Targeting the Zika virus envelope domains I and III as a recombinant vaccine protects mice from lethal challenge [0.03%]
以寨卡病毒包膜I型和III型域作为重组疫苗可保护小鼠免受致命攻击
Vincent Dussupt,Jaime L Jensen,Angélica Peña Rosado et al.
Vincent Dussupt et al.
Zika virus (ZIKV) vaccine candidates developed through Phase I clinical trials are based on the full-length envelope glycoprotein (E), which presents both desirable and undesirable antigenic determinants. Among the latter, the conserved fus...
An ESAT-6-convergent prime-boost vaccination combining recombinant BCG expressing Mycobacterium marinum ESX-1 and ESAT-6/GLA-SE improves TB protection [0.03%]
一种结合了表达海洋分枝杆菌ESX-1和ESAT-6/GLA-SE的重组卡介苗（BCG）的收敛性“Prime-Boost”疫苗可增强抗结核保护力
Kee Woong Kwon,Hongmin Kim,Hagyu Kim et al.
Kee Woong Kwon et al.
Although Bacille Calmette-Guérin (BCG) protects children against disseminated tuberculosis (TB), its limited efficacy against adult pulmonary TB underscores the need for improved vaccination strategies. We previously developed a recombinan...
Influenza vaccine-specific CD4+ T cell responses are impaired in older adults [0.03%]
老年人群中的流感病毒特异性CD4+t细胞应答减弱
Pauline Saint-Charles,Magdalena Hagen,Gaëlle Autaa et al.
Pauline Saint-Charles et al.
Immune defenses decline with age, increasing susceptibility to influenza. Vaccination remains the most effective strategy to prevent severe disease and death, but its efficacy is reduced in older adults, particularly against influenza A(H3N...
USTAT: Unified Sequential Template Amplification and Transcription-a fully synthetic mRNA manufacturing platform [0.03%]
USTAT：统一的顺序模板扩增与转录-一种完全合成的mRNA制造平台
Swap Ghosh,Carrie L Simms,Sage D Rohrer et al.
Swap Ghosh et al.
mRNA vaccines have emerged as a transformative modality for infectious disease prevention. In response to the emergence of SARS-CoV-2, large-scale in vitro transcription (IVT) of mRNA vaccines was developed. Large-scale IVT currently relies...
Noncanonical amino acids enable plug and play vaccine platform in the ALiCE cell free system [0.03%]
非天然氨基酸使ALiCE无细胞系统具备 Plug-and-play 疫苗平台功能
Jorge Armero-Gimenez,Janis Schleusner,Ruud H P Wilbers et al.
Jorge Armero-Gimenez et al.
Non-canonical amino acids (ncaas) are increasingly used in vaccinology to improve vaccine adaptability and immunogenicity. Cell-free protein synthesis (CFPS) offers a promising route for site-specific ncaa incorporation, but conventional pr...
MF59-adjuvanted A/Astrakhan influenza vaccine induces cross-neutralizing H5N1 antibodies in ferrets against circulating clade 2.3.4.4b viruses [0.03%]
MF59佐剂A/阿斯特拉汗流感疫苗可诱导雪貂中针对2.3.4.4b分支毒株的交叉中和H5N1抗体
Karen Segovia,Raveen Rathnasinghe,Christopher Patton et al.
Karen Segovia et al.
The continued global spread of highly pathogenic avian influenza A(H5N1) viruses, particularly clade 2.3.4.4b, has increased zoonotic spillover risk and underscored the urgency of pandemic preparedness. Human vaccination is a key strategy f...
Mycobacterium tuberculosis bacteriology and immunity necessitate a multi-pronged immune strategy for vaccination [0.03%]
结核分枝杆菌的细菌学和免疫学要求疫苗接种采用多管齐下的免疫策略
Jan T Poolman
Jan T Poolman
Mycobacterium tuberculosis (Mtb) continues to kill more individuals each year than any other individual pathogen. Advances in bacteriology and immunology signify that Mtb vaccines need to induce responses from multiple components of the imm...
Stephanie Longet,Stephane Paul
Stephanie Longet
The COVID-19 pandemic has accelerated the development of intranasal and inhaled COVID-19. vaccines. Four vector-based and one adjuvanted protein-based vaccines have been licenced. They have been shown to be safe. However, their ability to i...
Cattle antibodies identify a cross-serotype broadly neutralising foot-and-mouth disease virus epitope [0.03%]
牛抗体识别一种交叉血清型的广谱中和的口蹄疫病毒表位
Marie Bonnet-Di Placido,Helen M E Duyvesteyn,Angela W Steyn et al.
Marie Bonnet-Di Placido et al.
Foot-and-mouth disease virus (FMDV) causes a devastating disease that threatens global food security. Vaccination is hindered by antigenic diversity across serotypes. To identify cross-serotype neutralising epitopes, we isolated 24 FMDV-spe...
IL-1 delineates squalene-based adjuvant efficacy and reactogenicity in a cell-type-specific manner [0.03%]
细胞特异性地确定角鲨烯佐剂的效果和不良反应_IL-1的作用
Yuya Yoshioka,Anri Nishinaka-Yoshioka,Kouji Kobiyama et al.
Yuya Yoshioka et al.
Squalene-based adjuvants are widely utilized in various vaccines because of their effectiveness in enhancing immune responses. Among these, A-910823 and AS03 are recognized squalene-based adjuvants containing α-tocopherol. Although α-toco...