Advances and future applications of immunocastration techniques: a comprehensive review [0.03%]
免疫去势技术的研究进展与未来应用：全面综述
Mingshuo Ji,Jiaqi Nie,Yue Chen et al.
Mingshuo Ji et al.
Immunocastration uses antigen-antibody interactions to suppress reproductive function without surgery. This review examines vaccines targeting GnRH, zona pellucida (ZP), and sperm antigens, focusing on GnRH vaccine platforms, carriers, adju...
Author Correction: The TAK-003 story: key decisions that shaped development of a tetravalent dengue vaccine [0.03%]
作者更正：TAK-003的研发历程：登革热四价疫苗开发过程中的关键决策
Ian Escudero,Dieter Gniel,Shibadas Biswal et al.
Ian Escudero et al.
Published Erratum
NPJ vaccines. 2026 May 6;11(1):96. DOI:10.1038/s41541-026-01471-3 2026
Monovalent and multivalent OspA mRNA-LNP vaccines elicit functional antibodies and protect against Borrelia burgdorferi in mice [0.03%]
单价和多价OspA mRNA-LNP疫苗可诱导具有功能的抗体并保护小鼠免受伯氏疏螺旋体的侵害
Meredith B Finn,Graham Willsey,Carol Lyn Piazza et al.
Meredith B Finn et al.
Outer surface protein A (OspA) is a ~30 kDa lipoprotein displayed on the surface of Borrelia burgdorferi sensu lato, the etiological agent of Lyme disease. Here we report on the preclinical evaluation of OspA-encoding nucleoside-modified mR...
Oral delivery of Trichinella spiralis antigens by yeast-derived β-glucan particles enhances anti-helminth immunity [0.03%]
酿酒酵母衍生的β-葡聚糖颗粒口服递送旋毛虫抗原可增强抗寄生虫免疫反应
Zhina Liu,Yi Liu,Zijian Dong et al.
Zhina Liu et al.
Intestinal helminth infections including Trichinella spiralis impose a heavy burden globally, yet effective oral vaccines are lacking due to antigen degradation and poor mucosal immunogenicity. This study develops an oral vaccine platform u...
Immunogenicity of PCV13 during Hospitalization soon after infection resolution: Vaccis study [0.03%]
接种肺炎球菌13价结合疫苗(PCV13)后的免疫原性：Vacris研究
Julie Mérindol,Irit Touitou,Coralie Cruzel et al.
Julie Mérindol et al.
Vaccination against Streptococcus pneumoniae in high-risk patients is crucial and hospitalization is a valuable opportunity. Adult patients hospitalized (>48 hours) for various infectious conditions and eligible for 13-valent pneumococcal c...
Searching for immune correlates in Lassa vaccine development - workshop report [0.03%]
拉沙热疫苗研发中寻找免疫相关因素研讨会报告
Trevor Brasel,Polina Brangel,Ifedayo Adetifa et al.
Trevor Brasel et al.
The first workshop dedicated to Lassa virus–specific correlates of protection (CoP) was held in 2024 and was convened by the Coalition for Epidemic Preparedness Innovations (CEPI). Experts from multiple disciplines reviewed existing knowle...
A TRAC-478-adjuvanted recombinant N1 neuraminidase influenza virus vaccine induces balanced and broadly protective immune responses [0.03%]
一种TRAC-478佐剂重组N1神经氨酸酶流感病毒疫苗可诱导平衡且广谱的免疫反应
Irene Hoxie,Kirill Vasilev,Jordan Clark et al.
Irene Hoxie et al.
Licensed influenza vaccines primarily target the variable hemagglutinin protein and provide inadequate cross-protection against mismatched or drifted viral strains. One promising approach to enhance the breadth of protection is to target th...
Lipid nanoparticle-encapsulated DNA vaccine prevented lung consolidation following heterologous influenza A virus challenge in pigs [0.03%]
脂质纳米颗粒包封的DNA疫苗可预防猪异源流感病毒攻击后的肺部实变
The N Nguyen,Danh C Lai,Hung Q Luong et al.
The N Nguyen et al.
The substantial antigenic diversity of Influenza A virus (IAV) presents significant challenges to the development of broadly protective vaccines for swine. Moreover, pigs vaccinated with whole-inactivated virus or hemagglutinin (HA) subunit...
High affinity is insufficient for strong B cell activation by HIV broadly neutralising antibodies [0.03%]
高亲和力不足以通过HIV广谱中和抗体强烈激活B细胞
Chloe Rees-Spear,Olivia Payne,Emma Touizer et al.
Chloe Rees-Spear et al.
HIV broadly neutralizing antibodies (bnAbs) have been widely studied, and inducing a robust broadly neutralizing response remains a goal for many human vaccine studies. Much research focusses on creating higher affinity antigens to target b...
Preexisting IgG forms immune complexes and links local thermal reactogenicity with immunogenicity in influenza vaccination [0.03%]
存在的IgG形成免疫复合物并连接流感疫苗接种的局部热反应性和免疫原性
Julia R Hirsiger,Silke Scarascia,Mike Recher et al.
Julia R Hirsiger et al.
Pre-existing pathogen-specific antibodies shape vaccine outcomes, yet their impact on local reactogenicity and qualitative features of the immune response are not fully defined. In this prospective human cohort receiving seasonal influenza ...