Intrinsic Cleavage of RNA Polymerase II Adopts a Nucleobase-independent Mechanism Assisted by Transcript Phosphate [0.03%]
RNA聚合酶II的内在切割采用由转录物磷酸基辅助的碱基无关机制
Carmen Ka Man Tse,Jun Xu,Liang Xu et al.
Carmen Ka Man Tse et al.
RNA polymerase II (Pol II) utilises the same active site for polymerization and intrinsic cleavage. Pol II proofreads the nascent transcript by its intrinsic nuclease activity to maintain high transcriptional fidelity critical for cell grow...