Gut Microbiota Biomarkers in Patients with Hepatocellular Carcinoma in the Era of Immune Checkpoint Inhibitors [0.03%]
免疫检查点抑制剂时代肝细胞癌患者肠道微生物群标志物分析
Maria Cerreto,Marta Maestri,Maria Pallozzi et al.
Maria Cerreto et al.
Immune checkpoint inhibitors (ICIs) have revolutionized the therapeutic landscape for hepatocellular carcinoma (HCC); however, a considerable proportion of patients do not achieve durable clinical benefits. This highlights the need for reli...
First Occurrence of Wronascolex sp. (Palaeoscolecida, Priapulida) in the Cambrian Tianpeng Formation (Wuliuan Stage), Southeastern Yunnan, South China: Implications for a New Burgess Shale-Type Lagerstätte [0.03%]
中国华南云贵地区乌溜龄天蓬 Formation 寒武纪腕刺动物新属种 Wronascolex 首次发现及一类布尔吉斯页岩型特异埋藏化石库的出现与意义
Shang-Yun-Zhi Xiao,Liu-Run-Xuan Chen,Shi-Tao Zhang et al.
Shang-Yun-Zhi Xiao et al.
We report the discovery of a new palaeoscolecid worm specimen from the Bainiuchang area, southeastern Yunnan, China. The specimen exhibits a cylindrical body with annulations, each bearing two rows of Hadimopanella-type sclerites, along wit...
Upper Esophageal Perforation with Cervico-Mediastinal Extension Successfully Treated with Endoluminal Vacuum Therapy: A Case Report Highlighting Inflammatory Marker Dynamics [0.03%]
内镜下真空封闭治疗上食道穿孔伴纵隔积脓1例并探讨炎性标志物的动态变化规律
Bogdan Mihnea Ciuntu,Edwina-Elena Viciriuc,Andreea Ludusanu et al.
Bogdan Mihnea Ciuntu et al.
Background: Upper esophageal perforations are life-threatening conditions associated with a high risk of mediastinitis, sepsis, and multiorgan failure. Standard management often requires extensive surgical intervention, which carries substa...
Gravity as a Boundary Condition for the Evolution of Three-Dimensional Multicellularity [0.03%]
万有引力与三维多细胞生物的进化边界条件关系研究
Oliver Ullrich,Cora S Thiel
Oliver Ullrich
Life evolved under a persistent 1 g field that is continuous, ubiquitous, and directionally structured. Here, we synthesize evidence across evolutionary biology, mechanobiology, and genome architecture to propose gravity as a mechanical bou...
Periodontitis Severity and Subgingival Microbiome Variation in Postmenopausal Women: A Stratified Case-Control Study [0.03%]
绝经后妇女牙周炎严重程度与牙周微生物群变化：一项分层病例对照研究
Irina-Georgeta Sufaru,Stefan-Lucian Burlea,Maria-Alexandra Martu et al.
Irina-Georgeta Sufaru et al.
Background: This study aimed to determine whether osteoporosis is associated with differences in the subgingival microbiome of postmenopausal women, stratified by periodontitis stage. ...
Bacillus subtilis Biofertilizer Mitigates N2O Emissions from Saline-Alkali Farmland [0.03%]
芽孢杆菌生物肥料缓解盐碱地农田的N2O排放作用
Rui Li,Xingjie Lin,Yu Miao et al.
Rui Li et al.
Nitrous oxide (N2O) emissions from agricultural soils are an important source of greenhouse gases and are strongly influenced by fertilization practices. In this study, a field experiment was conducted from 24 June to 12 October 2024, at a ...
Impact of PD-L1 Status on the Development of Cutaneous Immune-Related Adverse Events in Non-Small-Cell Lung Cancer Patients Receiving Immunotherapy [0.03%]
PD-L1状态对免疫治疗非小细胞肺癌患者皮肤免疫相关不良事件的影响研究
Alexander Yakobson,Fahed Abu Salamah,Ibrahim Alatawneh et al.
Alexander Yakobson et al.
Background: Cutaneous adverse events (cAEs) are among the most frequent immune-related toxicities associated with immune checkpoint inhibitors (ICIs). Previous clinical trials have reported higher rates of dermatologic toxicity with anti-CT...
Case Report: Hemidiaphragm Paralysis Results in Reduced Blood Oxygen Saturation, Increased Respiratory Rate, and Severe Dyspnea in Supine and Prone Positions due to Impaired Abdominal Breathing [0.03%]
个例报告：腹式呼吸障碍导致半膈神经麻痹，卧位和趴卧位时血氧饱和度降低、呼吸频率增加和严重呼吸困难
Akos Koller,Szonja Decker,Johanna Takács et al.
Akos Koller et al.
Background: The breathing cycle consists of abdominal breathing (AB), for which the diaphragm is responsible, and thoracic breathing (TB), generated by the intercostal muscles. Contraction of the two portions of the diaphragm accounts for 8...
Integrated Clinical, Molecular, and Machine Learning Assessment of Familial Hypercholesterolemia [0.03%]
集家族性高胆固醇血症的临床、分子和机器学习评估于一体的方法研究
Mustafa Tarık Alay,Atakan Deniz,Hanife Saat et al.
Mustafa Tarık Alay et al.
Background: In clinical practice, LDL-dominant familial hypercholesterolemia (FH) may overlap phenotypically with triglyceride-dominant or mixed familial dyslipidemia. Rule-based diagnostic approaches like the Dutch Lipid Clinic Network (DL...
Injury Epidemiology in Elite U17 Football Players: A Prospective Study Across Six Competitive Seasons [0.03%]
一项针对精英U17足球运动员六赛季的损伤流行病学前瞻性研究
Tomislav Pranjić,Frane Žuvela,Toni Modrić et al.
Tomislav Pranjić et al.
Injuries in elite youth football may disrupt training continuity and long-term development, particularly during the post-peak height velocity (post-PHV) period when training and match demands increase. Therefore, the aim of this study was t...