Zr-MOFs for CF4/CH4, CH4/H2, and CH4/N2 separation: towards the goal of discovering stable and effective adsorbents [0.03%]
用于CF4/CH4、CH4/H2和CH4/N2分离的锆基MOFs：寻找稳定有效的吸附剂的研究
Hakan Demir,Seda Keskin
Hakan Demir
Zirconium metal-organic frameworks (MOFs) can be promising adsorbents for various applications as they are highly stable in different chemical environments. In this work, a collection of Zr-MOFs comprised of more than 100 materials is scree...
Placement of Tyrosine Residues as a Design Element for Tuning the Phase Transition of Elastin-peptide-containing Conjugates: Experiments and Simulations [0.03%]
酪氨酸残基在弹性肽共轭物相变调节设计中的定位：实验与模拟研究
Phillip A Taylor,Haofu Huang,Kristi L Kiick et al.
Phillip A Taylor et al.
Elastin-like polypeptides (ELP) have been widely used in the biomaterials community due to their controllable, thermoresponsive properties and biocompatibility. Motivated by our previous work on the effect of tryptophan (W) substitutions on...
Impact of Glutamate Carboxylation in the Adsorption of the α-1 Domain of Osteocalcin to Hydroxyapatite and Titania [0.03%]
谷氨酸羧基化对骨钙素α-1区与羟基磷灰石和二氧化钛吸附影响的理论研究
Sarah Alamdari,Jim Pfaendtner
Sarah Alamdari
One proposed mechanism of implant fouling is attributed to the nonspecific adsorption of non-collagenous bone matrix proteins (NCPs) onto a newly implanted interface. With the goal of capturing the fundamental mechanistic and thermodynamic ...
Reporter system architecture affects measurements of noncanonical amino acid incorporation efficiency and fidelity [0.03%]
报告系统架构影响非规范氨基酸掺入效率和保真性的测量
K A Potts,J T Stieglitz,M Lei et al.
K A Potts et al.
The ability to genetically encode noncanonical amino acids (ncAAs) within proteins supports a growing number of applications ranging from fundamental biological studies to enhancing the properties of biological therapeutics. Currently, our ...
Designing Molecular Building Blocks for the Self-assembly of Complex Porous Networks [0.03%]
用于复杂多孔网络分子自组装的构建块的设计
T Ann Maula,Harold W Hatch,Vincent K Shen et al.
T Ann Maula et al.
The creation of molecular or colloidal building blocks which can self-assemble into complex, ordered porous structures has been long sought-after, and so are the guiding principles behind this creation. The pursuit of this goal has led to t...
Maria Sánchez-Purrà,Biel Roig-Solvas,Alice Versiani et al.
Maria Sánchez-Purrà et al.
Surface enhanced Raman spectroscopy (SERS) has been attractive for enhancing the sensitivity of lateral flow immunoassays (LFA). A format that has enabled specific detection of biomarkers is to use Raman reporter molecules linked to gold na...
Jonathan Ozik,Nicholson Collier,Randy Heiland et al.
Jonathan Ozik et al.
We present an integrated framework for enabling dynamic exploration of design spaces for cancer immunotherapies with detailed dynamical simulation models on high-performance computing resources. Our framework combines PhysiCell, an open sou...
Evaluation of affibody charge modification identified by synthetic consensus design in molecular PET imaging of epidermal growth factor receptor [0.03%]
利用合成共识设计评价修饰亲和体电荷进行表皮生长因子受体的分子PET显像
Brett A Case,Max A Kruziki,Lawrence A Stern et al.
Brett A Case et al.
Tumor overexpression of epidermal growth factor receptor (EGFR) correlates to therapeutic response in select patient populations. Thus, molecular positron emission tomography (PET) imaging of EGFR could stratify responders versus non-respon...
Systematic Mutagenesis of Oncocin Reveals Enhanced Activity and Insights into the Mechanisms of Antimicrobial Activity [0.03%]
系统诱变筛选抗菌肽Oncocin的突变体可增强其活性并揭示抗菌作用机制
Pin-Kuang Lai,Kathryn Geldart,Seth Ritter et al.
Pin-Kuang Lai et al.
Oncocin is a proline-rich antimicrobial peptide that inhibits protein synthesis by binding to the bacterial ribosome. In this work, the antimicrobial activity of oncocin was improved by systematic peptide mutagenesis and activity evaluation...
Nitro Sulfonyl Fluorides are a new pharmacophore for the development of antibiotics [0.03%]
亚硝基磺酰氟是抗生素开发的新药效团单元
Corinne Sadlowski,Bora Park,Clarissa Araújo et al.
Corinne Sadlowski et al.
The development of antibiotics against Gram-negative bacteria is a central problem in drug discovery. In this report, we demonstrate that aromatic sulfonyl fluorides with a nitro group in their ortho position have remarkable antibacterial a...