Hemagglutination-inhibition and microneutralization antibody titers as mediators of protection for cell-based and recombinant influenza vaccines [0.03%]
基于细胞的和重组的流感疫苗中血凝抑制和微中和抗体滴度的保护作用分析
Shuyi Zhong,Wey Wen Lim,Faith Ho et al.
Shuyi Zhong et al.
The proportion of relative influenza vaccine efficacy (rVE) mediated by post-vaccination hemagglutination inhibition (HAI) and microneutralization (MN) antibody titers has not been evaluated. We compared rVE by influenza vaccine type and HA...
Post-exposure vaccination with an adjuvanted protein subunit vaccine, but not BCG, protects mice and guinea pigs against M. tuberculosis [0.03%]
一种佐剂蛋白亚单位疫苗在暴露后的免疫能够保护小鼠和 Guinea Pig不受结核杆菌的感染，而卡介苗则不能
Joshua S Woodworth,Claus Aagaard,Francisco J Salguero et al.
Joshua S Woodworth et al.
Tuberculosis (TB) remains a global health priority and vaccines targeting populations with prior Mycobacterium tuberculosis (Mtb) exposure are predicted to most rapidly impact epidemic control. Paradoxically, while efficacy trials are prima...
A next-generation human lymphatic filariasis vaccine candidate, rBmHAXT, for clinical development [0.03%]
一种下一代的人类淋巴丝虫病疫苗候选药物rBmHAXT即将进入临床开发阶段
Nithila Saravanan,Sean A Gray,Jennifer Davis et al.
Nithila Saravanan et al.
This study was conducted to develop a robust, scalable manufacturing process for the candidate vaccine rBmHAXT for human lymphatic filariasis (LF). During scale-up production, rBmHAXT showed significant antigen aggregation leading to a loss...
Preclinical immunogenicity of the LP.8.1-adapted BNT162b2 COVID-19 vaccine [0.03%]
LP.8.1适应的BNT162b2新冠疫苗的免疫原性研究
Chaitanya Kurhade,Wei Chen,Weiqiang Li et al.
Chaitanya Kurhade et al.
SARS-CoV-2 evolution toward antigenically distinct lineages drives escape from host immunity. JN.1 lineage derivatives have recently dominated the global epidemiologic landscape. In preclinical models, an LP.8.1-adapted BNT162b2 vaccine eli...
The immunogenicity of pneumococcal conjugate vaccinations in patients with asplenia and hyposplenia: a systematic review [0.03%]
无脾和低脾患者中肺炎球菌结合疫苗免疫原性的系统性回顾
B van Put,G E Loe-Sack-Sioe,L G Visser et al.
B van Put et al.
Pneumococcal conjugate vaccines (PCVs) are important preventive tools against invasive pneumococcal disease (IPD) in asplenic patients. This systematic review assesses current data and knowledge gaps on the immunogenicity of PCVs in aspleni...
Real-world effectiveness and impact of the 4CMenB vaccine against serogroup B invasive meningococcal disease: a systematic review and meta-analysis [0.03%]
用于预防B族脑膜炎奈瑟菌侵袭性疾病的4CMenB疫苗的真实世界效果和影响：系统评价和荟萃分析
Pavo Marijic,Katarzyna Jamróz-Dolińska,Wojciech Margas et al.
Pavo Marijic et al.
4CMenB vaccine is authorized for protection against serogroup B invasive meningococcal disease (IMD). This study synthesized real-world evidence (RWE) data on effectiveness and impact of 4CMenB vaccine. A systematic search identified RWE on...
Muscle macrophage regenerative response after squalene-adjuvanted influenza vaccination is associated with type II-skewed response and is reduced with age [0.03%]
角鲨烯佐剂的流感疫苗接种诱导的肌肉巨噬细胞再生型免疫反应具有2型特征且随年龄增长而降低
Moataz Noureddine,Lauren A Chang,Farah El Ayache et al.
Moataz Noureddine et al.
Squalene-based adjuvants like MF59 and AddaVax induce transient muscle injury, but their downstream mechanisms remain unclear. We show that intramuscular injection of a quadrivalent inactivated influenza vaccine (QIV) with AddaVax triggers ...
Modeling time-varying efficacy of RTS,S/AS01 malaria vaccine across trial settings [0.03%]
在不同试验环境下模拟RTS,S/AS01疟疾疫苗效力的动态变化
Ziwei Zhao,Paul Milligan,Yin Bun Cheung
Ziwei Zhao
Correctly evaluating how vaccine efficacy (VE) changes over time is important for understanding long-term protection and guiding vaccination strategies. Using the 18-month pre-booster data from the multi-center RTS,S/AS01 malaria vaccine tr...
EGFR mimotope alleviates renal fibrosis by promoting EGFR/RPL6/PCBP2 ternary complex formation [0.03%]
表皮生长因子受体拟态肽通过促进表皮生长因子受体/核糖体蛋白L6/多聚胞苷酸结合蛋白2三元复合物的形成从而缓解肾纤维化
Qing Wu,Yu Chen,Di Zhao et al.
Qing Wu et al.
Epidermal growth factor receptor (EGFR) signalling plays a crucial role in renal fibrosis. We previously demonstrated that EGFR mimotope vaccination could alleviate renal fibrosis by restoring major histocompatibility complex class IB (MHC-...
Epitope-selective vaccine designs to elicit protective antibodies against the Plasmodium falciparum circumsporozoite protein [0.03%]
针对恶性疟原虫环子孢子蛋白诱导保护性抗体的抗原位点选择性疫苗设计
Mohammad Naghizadeh,Yevel Flores-Garcia,Reem Moskovitz et al.
Mohammad Naghizadeh et al.
P. falciparum (Pf) malaria is a major cause of morbidity and mortality in sub-Saharan Africa. Recently introduced malaria vaccines, RTS,S/AS01 and R21/Matrix-M, are effective in preventing infection, but their efficacy declines over time. T...