiple economically important animal species, poses a potential epidemic risk. In May 2024, one pig farm from Heyuan, Guangdong Province, China, suffered reproductive disorde...
Eva Iniguez,Ana Victoria Ibarra-Meneses,Antonio Mastroianni et al.
Eva Iniguez et al.
Leishmaniasis is the term used to characterize a spectrum of human diseases caused by more than 20 different Leishmania parasite species [...].
HIV Reservoirs Across Multiple Tissues: From Heterogeneous Mechanisms to Therapeutic Targeting [0.03%]
Ya-Lan Wu,Gong-Wang Lan,Lin-Ying Jiang et al.
Ya-Lan Wu et al.
Despite effective antiretroviral therapy, HIV persists in diverse tissue reservoirs that pose major barriers to a cure. This review examines the heterogeneous maintenance mechanisms of HIV reservoirs in lymph nodes, intestinal mucosa, and t...
Assessment of the Safety and Potential Probiotic Properties of Lactiplantibacillus plantarum LP28 Based on Whole Genome Sequencing and Phenotypic and Oral Toxicity Analyses [0.03%]
Yi-Chu Liao,Yi-Chen Cheng,Chia-Chia Lee et al.
Yi-Chu Liao et al.
Lactiplantibacillus plantarum LP28 (LP28), isolated from traditional Taiwanese dried tofu, has been demonstrated to have substantial probiotic potential because it increases the production of short-chain fatty acids (SCFAs) and strengthens ...