Development of a multi-epitope mRNA vaccine targeting tumor-associated antigens for esophageal squamous cell carcinoma [0.03%]
一种针对食管鳞状细胞癌相关抗原的多表位mRNA肿瘤疫苗的研发
Henghui Zhang,Hao Liang,Tingting Dai et al.
Henghui Zhang et al.
Esophageal squamous cell carcinoma (ESCC) has limited treatment options post-immune checkpoint inhibitor (ICI) resistance. We developed IPM514, a universal multi-epitope mRNA lipid nanoparticle (LNP) vaccine targeting tumor-associated antig...
Evaluating large language models on multilingual vaccine knowledge: a benchmark study [0.03%]
多语言疫苗知识的大型语言模型评估：一项基准研究
Siyuan Chen,Lily Wass,Zhengdong Wu et al.
Siyuan Chen et al.
Large language models (LLMs) are increasingly used by clinicians and the public for vaccine information, yet their factual accuracy across languages and vaccine domains remains insufficiently characterized. We evaluated 13 LLMs using VaxEva...
Pre-clinical efficacy of a candidate outer membrane vesicle gonococcal vaccine in comparison with 4CMenB [0.03%]
候选的淋球菌外膜囊泡疫苗的临床前疗效与4CMenB的比较
Paula Freixeiro,Lisa A Lewis,Leonor Sánchez-Busó et al.
Paula Freixeiro et al.
Neisseria gonorrhoeae causes 82 million global cases of gonorrhoea annually. Multidrug-resistant gonococci threaten to make gonorrhoea untreatable. Meningococcal vaccines MeNZB and 4CMenB (Bexsero), containing Neisseria meningitidis group B...
Response to vaccination and immune status after intrauterine exposure to immunomodulating drugs for maternal IBD [0.03%]
免疫调节药物诱发的宫内暴露后儿童接种疫苗的抗体应答及免疫力研究
Jantien W Wieringa,Mirjam J Esser,Matthijs D Kruizinga et al.
Jantien W Wieringa et al.
Guidelines on inflammatory bowel disease (IBD) recommend continuing immunomodulating drugs during pregnancy, but their effects on the infant immune system remain uncertain. In this observational study, infants exposed to maternal IBD medica...
Genetically diverse CC and DO mouse models enable comprehensive assessments of novel tuberculosis vaccines [0.03%]
遗传多样的CC和DO小鼠模型能够对新型结核疫苗进行综合评估
Rocky Lai,Sherry L Kurtz,Victoria Gould et al.
Rocky Lai et al.
Development of a new vaccine for tuberculosis (TB) to replace the BCG vaccine has been hampered by the lack of a preclinical vaccine model that accurately reflects the genetic heterogeneity of the human population. We previously tested both...
Population-level impact of quadrivalent HPV vaccination in Brazil: a repeated cross-sectional study [0.03%]
巴西四价人乳头瘤病毒疫苗的群体水平影响：一项重复横断面研究
Eliana Marcia Wendland,Rafael Steffens Martins,Natália Luiza Kops et al.
Eliana Marcia Wendland et al.
Human papillomavirus vaccination is central to cervical cancer elimination, yet population-level evidence from middle-income countries remains limited. We evaluated the impact of quadrivalent HPV vaccination in Brazil using data from two re...
Changchun Chen,Cheng Zhang,Shanyuan Zhu et al.
Changchun Chen et al.
Chitosan nanoparticles are emerging as versatile vaccine carriers that enhance antigen stability, improve mucosal delivery, and strengthen immune activation. This review synthesizes advances in their biological functions, chemical engineeri...
Schistosomiasis vaccine SchistoShield® induces functional immune memory responses in US and African populations [0.03%]
一种血吸虫病疫苗SchistoShield®能够诱导美国和非洲人群产生功能性免疫记忆反应
Mumtaz Y Balkhi,Aravindan Kalyanasundaram,Aryandra Arya et al.
Mumtaz Y Balkhi et al.
Helminth parasites of the genus Schistosoma cause 290,000 deaths annually, mostly in tropical and subtropical regions. An estimated 250 million people are currently chronically infected with Schistosoma parasites, imposing a risk of new and...
Author Correction: Production of an immunogenic trivalent poliovirus virus-like particle vaccine candidate in yeast using controlled fermentation [0.03%]
作者更正：使用可控发酵在酵母中生产免疫原性三价脊髓灰质炎病毒样颗粒疫苗候选者
Lee Sherry,Keith Grehan,Mohammad W Bahar et al.
Lee Sherry et al.
Published Erratum
NPJ vaccines. 2026 May 29;11(1):110. DOI:10.1038/s41541-026-01470-4 2026
MVA-BN monkeypox vaccine safety in a clinical trial in the Democratic Republic of the Congo [0.03%]
刚果民主共和国临床试验中的MVA-BN猴痘疫苗安全性研究
Nsengi Ntamabyaliro,Tyler Bonnett,Gail Potter et al.
Nsengi Ntamabyaliro et al.
The MVA-BN vaccine is considered safe and effective and has been widely deployed to prevent monkeypox. However, safety and tolerability data from endemic areas are limited. We performed a single-arm clinical trial of the safety of the MVA-B...