Transcriptome-Metabolome Integration Deciphers the Metabolic and Transcriptional Reprogramming in Mice Due to Vespa mandarinia Venom [0.03%]
整合转录组和代谢组解码鬼针草黄毛胡蜂毒液引起的小鼠代谢及转录重编程机制
Jisu Jin,Guangyuan Jiao,Xiaolei Huang et al.
Jisu Jin et al.
Venom-mediated systemic toxicity is not fully understood. This study explored the dose-dependent effects of Vespa mandarinia venom (VMV) on mice via integrated transcriptomic and metabolomic analyses. Subcutaneous VMV injection induced dose...
Co-Exposure to Aflatoxin B1 and Patulin Induces Hepatic Injury in Mice and HepG2 Cells by Activating Oxidative Stress and Apoptosis [0.03%]
黄曲霉毒素B1和果胶素共暴露通过激活氧化应激和凋亡诱导小鼠和HepG2细胞肝损伤
Yaqian Liu,Shimin Lei,Yixuan Peng et al.
Yaqian Liu et al.
Aflatoxin B1 (AFB1) and patulin (PAT) are prevalent foodborne mycotoxins with hepatotoxic potential, but the hepatic effects of combined exposure remain largely unclear. This study investigated the hepatotoxic consequences of co-exposure to...
Harmful Algae in a Changing World: Where Did You Come from and Where Are We Going [0.03%]
多变世界中的有害藻华：你们从哪里来？我们要往何处去？
Katia Comte
Katia Comte
Aquatic environments, whether freshwater, brackish, or marine, are increasingly disrupted, in terms of frequency, extent, geographic distribution, and duration, by the massive, worldwide proliferation of harmful and/or nuisance algae, the s...
Editorial
Toxins. 2026 Apr 23;18(5):196. DOI:10.3390/toxins18050196 2026
Effects of Zearalenone on the Kiss1/GPR54 System and Related Genes Expression in the Hypothalamus and Pituitary Gland of Weaned Gilts [0.03%]
黄曲伏马毒素对断奶仔猪下丘脑和垂体Kiss1/GPR54系统及相关基因表达的影响
Zixue Yuan,Min Zhou,Yue Luan et al.
Zixue Yuan et al.
Zearalenone (ZEA) is a potent estrogenic mycotoxin known to disrupt reproductive functions, but its precise central neuroendocrine mechanisms remain unclear. This study investigated the effects of ZEA on the hypothalamic-pituitary Kiss1/GPR...
Detoxification of Ochratoxin a by Weizmannia coagulans CGMCC 9951: Characterization, Mechanism, and Application in Cornus officinalis Pulp [0.03%]
魏氏乳杆菌CGMCC 9951降解赭曲霉毒素A的特性、机制及其在山茱萸果浆中的应用研究
Cuiping Shao,Yalin Li,Ying Wu et al.
Cuiping Shao et al.
This study investigates the degradation characteristics, pathways, and mechanisms of ochratoxin A (OTA) by Weizmannia coagulans CGMCC 9951 (W. coagulans CGMCC 9951), as well as its detoxification effect on Cornus officinalis pulp through fe...
Thermostable Oxidoreductases CotA and Prx Enable Synergistic and Peroxide-Enhanced Degradation of Aflatoxin B1 [0.03%]
热稳定的氧化还原酶CotA和Prx可协同增强过氧化氢促进的黄曲霉毒素B1降解作用
Xinyue Zhang,Yufan Yang,Yongping Jiang et al.
Xinyue Zhang et al.
Aflatoxin B1 (AFB1) is a highly stable mycotoxin that can persist during conventional food processing and therefore poses a serious risk to food and feed safety. In this study, two enzymes (CotA and Prx) were heterologously expressed in Bac...
Muscle-Specific Dosing of OnabotulinumtoxinA in Post-Stroke Upper-Limb Spasticity: A Descriptive Literature Review [0.03%]
肉毒杆菌毒素A治疗卒中后上肢肌张力障碍的肌肉特异性剂量选择：文献综述式描述性研究
Małgorzata Cisowska-Adamiak,Magdalena Mackiewicz-Milewska,Elżbieta Dorota Miller
Małgorzata Cisowska-Adamiak
Background: Botulinum neurotoxin type A is widely used in the management of post-stroke upper-limb spasticity; however, many studies report total injected doses rather than muscle-specific dosing, limiting clinical applic...
Establishment of Laboratory Bioassay System for Phyllotreta striolata Larvae and Screening of Novel Bt Cry Proteins [0.03%]
striped叶甲幼虫实验室生物测定体系的建立及新型Bt毒蛋白筛选
Leqi Wang,Zhenyi Liu,Ivan M Dubovskiy et al.
Leqi Wang et al.
Phyllotreta striolata is a global pest of cruciferous vegetables, and controlling its soil-dwelling larvae is challenging. The lack of standardized larval bioassay methods hinders the screening of effective biocontrol agents. In this study,...
Homology Analysis of Polistes dominula and Vespula spp. Venoms: A Comparative In Vitro and In Silico Study [0.03%]
基于Polistes dominula和Vespula昆虫毒液的同源性分析：一种体外和分子对接比较研究
María Morales,Alicia Jordá Marín,Bárbara Cases et al.
María Morales et al.
A homologous classification for vespid venoms is missing. This study compared Polistes dominula and Vespula spp. venoms to evaluate their homology level. P. dominula and Vespula spp. extracts, including V. germanica, V. maculifrons, V. pens...
Comparative Study
Toxins. 2026 Apr 18;18(4):190. DOI:10.3390/toxins18040190 2026
Purification and Characterization of His-Tagged Recombinant Bacteroides fragilis Toxin-2 Variants In Vitro and In Vivo [0.03%]
重组His标签的脆弱拟杆菌毒素2蛋白体外和体内的纯化及鉴定
Woo-Seung Kim,Soohyun Lee,Ki-Ju Kwon et al.
Woo-Seung Kim et al.
Bacteroides fragilis is a major commensal bacterium of the human colon. However, enterotoxigenic B. fragilis (ETBF) secretes B. fragilis toxin (BFT), a zinc-dependent metalloprotease that cleaves E-cadherin and promotes chronic inflammation...