Superior protection against tuberculosis using heterologous mRNA nanoadjuvant vaccines [0.03%]
基于异源mRNA纳米佐剂的结核病疫苗提供更强保护效力
Bubacarr J B Touray,Alieu K Faburay,Fakry F Mohamed et al.
Bubacarr J B Touray et al.
Tuberculosis (TB) remains a major global health threat, underscoring the need for vaccines that surpass BCG efficacy. We developed QTAP-R, a novel mRNA-lipid nanoparticle (LNP) vaccine encoding Ag85B, Hsp70, and ESAT-6, to enhance immunity ...
Quillaja saponaria fraction QS-18 as an adjuvant for liposomal seasonal influenza vaccines [0.03%]
冬季节流感疫苗用脂质体季节性流感疫苗佐剂QS-18的研究
Qinzhe Li,Zachary Sia,Yuan Luo et al.
Qinzhe Li et al.
Saponin fractions from Quillaja saponaria (QS) are promising vaccine adjuvants. Among these, QS-21 is a component in several FDA-approved vaccines, but its limited quantity may present a manufacturing bottleneck. While the related saponin, ...
Preclinical efficacy of dendritic cells loaded with newly identified HPV11 E6-derived CD8+ T cell epitopes [0.03%]
负载新鉴定的HPV11E6衍生CD8+T细胞表位树突状细胞的抗病毒疗效研究
Laurie Baert,Chao Gu,Agnes Yang et al.
Laurie Baert et al.
Although the low-risk human papillomaviruses (HPVs), including HPV11, are mainly associated with low-grade lesions, they are also implicated in otolaryngologic malignancies and lung carcinomas. Nonetheless, T cell responses to the low-risk ...
HER-2 therapeutic vaccine is not hampered by concurrent HER-2 monoclonal antibody [0.03%]
赫兹2治疗疫苗不受同时进行的赫兹2单克隆抗体影响
Maria Sofia Semprini,Chiara Cappello,Laura Scalambra et al.
Maria Sofia Semprini et al.
ES2B-C001 represents a new generation of vaccines based on virus-like particles (VLP) that display the full extracellular domain of HER-2 and has now entered clinical development. ES2B-C001 elicited strong anti-HER-2 antibody responses that...
Protective immunity against malaria by a nanoparticle CIS43-based junctional vaccine alone or in combination with R21 [0.03%]
纳米颗粒CIS43结合型疟疾疫苗或与R21联合使用以预防疟疾病毒传播的免疫保护作用
Prabhanshu Tripathi,Ja-Hyun Koo,Xuejun Chen et al.
Prabhanshu Tripathi et al.
Repetitive display of the major repeats of the Plasmodium falciparum circumsporozoite protein (PfCSP) is the basis for two WHO-recommended vaccines: RTS,S/AS01 and R21/Matrix-M. Recently, however, the CIS43 monoclonal antibody that preferen...
Influenza mRNA vaccine with engineered panhandle-forming UTRs provides potent, dose-sparing protection against seasonal influenza viruses [0.03%]
具有工程化茎环结构的UTR的流感mRNA疫苗可有效节省剂量地预防季节性流感病毒
Yifan Xu,Xuehua Wan,Mingzhuo Chen et al.
Yifan Xu et al.
Influenza viruses pose a persistent threat to global public health, causing widespread respiratory illness and significant morbidity. Vaccination remains the most effective strategy to reduce the burden of both seasonal and pandemic influen...
Prefusion-stabilized SARS-CoV-2 spike reshapes antigenic hierarchy and antibody targeting against conserved and occluded epitopes [0.03%]
预融合稳定的SARS-CoV-2刺突蛋白重塑了抗原亲和力层级，针对保守及隐蔽表位的抗体靶向作用发生改变
Shintaro Oishi,Ryutaro Kotaki,Hisham M Dokainish et al.
Shintaro Oishi et al.
Receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike contains multiple classes of antibody epitopes that are associated with diverse neutralizing activities. Although both natural infection...
Adjuvant-induced macrophage activation compromises BA71ΔCD2-mediated protection against African swine fever virus [0.03%]
佐剂诱导的巨噬细胞活化损害BA71ΔCD2对抗非洲猪瘟病毒的保护作用
Aida Tort-Miró,Sergio Montaner-Tarbes,David Marín-Moraleda et al.
Aida Tort-Miró et al.
While effective subunit vaccines against African swine fever (ASF) are still under development, live attenuated vaccines (LAVs) remain the only approach capable of inducing robust protective immunity, though biosafety concerns limit their f...
An open repository of COVID-19 vaccine mandate studies with a worked scoping review of quasi-experimental evidence [0.03%]
一个开放的COVID-19疫苗强制研究库以及准实验证据的工作范围审查
Fabio I Martinenghi,Tanka Prashad Ojha,Amy Thomasson et al.
Fabio I Martinenghi et al.
Vaccine mandates were widely implemented against COVID-19, and a large and multidisciplinary literature has emerged as a result, covering fields such as epidemiology, economics, ethics, and law. We compiled an openly available repository of...
Author Correction: Immunisation of koalas against Chlamydia pecorum results in significant protection against chlamydial disease and mortality [0.03%]
作者更正：针对考拉的沙眼衣原体免疫接种显著保护其免受衣原体疾病和死亡的影响
Samuel Phillips,Jon Hanger,Julien Grosmaire et al.
Samuel Phillips et al.
Published Erratum
NPJ vaccines. 2026 Apr 22;11(1):90. DOI:10.1038/s41541-026-01419-7 2026