Roberta Lock,Hadel Al Asafen,Sharon Fleischer et al.
Roberta Lock et al.
The convergence of tissue engineering and patient-specific stem cell biology has enabled the engineering of in vitro tissue models that allow the study of patient-tailored treatment modalities. However, sex-related disparities in health and...
Nebulized lipid nanoparticles [0.03%]
雾化脂质纳米粒
Christine Horejs
Christine Horejs
An article in Nature Biomedical Engineering reports an in vivo workflow for the design of lipid nanoparticles to efficiently deliver mRNA to the lungs via nebulization. ...
James P K Armstrong,Irene de Lázaro,Natalie J Kirkland et al.
James P K Armstrong et al.
Scientists have reacted to COVID-19 restrictions by organizing virtual seminars and journal clubs to maintain engagement. We reflect on our experiences and lessons learned from organizing such initiatives and highlight how, far from being t...
Taskeen Iqbal Janjua,Yuxue Cao,Chengzhong Yu et al.
Taskeen Iqbal Janjua et al.
Silica nanoparticles have entered clinical trials for a variety of biomedical applications, including oral drug delivery, diagnostics, plasmonic resonance and photothermal ablation therapy. Preliminary results indicate the safety, efficacy ...
Gillie A Roth,Vittoria C T M Picece,Ben S Ou et al.
Gillie A Roth et al.
Vaccines are the key technology to combat existing and emerging infectious diseases. However, increasing the potency, quality and durability of the vaccine response remains a challenge. As our knowledge of the immune system deepens, it beco...
Christine Horejs
Christine Horejs
Lipid nanoparticles are essential to mRNA vaccines. The groundwork for lipid-based drug delivery systems was laid more than 40 years ago in the lab of Pieter Cullis, Professor at the University of British Columbia. Nature Reviews Materials ...
Adam J Gormley,Michael A Webb
Adam J Gormley
The design of new functional polymers depends on the successful navigation of their structure-function landscapes. Advances in combinatorial polymer chemistry and machine learning provide exciting opportunities for the engineering of fit-fo...
Xucheng Hou,Tal Zaks,Robert Langer et al.
Xucheng Hou et al.
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent and treat various diseases. To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and...
Audrey K Bowden,Cullen R Buie
Audrey K Bowden
The experiences of Black scientists and engineers reveal that science is not a meritocracy. Here is a list of recommendations to combat anti-Black racism in academic institutions. ...
Zoë Ayres
Zoë Ayres
Good mental health and wellbeing of research staff and students lead to better science: it is time to reflect on what we can do as team leaders to create a positive research culture. ...