Dynamics of Postmortem Gene Expression in Normal and Neoplastic Murine Liver [0.03%]
正常和肿瘤小鼠肝脏中死后基因表达的动态变化规律
Evgeny E Buyko,Ekaterina A Perina,Danil S Sobakin et al.
Evgeny E Buyko et al.
The use of postmortem (autopsy) material in fundamental and applied biomedical research significantly facilitates the collection of biomaterial for statistically robust sample cohorts. However, natural adaptive processes to developing cellu...
Beyond Blood Pressure: Arterial Stiffness as a Hemodynamic and Neuroadrenergic Axis Linking Hypertension, Cardiac Remodeling, and Heart Failure [0.03%]
超越血压：动脉僵硬度作为血流动力学和肾上腺素能轴，连接高血压、心脏重塑和心力衰竭的关系
Pasquale Ambrosino,Cesare Cuspidi,Claudio Candia et al.
Pasquale Ambrosino et al.
Arterial stiffness has traditionally been interpreted as a marker of vascular ageing and cumulative blood pressure exposure. Increasing evidence, however, indicates that it should be viewed as an active determinant of cardiovascular loading...
Artificial Intelligence for Biomedical Diagnostics: Diagnostic Accuracy and Reliability of Multimodal Large Language Models in Electrocardiogram Interpretation [0.03%]
用于生物医学诊断的人工智能：多模态大型语言模型在心电图解读中的准确性与可靠性
Henrik Stelling,Armin Kraus,Gerrit Grieb et al.
Henrik Stelling et al.
The electrocardiogram (ECG) is a central tool in cardiovascular diagnostics, yet interpretation requires expertise and remains subject to variability. Multimodal large language models (MLLMs) have shown emerging capabilities in medical imag...
Agreement Between Non-Cycloplegic Photorefraction and Retinoscopy in Pediatric Refraction [0.03%]
非环鞘检影与视网膜检影的儿科验光结果一致性分析
Ana Roque,Amélia Fernandes Nunes,Henrique Nascimento et al.
Ana Roque et al.
Accurate assessment of refractive error in children is essential for clinical decision-making, yet agreement between non-cycloplegic techniques remains uncertain, particularly due to differences in accommodative demand. This study evaluated...
Revisiting Colon Cancer Progression: A Containment-Based Conceptual Framework [0.03%]
结直肠癌进展的再思考：一种基于抑制作用的概念框架
Roxana Loriana Negrut,Adrian Cote,Adrian Marius Maghiar
Roxana Loriana Negrut
Patterns of colon cancer recurrence demonstrate a high degree of anatomical reproducibility, consistently aligning with mesofascial planes and compartmentalized vascular and lymphatic territories, as evidenced by pathological, surgical and ...
Adjunctive Use of VGH4 for Moderate-to-Severe Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Crossover Pilot Trial [0.03%]
VGH4作为辅助疗法治疗中重度特应性皮炎的疗效和安全性：随机、双盲、安慰剂对照交叉试点试验
Ying-Ju Liao,Ta-Peng Wu,Chou-Cheng Lai et al.
Ying-Ju Liao et al.
Moderate-to-severe atopic dermatitis (AD) requires safe, long-term management strategies to complement conventional pharmacotherapy. This study evaluated the efficacy and safety of VGH4, a standardized multi-herb traditional Chinese medicin...
Distal Ureteral Stricture Secondary to Urolithiasis: Stepwise Endourological and Surgical Management with Ureteral Reimplantation and Drug-Coated Balloon Dilation (Optilume) [0.03%]
尿路结石所致远端输尿管狭窄的步步治疗：输尿管再植和药物涂层球囊扩张（Optilume）手术
Patricia Rodriguez-Parras,Ana Morales-Martinez,Alberto Zambudio-Munuera et al.
Patricia Rodriguez-Parras et al.
Introduction: Acquired ureteral stricture is an uncommon but clinically relevant complication, mainly associated with long-standing urolithiasis, chronic inflammatory processes, and repeated endourological procedures. ...
An Exploratory Study of Matrix Metalloproteinase Protein Changes in Unexplained Infertility [0.03%]
不明原因不孕患者基质金属蛋白酶变化的探索性研究
Zainab Alhalwachi,Thozhukat Sathyapalan,Stephen L Atkin et al.
Zainab Alhalwachi et al.
Background: Matrix metalloproteinases (MMPs) have been found to be associated with reproductive complications, including female infertility. This study was conducted to explore the link between MMPs in non-obese women with unexplained infer...
Features of Cross-Seeding of Wild-Type Alpha-Synuclein and Its Mutant Form A53T Potentially Useful for the Development of Test Systems [0.03%]
野生型α-突触核蛋白及其A53T突变体的跨种子特性可能有助于检测系统的开发
Kseniya Barinova,Sofiya Kudryavtseva,Lidia Kurochkina et al.
Kseniya Barinova et al.
Since the features of cross-seeding of alpha-synuclein forms may affect the sensitivity and specificity of the test systems, we developed a modified approach to obtain alpha-synuclein amyloid seeds with particle sizes from 20 to 50 nm prepa...
Rejection-Focused Precision Medicine in Kidney Transplantation: Biology, Biomarkers, and Artificial Intelligence [0.03%]
基于精准医学的肾脏移植排斥反应研究：生物学、生物标志物和人工智能
Luis Ramalhete,Rúben Araújo,Miguel Bigotte Vieira et al.
Luis Ramalhete et al.
Chronic kidney disease is rising worldwide, and kidney transplantation remains the preferred modality of kidney replacement therapy. However, long-term graft survival continues to be limited by chronic alloimmune injury, particularly antibo...