EGFR mimotope alleviates renal fibrosis by promoting EGFR/RPL6/PCBP2 ternary complex formation [0.03%]
表皮生长因子受体拟态肽通过促进表皮生长因子受体/核糖体蛋白L6/多聚胞苷酸结合蛋白2三元复合物的形成从而缓解肾纤维化
Qing Wu,Yu Chen,Di Zhao et al.
Qing Wu et al.
Epidermal growth factor receptor (EGFR) signalling plays a crucial role in renal fibrosis. We previously demonstrated that EGFR mimotope vaccination could alleviate renal fibrosis by restoring major histocompatibility complex class IB (MHC-...
Epitope-selective vaccine designs to elicit protective antibodies against the Plasmodium falciparum circumsporozoite protein [0.03%]
针对恶性疟原虫环子孢子蛋白诱导保护性抗体的抗原位点选择性疫苗设计
Mohammad Naghizadeh,Yevel Flores-Garcia,Reem Moskovitz et al.
Mohammad Naghizadeh et al.
P. falciparum (Pf) malaria is a major cause of morbidity and mortality in sub-Saharan Africa. Recently introduced malaria vaccines, RTS,S/AS01 and R21/Matrix-M, are effective in preventing infection, but their efficacy declines over time. T...
Oral contraceptive usage among healthcare workers and its impact on COVID-19 booster vaccination immunogenicity [0.03%]
医疗工作者口服避孕药使用情况及其对COVID-19疫苗加强剂免疫原性的影响
Isabell Wagenhäuser,Julia Reusch,Juliane Mees et al.
Isabell Wagenhäuser et al.
Oral contraceptives (OCs) can substantially modulate immune responses; however, their impact on vaccine immunogenicity remains poorly understood. This study investigated OC use patterns and their determinants among healthcare workers (HCWs)...
Mapping SARS-CoV-2 immunity after an XBB.1.5 booster by antigenic cartography of merged human and hamster sera [0.03%]
通过合并的人类和仓鼠血清的抗原图谱绘制，研究XBB.1.5加强针后的SARS-CoV-2免疫力分布情况
Marta Bermejo-Jambrina,Antonia Netzl,Ludwig Knabl et al.
Marta Bermejo-Jambrina et al.
The ongoing evolution of SARS-CoV-2, particularly the emergence and rapid spread of new immune-evasive variants, continues to challenge the durability of vaccine-induced protection. Understanding how repeated variant exposures shape neutral...
Safety and immunogenicity of concomitant quadrivalent meningococcus ACYW-TT and meningococcus group B vaccines [0.03%]
ACYW-TT脑膜炎球菌四价结合疫苗和B型脑膜炎球菌疫苗联合免疫的安全性和免疫原性
Monica A McArthur,Adam Finn,Lawrence Barnes et al.
Monica A McArthur et al.
Infants are vulnerable to meningococcal disease. In this open-label phase III study (NCT03632720; registered 13/8/2018), infants were randomised to quadrivalent ACWY conjugated vaccine, MenACYW-TT, at 3 and 12-13 months and four-component m...
COVID-19 vaccination induces cross-neutralisation of sarbecoviruses related to SARS-CoV-2 [0.03%]
针对SARS-CoV-2的相关sarbecovirus的新冠疫苗交叉中和反应
Grace E West,Rebecca B Morse,Benjamin L Sievers et al.
Grace E West et al.
The combined threats of future sarbecovirus zoonosis and continually emerging SARS-CoV-2 VOCs highlight the need to assess the breadth of existing SARS-CoV-2 vaccine-mediated protection. Here, we investigate a cohort of older individuals wh...
Emilie C Rijnink,Muriel Aguilar-Bretones,Rory D de Vries et al.
Emilie C Rijnink et al.
Yellow fever (YF) vaccination is generally contraindicated in individuals with thymic disorders because of the risk of YF vaccine-associated viscerotropic disease (YEL‑AVD). As YF transmission expands and global travel increases, protectio...
Next-generation mRNA vaccines: strategies to overcome stability challenges [0.03%]
下一代mRNA疫苗：克服稳定性的挑战策略
Abdullah Algaissi,Sivakumar S Moni
Abdullah Algaissi
Messenger RNA (mRNA) vaccines represent a paradigm shift in rapid vaccine development and pandemic preparedness, enabling unprecedented speed in antigen design and scalable, cell-free manufacturing. Despite proven clinical efficacy, widespr...
BCG enables protection against malaria through adjuvanting an adenovirus-vectored vaccine [0.03%]
巴斯德氏菌作为佐剂增强腺病毒载体疟疾疫苗的保护效力
Sören Reinke,Marta Ulaszewska,Qi Su et al.
Sören Reinke et al.
BCG vaccination against TB may also reduce malaria incidence through non-specific innate immune activation. We investigated whether giving BCG alongside an adenoviral-vectored malaria vaccine improves protection against malaria in mice. Co-...
Therapeutic DC vaccination against the vascular antigen DLK1 effectively treats primary triple-negative breast cancer and prevents metastasis [0.03%]
针对血管抗原DLK1的治疗性DC疫苗有效治疗三阴性乳腺癌并预防转移
Elizabeth A Daugherity,Caryn Lawrence,Izuchukwu F Okpalanwaka et al.
Elizabeth A Daugherity et al.
Despite improved treatment options for triple-negative breast cancer (TNBC) patients including immune checkpoint blockade (ICB) alongside chemotherapy, clinical prognosis for these individuals remains poor with regard to disease recurrence ...