Rural-urban differences in oral typhoid vaccine responses in Uganda: contribution of Schistosoma mansoni [0.03%]
乌干达城乡口腔伤寒疫苗反应差异：血吸虫病的影响
Bridgious Walusimbi,Agnes Natukunda,Rebecca Amongin et al.
Bridgious Walusimbi et al.
Vaccine immunogenicity varies across populations, yet drivers remain unclear. We compared systemic (plasma) and mucosal (coprological) antibody responses to the oral typhoid vaccine Ty21a, quantified by ELISA, among Ugandan adolescents from...
Resurgence of invasive Haemophilus influenzae type b disease in France, 2017-2024: epidemiological, genomic, and immunological insights [0.03%]
法国2017-2024年侵袭性b型流感嗜血杆菌病卷土来：流行病学、基因组和免疫学见解
Nouria Belkacem,Samy Taha,Aude Terrade et al.
Nouria Belkacem et al.
Haemophilus influenzae type b (Hib) conjugate vaccines have markedly reduced global invasive Hib disease. However, surveillance in France has shown a resurgence of Hib infections in children despite >90% vaccination coverage, coinciding wit...
A 25-year landscape of Escherichia coli vaccine development: systematic review of human clinical studies [0.03%]
大肠杆菌疫苗研发25年进展：系统评价人类临床研究论文
Mosayeb Rostamian,Shahla Shahbazi,Roya Chegene Lorestani et al.
Mosayeb Rostamian et al.
Escherichia coli (E. coli), especially enterotoxigenic (ETEC) and extraintestinal pathogenic (ExPEC) strains, remains a leading cause of diarrheal and systemic infections worldwide. Despite decades of extensive research, no licensed E. coli...
A double-blinded, placebo-controlled field trial of an OspA-based oral reservoir targeted vaccine against Borrelia burgdorferi [0.03%]
一项关于口服靶向OspA疫苗对抗伯氏疏螺旋体的双盲、安慰剂对照田野试验
Amy M Schwartz,Ferney Henao-Ceballos,Kathryn Arnold et al.
Amy M Schwartz et al.
Lyme disease, caused by Borrelia burgdorferi and transmitted by Ixodes scapularis ticks, remains a significant vector-borne illness in the United States. Small mammal reservoirs, particularly Peromyscus leucopus, play a critical role in B. ...
Intranasal boosting enhances genital tract T cell immunity following ChAdOx1/MVA hrHPV therapeutic vaccination [0.03%]
鼻内加强可增强ChAdOx1/MVA hrHPV治疗性疫苗接种后的生殖道T细胞免疫反应
Gemma Hancock,Tom Evans,César López-Camacho et al.
Gemma Hancock et al.
High risk human papillomaviruses (hrHPV) infect mucosal epithelia and are the causative agents of cervical cancer. Prophylactic vaccines protect against disease caused by several, but not all hrHPV types. Furthermore, prophylactic vaccines ...
LNP-based delivery of a Toll-like receptor 9 agonist elicits potent adjuvant effects and antitumor immunity [0.03%]
基于LNP的TLR9激动剂递送诱导强烈的佐剂效应和抗肿瘤免疫反应
Yarong Zeng,Jialin Xu,Feng Han et al.
Yarong Zeng et al.
The success of therapeutic cancer vaccines hinges on overcoming the immunosuppressive tumor microenvironment (TME) and activating robust, durable cellular immunity. Here, we engineered a highly translatable vaccine adjuvant delivery system ...
Global patterns of pertussis incidence and vaccination strategies: implications of divergent surveillance data [0.03%]
白喉发病率及疫苗接种策略的全球模式：不同监控数据的差异导致的涵义
Kangguo Li,Yulun Xie,Jiadong Wu et al.
Kangguo Li et al.
Pertussis remains a global threat for infants, and recent increases in notifications have renewed interest in optimising vaccination strategies and improving vaccines. At the biological level, the rationale for maternal pertussis immunizati...
A BcfA-containing intranasal vaccine generated TH17 immunity and reduced B. bronchiseptica colonization and disease in mice [0.03%]
一种含BcfA的鼻内疫苗能够增强小鼠TH17免疫并减少副猪嗜血杆菌的定植和致病性
Alexa R Aubrey,Komal K Patel,Jesse M Hall et al.
Alexa R Aubrey et al.
Bordetella bronchiseptica (Bb) is a significant etiologic agent of respiratory disease in farm and companion animals. Current vaccines provide short-lived protection against disease, but do not elicit mucosal immunity that is critical for s...
A comparison of two- and three-dose MVA-BN mpox vaccination series on anti-monkeypox virus immunity [0.03%]
两种和三种MVA-BN(mpox)疫苗对抗猴痘病毒免疫力的比较研究
Aaron L Oom,Kesi K Wilson,Stephanie Rettig et al.
Aaron L Oom et al.
The 2022 global outbreak of clade IIb mpox represented a turning point in public health's handling of poxviruses. The primary vaccine available for the prevention of mpox is modified vaccinia Ankara from Bavarian-Nordic (MVA-BN). We previou...
Maturation-deficient chikungunya virus elicits protective immune responses in a murine challenge model [0.03%]
成熟缺陷的 Chicungunya病毒可以在小鼠攻毒模型中引发保护性免疫反应
Danillo Lucas Alves Esposito,Jhefferson Barbosa Guimarães,Benedito Antonio Lopes da Fonseca et al.
Danillo Lucas Alves Esposito et al.
Maturation of chikungunya virus (CHIKV) particles is dependent on cleavage of the precursor glycoprotein p62 into the proteins E3 and E2 by the cellular protease furin. Here, we produced immature CHIKV particles by infecting furin-deficient...