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Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
R Varnier,D Pérol,W Jacot et al. R Varnier et al.
Background: Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) have improved the prognosis of hormone receptor (HR)-positive human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC), but their...
S Champiat,K Ouali,A Laparra et al. S Champiat et al.
Background: The conventional drug development pathway in oncology, spanning 10-15 years, has long been slow, costly, and complex, often marked by late-stage failures due to efficacy or safety concerns. ...
H Vanacker,M Brahmi,D Pissaloux et al. H Vanacker et al.
Background: Neurotrophic receptor tyrosine kinase (NTRK) 1/2/3 fusions, though rare, are highly sought in cancer diagnostics due to tyrosine kinase inhibitors' histology-agnostic approval based on significant efficacy acr...
Z Hou,M Lan,Y-X Zhu et al. Z Hou et al.
Background: Pulmonary lymphoepithelioma-like carcinoma (PLELC) is a rare form of squamous lung cancer with clinical features that have conflicting findings from different studies. Meanwhile, the survival time, pattern of ...
A Kyriazoglou,A Zając,C Valverde et al. A Kyriazoglou et al.
Background: Sarcomas comprise a heterogeneous group of malignant tumors of mesenchymal origin where diagnosis plays a crucial role in tailoring disease management and treatment. In this context, there is a lack of data as...
A M Schram,N Takebe,A Chen et al. A M Schram et al.
Background: Loss of PTEN activity is common in solid tumors and promotes cancer growth through activation of the PI3K pathway. PTEN-deficient tumors have increased dependence on PI3Kβ and are sensitive to PI3Kβ inhibiti...
L Miotke,C Norton,Z Rubnitz et al. L Miotke et al.
Background: Alterations in DNA damage repair (DDR) pathway genes can be exploited by cytotoxic chemotherapy regimens that induce DNA damage. Platinum chemotherapy has been shown to be particularly effective in DDR-mutated...
G Rossi,L Barcellini,M Tagliamento et al. G Rossi et al.
Background: Immunotherapy has rapidly changed the treatment of early-stage non-small-cell lung cancer (NSCLC) in recent years. We aimed to summarize available evidence on the use of immunotherapy in neoadjuvant/perioperat...