Pharmacologic Resistance in Soft Tissue Sarcomas: Mechanisms, Biomarkers, and Translational Therapeutic Strategies [0.03%]
软组织肉瘤的药理学耐药性：机制、生物标志物和转化治疗策略
Dorian Yarih García-Ortega,Gabriela Alamilla-García,Kevin Fernando Reyna-Pérez et al.
Dorian Yarih García-Ortega et al.
Soft tissue sarcomas are rare, biologically diverse mesenchymal malignancies in which pharmacologic resistance cannot be explained by a single unifying mechanism. In this narrative review, resistance is conceptualized as a dynamic, multilay...
High Prevalence of Superficial Metastases Supports Percutaneous Ultrasound-Guided Biopsy for Diagnosis and Molecular Profiling of Advanced Lung Cancer: Results from a Prospective Cohort [0.03%]
高比例的浅表转移支持经皮超声引导活检在晚期肺癌诊断和分子分型中的应用：一项前瞻性队列研究的结果
Marta Viscuso,Vanina Livi,Giovanni Sotgiu et al.
Marta Viscuso et al.
Background: Despite therapeutic advances, many patients with metastatic lung cancer still lack access to comprehensive molecular profiling, often due to inadequate biopsy samples. Percutaneous ultrasound-guided needle aspiration biopsy (US-...
A Systematic Literature Review of the Effectiveness of CDK 4/6 Inhibitors for First-Line Treatment of HR+/HER2- Advanced/Metastatic Breast Cancer: A Comparison of Real-World Evidence [0.03%]
CDK 4/6抑制剂一线治疗HR+/HER2-晚期或转移性乳腺癌有效性的系统评价：真实世界证据对比分析
Timothy Pluard,Thomas Grinda,Rodrigo Dienstmann et al.
Timothy Pluard et al.
Background/Objective: Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are the standard first-line treatment for HR+/HER2- advanced/metastatic breast cancer (a/mBC), yet no head-to-head randomized trials have...
TROP2 Is Uniformly Expressed in Primary Prostate Cancer but Frequently Reduced in Recurrent Disease [0.03%]
TROP2在原发前列腺癌中均匀表达但在复发病例中经常降低表达
Jonathan Jeutner,Ronald Simon,Maximilian Lennartz et al.
Jonathan Jeutner et al.
Background: TROP2 (TACSTD2) is a therapeutic target of antibody-drug conjugates and is broadly expressed in epithelial malignancies. Data on TROP2 protein expression in large, clinically annotated prostate cancer cohorts, particularly in re...
Cancer-Associated Fibroblast Heterogeneity and Extracellular Matrix Remodeling as Orchestrators of Drug Resistance in Upper Gastrointestinal Cancers: Insights from Spatial Multi-Omics and Therapeutic Implications [0.03%]
癌相关成纤维细胞异质性和细胞外基质重塑在上消化道癌症药物抵抗中的作用：空间多组学视角及治疗意义
Yasamin Mirzabeigi,Joe Youssef,Jeffrey Gonzalez et al.
Yasamin Mirzabeigi et al.
Upper gastrointestinal (GI) cancers, including esophageal, gastric, and pancreatic cancers, remain among the most lethal malignancies worldwide, mainly because they resist nearly every therapeutic modality, from platinum-based chemotherapy,...
Expression of Concern: Park et al. Isorhamnetin Induces Cell Cycle Arrest and Apoptosis Via Reactive Oxygen Species-Mediated AMP-Activated Protein Kinase Signaling Pathway Activation in Human Bladder Cancer Cells. Cancers 2019, 11, 1494 [0.03%]
表达关注：Park 等人在人类膀胱癌细胞中，山柰酚通过活性氧介导的AMP活化蛋白激酶信号通路诱导细胞周期停滞和凋亡。Cancers 2019, 11, 1494
Cancers Editorial Office
Cancers Editorial Office
With this notice, the Cancers Editorial Office alerts readers to concerns regarding this article [...].
Bridging Targeting Precision and Oncologic Safety: Localization Accuracy for Margin Adequacy in Cone-Beam Computed Tomography-Guided Pulmonary Nodule Resection [0.03%]
基于锥形束CT引导的肺结节切除术的切缘准确度定位精度：精确与安全性的折中取舍
Yu-Hsiang Wang,Hsu-Chih Huang,Chih-Yi Chen et al.
Yu-Hsiang Wang et al.
Background/Objectives: Ground-glass pulmonary nodules are often nonpalpable and not visible during thoracoscopic surgery, making accurate localization important for achieving adequate pathological margins. However, no clinically validated l...
High-Concentration Capsaicin Patch and Oral Pregabalin as Second-Line Therapy for Intercostobrachial Neuralgia After Breast Cancer Surgery: Open-Label Follow-Up of a Multicenter Randomized Controlled Clinical Trial [0.03%]
辣椒素贴剂和(pregabalin)口服治疗乳腺手术后肋臂神经痛的二线疗效：多中心随机对照临床研究的开放标签随访研究
Denis Dupoiron,Florent Bienfait,Valérie Seegers et al.
Denis Dupoiron et al.
Background: The CAPTRANE trial evaluated the efficacy of randomly assigned high-concentration capsaicin patch (HCCP) versus daily oral pregabalin (PGB) in adults with chronic neuropathic pain (DN4 ≥ 4) post-breast cancer...
Palliative Systemic Therapy in Advanced Thymic Epithelial Tumors in 2026-A Narrative Review [0.03%]
2026年晚期胸腺上皮肿瘤的姑息性全身治疗-叙述性回顾
Felix C Saalfeld,Tobias R Overbeck
Felix C Saalfeld
Palliative systemic therapy for advanced thymic epithelial tumors (TET) is challenging due to scarce evidence and biological heterogeneity. Scientific discussion, as in this review, is limited to cross-trial comparisons of small, non-random...
Impact of COPD on Outcomes After Pulmonary Metastasectomy: A Propensity-Score Matched Analysis [0.03%]
慢性阻塞性肺疾病对肺转移瘤切除术后预后影响的倾向性匹配分析
Konstantinos Grapatsas,Fabian Doerr,Roemer van Wijk et al.
Konstantinos Grapatsas et al.
Background: Pulmonary metastasectomy (PM) is an established component of multimodal oncological treatment, but its perioperative safety and long-term outcomes in patients with chronic obstructive pulmonary disease (COPD) ...