Trends in funding for coronavirus vaccine research and development: implications for preparedness against future coronavirus threats [0.03%]
冠状病毒疫苗研发的融资趋势及其对防范未来冠状病毒威胁的意义
Derek Fleming,Emily Smith,Julie Ostrowsky et al.
Derek Fleming et al.
The COVID-19 pandemic triggered unprecedented investment in coronavirus vaccine R&D, but the long-term trajectory of this funding remains unclear. We mapped coronavirus vaccine grant support from 2020 through 2025, and found an early surge ...
Seasonal influenza mRNA vaccine induces stronger innate and comparable or better adaptive responses than licensed inactivated vaccines [0.03%]
季节性流感mRNA疫苗诱导更强的先天性和相当的或更好的适应性免疫响应相较于批准的灭活疫苗
Erick Bermúdez-Méndez,Klara Lenart,Rodrigo Arcoverde Cerveira et al.
Erick Bermúdez-Méndez et al.
Seasonal vaccination is the most important strategy for mitigating the large disease burden caused by influenza virus. Licensed inactivated influenza virus vaccines rely on slow, egg-based production, underscoring the need for faster, more ...
Heterologous vaccination with a next-generation vaccinia virus and Ad26 induces Ebola-specific immunity in macaques [0.03%]
一种新一代痘病毒和Ad26异源疫苗诱导食蟹猴产生埃博拉特异性免疫反应
Aneesh Vijayan,Tamara Cooper,Marijn van der Neut Kolfschoten et al.
Aneesh Vijayan et al.
Different ways of combining virus vector-based vaccines can impact the effectiveness of immune responses against specific antigens. In this study, we explored the effects of different immunization schedules on immune responses elicited by v...
The role of naturally occurring and vaccine-induced Ad26 neutralizing antibodies in immunogenicity of Ad26-based vaccines [0.03%]
既往感染和疫苗接种诱导的腺病毒26型中和抗体对以腺病毒26载体为基础的疫苗免疫原性的影响作用
Mariska G M van Rosmalen,Joris Menten,Daniel J Stieh et al.
Mariska G M van Rosmalen et al.
Adenovirus 26 (Ad26) is frequently used as a vaccine vector targeting infectious diseases. Neutralizing antibodies (NAbs) induced by natural infection or immunization against some viral vaccine vectors may impact vaccine-induced immunogenic...
Long-term cross-variant Fc-mediated immune responses against SARS-CoV-2 induced by a heterologous adenoviral/inactivated virus prime-boost vaccination strategy [0.03%]
异源型腺病毒/灭活疫苗序贯接种诱导长效交叉谱系的SARS-CoV-2体液免疫应答
Doyoung Kim,Jung Hyuk Lee,Junhyeon Lee et al.
Doyoung Kim et al.
Limited vaccine availability and logistical barriers during the COVID-19 pandemic have hindered homologous boosting in resource-limited regions. Therefore, heterologous prime-boost regimens have gained attention as versatile and practical a...
Recent advances in Epstein-Barr virus vaccines development from mechanistic exploration to clinical translation [0.03%]
从机制探索到临床转化：Epstein-Barr病毒疫苗开发的最新进展
Liwei Hong,Juju Zhou,Junjuan Tan et al.
Liwei Hong et al.
Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus linked to malignancies and autoimmune diseases. No licensed vaccines are currently available. Recent advances in EBV biology have enabled rational antigen selection and accelerated de...
Vaccination in individuals with Down syndrome: immune vulnerability, safety, efficacy and opportunities [0.03%]
唐氏综合症个体的疫苗接种：免疫易感性、安全性、有效性和机遇
Bernard Khor,Noemi A Spinazzi,Lina R Patel et al.
Bernard Khor et al.
Although individuals with Down syndrome (DS) remain highly vulnerable to severe infections, vaccination remains underutilized. Here we review, specific to people with DS, the safety and efficacy of vaccination, drivers of susceptibility to ...
Vaccine communication: a critical review of foundations, challenges, and future directions [0.03%]
疫苗沟通：基础、挑战与未来方向批判性回顾
Xiaoli Nan
Xiaoli Nan
Vaccination remains one of the most effective public health interventions, yet sustaining uptake is increasingly challenged by complex informational and political environments. This review provides a targeted synthesis of existing evidence ...
β-Glucan chitosan particle provides cross-protection against multi-drug-resistant Candida auris [0.03%]
β-葡聚糖壳聚糖颗粒可提供对多重耐药耳念珠菌的交叉保护作用
Shakti Singh,Ashley Barbarino,Eman G Youssef et al.
Shakti Singh et al.
Multidrug-resistant fungi, Candida auris, persist in the healthcare environment and colonize human skin and medical devices, causing life-threatening infections with mortality rates approaching ~60% in immunocompromised patients. Because so...
Developing a durable, memory-driven, CspZ-targeting Lyme disease vaccine by rationale adjuvant selection [0.03%]
通过合理选择佐剂开发一种持久的、基于记忆的CspZ靶向型Lyme病疫苗
Miranda McCarty,Sergio A Hernández,Jill Malfetano et al.
Miranda McCarty et al.
Rational adjuvant selection is a systematic approach based on adjuvant-mediated immunomodulation to identify safe vaccine regimens that enhance protective immunity. Transmitted through ticks and caused by the bacterium Borrelia burgdorferi ...