Xiangsheng Liu,Jinhong Jiang,Ying Ji et al.
Xiangsheng Liu et al.
Many solid tumor types, such as pancreatic cancer, have a generally poor prognosis, in part because the delivery of therapeutic regimen is prohibited by pathological abnormalities that block access to tumor vasculature, leading to poor bioa...
Optimizing self-consistent field theory block copolymer models with X-ray metrology [0.03%]
基于X射线计量学优化嵌段共聚物模型的自洽场理论
Adam F Hannon,Daniel F Sunday,Alec Bowen et al.
Adam F Hannon et al.
A block copolymer self-consistent field theory (SCFT) model is used for direct analysis of experimental X-ray scattering data obtained from thin films of polystyrene-b-poly(methyl methacrylate) (PS-b-PMMA) made from directed self-assembly. ...
Modulating the Catalytic Activity of Enzyme-like Nanoparticles Through their Surface Functionalization [0.03%]
通过表面功能化调节类似酶的纳米颗粒的催化活性
Roberto Cao-Milán,Luke D He,Spencer Shorkey et al.
Roberto Cao-Milán et al.
The inclusion of transition metal catalysts into nanoparticle scaffolds permits the creation of catalytic nanosystems (nanozymes) able to imitate the behaviour of natural enzymes. Here we report the fabrication of a family of nanozymes comp...
Engineering affinity agents for the detection of hemi-methylated CpG sites in DNA [0.03%]
用于检测DNA中半甲基化CpG位点的亲和试剂的工程学研究
B E Tarn,K-J Sung,H D Sikes
B E Tarn
Wild-type methyl-CpG-binding domain (MBD) proteins specifically bind symmetrically methylated DNA sequences, and assays have been developed that use these proteins for profiling DNA methylation. Here, we use directed evolution in the yeast ...
Activity-based assessment of an engineered hyperthermophilic protein as a capture agent in paper-based diagnostic tests [0.03%]
一种工程化蛋白的活性评价及其在纸基诊断测试中的应用研究
E A Miller,M W Traxlmayr,J Shen et al.
E A Miller et al.
Antibodies have traditionally served as the affinity reagents of choice in point-of-care diagnostic biosensors. However, this class of proteins is not ideally suited for this use, being poorly characterized and prone to thermal denaturation...
Insights from molecular dynamics simulations for computational protein design [0.03%]
计算蛋白质设计的分子动力学模拟见解
Matthew Carter Childers,Valerie Daggett
Matthew Carter Childers
A grand challenge in the field of structural biology is to design and engineer proteins that exhibit targeted functions. Although much success on this front has been achieved, design success rates remain low, an ever-present reminder of our...
Microparticulate/Nanoparticulate Powders of a Novel Nrf2 Activator and an Aerosol Performance Enhancer for Pulmonary Delivery Targeting the Lung Nrf2/Keap-1 Pathway [0.03%]
一种新型Nrf2激活剂和吸入性能增强剂的微粒/纳米粉体，用于针对肺部Nrf2/Keap-1途径的肺递送
Priya Muralidharan,Don Hayes Jr,Stephen M Black et al.
Priya Muralidharan et al.
This systematic and comprehensive study reports for the first time on the successful rational design of advanced inhalable therapeutic dry powders containing dimethyl fumarate, a first-in-class Nrf2 activator drug to treat pulmonary inflamm...