The Burden of Liver Cancer in Selected East Asian Countries (1990-2021) and Projections up to 2036: A Systematic Analysis of the Global Burden of Disease Study 2021 [0.03%]
全球疾病负担研究（2021）中 selected 东亚国家肝癌负担(1990-2021)及其至2036年的趋势预测：一项系统性分析
Tianhao Guo,Yu Zhao,Linyu Xu et al.
Tianhao Guo et al.
Background: Liver cancer remains a persistent global health challenge due to its high occurrence and fatality rates, critically impacting health outcomes and quality of life. The disease burden in East Asia, considering China, Japan, South ...
CCL5 Orchestrates Paradoxical Immune Landscapes in NSCLC: Simultaneous Recruitment of Effector and Suppressor Cells Shapes Immunotherapy Resistance [0.03%]
CCL5在NSCLC中统筹矛盾的免疫景观：同时募集效应细胞和抑制细胞塑造免疫治疗耐药性
Shuzhan Li,Jiali Zhang,Yang Wang et al.
Shuzhan Li et al.
Background: The chemokine CCL5 exhibits a complex role in cancer immunotherapy, yet its dual immunomodulatory functions in non-small cell lung cancer (NSCLC) remain poorly understood. Methods and Results: Based on a newly analyzed clinical ...
Real-World Outcomes of Palbociclib with Endocrine Therapy in HR+/HER2- Metastatic Breast Cancer: A Retrospective Study from Saudi Arabia [0.03%]
帕博西利联合内分泌治疗HR+/HER2-转移性乳腺癌的现实世界结局：沙特阿拉伯一项回顾性研究
Abdalrhman H Alanizi,Sarah N Al-Shaiban,Reema Alotaibi et al.
Abdalrhman H Alanizi et al.
Background: Hormone receptor-positive (HR+), Human Epidermal growth factor Receptor 2 (HER2-negative) metastatic breast cancer (MBC) represents a substantial proportion of breast cancer cases in Saudi Arabia. Despite the established efficac...
Extracellular Vesicle-Associated miRNAs in Glioblastoma: Mechanisms, Biomarkers, Therapies, and Links to Neurodegeneration [0.03%]
胶质母细胞瘤中的胞外囊泡相关miRNA：机制、生物标志物、治疗和与神经退行性疾病的关系
Chun Li,Takahiro Ochiya
Chun Li
Extracellular vesicles (EVs) facilitate intercellular communication in glioblastoma (GBM) by transferring microRNAs (miRNAs). GBM is the most aggressive primary brain tumor in adults, and despite multimodal therapy, the median survival rema...
Clinical Outcomes of Peptide Receptor Radionuclide Therapy in Japanese Patients with Metastatic Rectal Neuroendocrine Tumors [0.03%]
肽受体放射性核素治疗在日本转移性直肠神经内分泌肿瘤患者中的临床疗效分析
Takeshi Iizuka,Noritoshi Kobayashi,Damian Wild et al.
Takeshi Iizuka et al.
Background/Purpose: Rectal neuroendocrine tumors (NETs) with distant metastases are uncommon, and evidence supporting the effectiveness of peptide receptor radionuclide therapy (PRRT) in this population remains limited, particularly in Asia...
Christos Veros,Aristotelis Bamias
Christos Veros
Kidney Injury Molecule-1 (KIM-1), a type I transmembrane glycoprotein, is emerging as a promising biomarker in the landscape of genitourinary malignancies. Initially it was described for its role in renal tubular injury, but it is currently...
Comparing Response Evaluation Methods for PRRT in Neuroendocrine Tumors: Insights from an Exploratory Study [0.03%]
一种用于神经内分泌肿瘤肽受体放射性核素治疗反应评估方法比较的探索性研究见解
Priscilla Guglielmo,Carlo Carnaghi,Alexia Francesca Bertuzzi et al.
Priscilla Guglielmo et al.
Background/Objectives: Assessing treatment response in neuroendocrine tumors (NETs) remains challenging. The multifactorial mechanism of action of peptide receptor radionuclide therapy (PRRT) further complicates response evaluation, particu...
Multicenter Study of Multimodal MRI Radiomics and Deep Learning-Based Segmentation for Predicting Local Recurrence of Nasopharyngeal Carcinoma [0.03%]
基于多模态MRI影像组学和深度学习分割的鼻咽癌局部复发预测的多中心研究
Dongfang Yao,Yongjing Lai,Xiang Bin et al.
Dongfang Yao et al.
Background/Objectives: We developed and validated a multimodal magnetic resonance imaging (MRI) framework combining deep learning segmentation with radiomics to predict local recurrence in nasopharyngeal carcinoma (NPC). Methods: This retro...
TIMP1 and DPP4 Promote Tumor Progression by Regulating Lactate Metabolism in Papillary Thyroid Carcinoma [0.03%]
TIMP1和DPP4通过调节乳酸代谢促进乳头状甲状腺癌进展
ShiJi Mu,Jin Xue,Fada Xia et al.
ShiJi Mu et al.
Objectives: The mechanism of action of genes related to lactate metabolism in papillary thyroid carcinoma (PTC) is still unclear. In this study, key genes that play a role in PTC were selected from the known genes related to lactate metabol...
Phase II Study of Dose-Escalated and Convergent Stereotactic Body Radiotherapy for Liver and Pulmonary Oligometastases from Colorectal Cancer [0.03%]
立体定向体部放射治疗剂量escalation和收敛治疗结直肠癌肝肺寡转移的II期临床研究
Shuichi Nishimura,Atsuya Takeda,Yuichiro Tsurugai et al.
Shuichi Nishimura et al.
Purpose: Surgical resection of liver or pulmonary oligometastases (LP-OMD) in colorectal cancer (CRC) has been shown to improve survival. Stereotactic body radiotherapy (SBRT) is a promising alternative for patients with ...