Bench-to-Bedside Insights into the Challenges of Immunosuppression in Sepsis [0.03%]
从实验室到临床：探讨脓毒症免疫抑制的挑战
Shaowen Huang,Siyuan Huang,Xiaofei Huang et al.
Shaowen Huang et al.
Sepsis remains a leading cause of global mortality and is characterized by a dysregulated host immune response to infection. Early deaths often result from hyperinflammation and organ dysfunction, whereas late-stage mortality is increasingl...
Nasopharyngeal Swabs for Orientia tsutsugamushi Detection in Doxycycline Treatment: A Prospective Cohort Study in Hainan, China [0.03%]
中国海南省多西环素治疗区恙虫病耙抓拭子检测的鼻咽拭子前瞻性队列研究
Yuanze Chen,Siqi Chen,Jiajia An et al.
Yuanze Chen et al.
Scrub typhus, caused by Orientia tsutsugamushi, remains a neglected cause of acute febrile illness. Molecular testing of blood supports early diagnosis, yet once doxycycline is started, blood qPCR positivity can drop rapidly, complicating s...
Varicella-Zoster Virus and the Eye: Clinical Spectrum, Management, and Vaccination [0.03%]
带状疱疹病毒与眼部疾病：临床表现、治疗及疫苗接种
Wendong Gu,Yaru Zou,Mingming Yang et al.
Wendong Gu et al.
Varicella-Zoster Virus (VZV) is one of the most important pathogens in ophthalmology. Reactivation may involve the adnexa (blepharoconjunctivitis, pseudomembranous conjunctivitis), cornea (dendritic keratitis, nummular and necrotizing strom...
Relationship Between Mean Faecal Gastrointestinal Nematode Egg Excretion in Horses and Its Variability: Implications for Control [0.03%]
horses粪便中消化道线虫卵排除量的均值及其变化幅度之间的关系：对控制的意义
Jacques Cabaret,Cristina Guerrero Molina,Cintli Martínez-Ortiz-de Montellano et al.
Jacques Cabaret et al.
Faecal egg counts (FECs) are used to assess the intensity of gastrointestinal nematode (GIN) infections in herbivores. FEC distribution is aggregated, meaning that approximately 20% of animals harbour 80% of infections. In times of escalati...
Pathogenic Species of Botryosphaeriaceae Involved in Tree Dieback in an Urban Forest Affected by Climate Change [0.03%]
气候变化影响下的城市森林衰退中Botryosphaeriaceae属致病物种的参与作用
Alessandra Benigno,Viola Papini,Salvatore Moricca
Alessandra Benigno
Urban forests are highly valued for the multiple benefits they provide to city dwellers. The strategic provision of ecosystem services by these forests is threatened by climate change, warming conditions being responsible for heat waves and...
Assessment of Long-Term Sequelae After Severe Malaria: A Retrospective Study [0.03%]
严重疟疾后遗症的长期评估：一项回顾性研究
Florian Cardona,Laura Héritier,Sébastien Cortaredona et al.
Florian Cardona et al.
Background: Data on long-term sequelae after severe imported Plasmodium falciparum malaria in adults are scarce in non-endemic settings. We aimed to quantify early and medium term renal and neurological outcomes and ident...
Challenges and Solutions in pgRNA Measurement: Toward Improved Monitoring of Hepatitis B Therapy [0.03%]
pgRNA测量的挑战与解决方案：改善乙型肝炎治疗监测之路
Zhenkun Zhu,Jin Wu,Jinyuan Li et al.
Zhenkun Zhu et al.
Hepatitis B virus (HBV) pregenomic RNA (pgRNA), transcribed directly from nuclear covalently closed circular DNA (cccDNA), is an essential component in viral replication. The synthesis and encapsidation of pgRNA depend significantly on the ...
Autoantibodies and Molecular Mimicry in Alphavirus Chronic Arthritis: A Systematic Review [0.03%]
反转录病毒慢发关节炎的自身抗体和分子模拟：系统性综述
Nosipho Zanele Masoto,Felicity Jane Burt
Nosipho Zanele Masoto
Chronic arthritis following arthritogenic alphavirus infections presents symptoms resembling autoimmune rheumatic diseases, raising questions about the underlying mechanisms, including molecular mimicry and autoantibody production. This sys...
Discovery of Novel c-di-GMP-Related Genes in Leptospira interrogans [0.03%]
钩端螺旋体 interrogans 相关的第二信使 c-di-GMP 新结合蛋白的鉴定与功能分析
Anielle Salviano de Almeida Ferrari,Davi Gabriel Salustiano Merighi,Aline Biazola Visnardi et al.
Anielle Salviano de Almeida Ferrari et al.
Cyclic di-GMP (bis-(3'→5') cyclic dimeric guanosine monophosphate) is a ubiquitous bacterial second messenger that regulates a wide range of cellular processes, including biofilm formation, motility, virulence, and environmental adaptation...
Loss of TGME49_227100 (Glutaredoxin 5) Disrupts Oocyst Formation and Sporulation in Toxoplasma gondii [0.03%]
TGME49_227100（谷氧还蛋白5）的丢失会破坏刚地弓形虫卵囊形成和孢子化过程
Fujie Xie,Yuehua Xie,Yilin Yang et al.
Fujie Xie et al.
Oocysts of Toxoplasma gondii exhibit remarkable resistance to environmental stressors and most conventional disinfectants. Despite its ability to infect a wide variety of host species, sexual reproduction and oocyst formation occur exclusiv...