Multi-site esterification: a tunable, reversible strategy to tailor therapeutic peptides for delivery [0.03%]
多点酯化反应：用于修饰治疗性肽以实现可控及可逆传递的策略
Mark S Bannon,Jeffrey F Ellena,Aditi S Gourishankar et al.
Mark S Bannon et al.
Peptides are naturally potent and selective therapeutics with massive potential; however, low cell membrane permeability limits their clinical implementation, particularly for hydrophilic, anionic peptides with intracellular targets. To ove...
Two conjectures on 3D Voronoi structures: a toolkit with biomedical case studies [0.03%]
关于三维Voronoi结构的两个猜想——具有生物医学案例研究工具包
Lucy Todd,Matthew H W Chin,Marc-Olivier Coppens
Lucy Todd
3D Voronoi scaffolds are widely applied in the field of additive manufacturing as they are known for their light weight structural resilience and share many topological similarities to various natural (bone, tumours, lymph node) and synthet...
Unexpected reversal of reactivity in organic functionalities when immobilized together in a metal-organic framework (MOF) [0.03%]
有机官能团固定在同一金属有机框架(MOF)中的意外活性反转现象
Pricilla Matseketsa,Donovan Mafukidze,Lahiru Pothupitiya et al.
Pricilla Matseketsa et al.
A mixed-ligand metal-organic framework (MOF) material composed of both amine- and hydroxyl-bearing linkers, KSU-1, was reacted with a variety of isocyanates. The hydroxyl groups reacted to a greater extent than the amines, in conflict with ...
Data-Driven Models for Predicting Intrinsically Disordered Protein Polymer Physics Directly from Composition or Sequence [0.03%]
直接从组成或序列预测内在无序蛋白质聚合物理的数据驱动模型
Tzu-Hsuan Chao,Shiv Rekhi,Jeetain Mittal et al.
Tzu-Hsuan Chao et al.
The molecular-level understanding of intrinsically disordered proteins is challenging due to experimental characterization difficulties. Computational understanding of IDPs also requires fundamental advances, as the leading tools for predic...
Patrik Tholen,Connor N Brown,Claudia Keil et al.
Patrik Tholen et al.
Herein, we report the crystal structure of 2,7-dichlorofluorescein methyl ester (DCF-ME) and its fluorescence response to hydroxyapatite binding. The reported fluorophore is very selective for staining the bone matrix and provides turn-on f...
Alignment and photooxidation dynamics of a perylene diimide chromophore in lipid bilayers [0.03%]
吸附在脂质双层中的苝二酰亚胺染料的取向和光氧化动力学研究
Novitasari Sinambela,Richard Jacobi,David Hernández-Castillo et al.
Novitasari Sinambela et al.
We present a method of enabling photochemical reactions in water by using biomimetic, water-soluble liposomes and a specifically functionalized perylene diimide chromophore. Linking two flexible saturated C4-alkyl chains with terminal posit...
Functionalisation of conjugated macrocycles with type I and II concealed antiaromaticity via cross-coupling reactions [0.03%]
一类和二类潜在反芳香性的共轭大环的衍生化反应
Troy L R Bennett,Adam V Marsh,James M Turner et al.
Troy L R Bennett et al.
Conjugated macrocycles can exhibit concealed antiaromaticity; that is, despite not being antiaromatic, under specific circumstances, they can display properties typically observed in antiaromatic molecules due to their formal macrocyclic 4n...
Engineered Protein-Iron Oxide Hybrid Biomaterial for MRI-traceable Drug Encapsulation [0.03%]
用于MRI可追踪药物封包的蛋白质-氧化铁混合生物材料
Lindsay K Hill,Dustin Britton,Teeba Jihad et al.
Lindsay K Hill et al.
Labeled protein-based biomaterials have become a popular for various biomedical applications such as tissue-engineered, therapeutic, or diagnostic scaffolds. Labeling of protein biomaterials, including with ultrasmall super-paramagnetic iro...
Hattie C Schunk,Mariah J Austin,Bradley Z Taha et al.
Hattie C Schunk et al.
Due to their N-substitution, peptoids are generally regarded as resistant to biological degradation, such as enzymatic and hydrolytic mechanisms. This stability is an especially attractive feature for therapeutic development and is a sellin...
Daniel A Paterson,Xiaoxue Du,Peng Bao et al.
Daniel A Paterson et al.
For a series of phospholipid coated calamitic nematic liquid crystal droplets (5CB, 6CB, 7CB, E7 and MLC7023) of diameter ∼18 μm, the addition of chiral dopant leaves the sign of surface anchoring unchanged. Herein we report that for thes...