Associations of Obesity and Prognostic Nutritional Index on 1-Year Mortality in Patients with Acute Heart Failure [0.03%]
肥胖和预后营养指数与急性心力衰竭患者一年死亡率的关联研究
Mohammed El-Sheikh,Nora Olsen El Caidi,Aginsha Kandiah et al.
Mohammed El-Sheikh et al.
Background: Increased BMI is paradoxically associated with improved survival among patients with acute heart failure (AHF). However, the impact of different nutritional status on this obesity paradox on 1-year mortality i...
Frailty and Heart Failure: Clinical Insights, Patient Outcomes and Future Directions [0.03%]
虚弱与心力衰竭：临床见解，患者预后和未来方向
Karol Mirkowski,Ercole Vellone,Bernadetta Żółkowska et al.
Karol Mirkowski et al.
Frailty is common among heart failure (HF) patients and linked to increased risk of adverse outcomes. Contributing factors include inflammation, sarcopenia and neurohormonal issues which diminish physiological reserves and accelerate the de...
Counteracting the Mechanisms of Heart Failure is the Most Effective Way to Decongest Patients while Improving Outcomes [0.03%]
对抗心力衰竭的机制是缓解患者充血并改善预后的最有效方法
Jelena Čelutkienė,Alexandre Mebazaa,Jan Biegus et al.
Jelena Čelutkienė et al.
Diuretic therapy is not associated with improved outcomes in heart failure and may cause significant side effects. Counteracting the core pathophysiological mechanisms of heart failure through neurohormonal blockade while reducing reliance ...
Biomarkers for Congestion in Heart Failure: State-of-the-art and Future Directions [0.03%]
心力衰竭中充血的生物标志物：现状和未来方向
Antonio Luca Maria Parlati,Cristina Madaudo,Vincenzo Nuzzi et al.
Antonio Luca Maria Parlati et al.
Congestion in patients with heart failure (HF) predicts adverse outcomes and is a leading cause of hospitalisation. Understanding congestion mechanisms helps in HF management and underscores the importance of tailored therapies to treat vas...
Aldosterone and Potassium in Heart Failure: Overcoming This Major Impediment in Clinical Practice [0.03%]
盐皮质激素受体拮抗剂在心力衰竭治疗中钾管理和临床实践中的障碍
Laibah Arshad Khan,Adeena Jamil,Stephen J Greene et al.
Laibah Arshad Khan et al.
Aldosterone is a key regulator of fluid and electrolyte balance in the body. It is often dysregulated in heart failure (HF) and is a key driver of cardiac remodelling and worse clinical outcomes. Potassium regulation is essential for normal...
Dinesh Khullar,Anish Kumar Gupta,Kulwant Singh
Dinesh Khullar
Heart failure (HF) is a major contributor to hospitalisations and accounts for 7% of cardiovascular-related deaths, with patients who have chronic kidney disease and type 2 diabetes at heightened risk. Existing treatment guidelines inadequa...
Red Blood Cell Distribution Width as a Biomarker of Red Cell Dysfunction Associated with Inflammation and Macrophage Iron Retention: A Prognostic Marker in Heart Failure and a Potential Predictor for Iron Replacement Responsiveness [0.03%]
红细胞分布宽度作为与炎症和巨噬细胞铁滞留相关的红细胞功能障碍生物标志物：心力衰竭中的预后标志物及潜在的铁替代反应预测因子
Artemio García-Escobar,Rosa Lázaro-García,Javier Goicolea-Ruigómez et al.
Artemio García-Escobar et al.
Silvana Di Maio,Ritu Thamman,Julia Grapsa
Silvana Di Maio
Rishi Sethi,Pravesh Vishwakarma,Akshyaya Pradhan
Rishi Sethi
Activation of the renin-angiotensin-aldosterone system is the ultimate pathophysiological hallmark in heart failure. Though aldosterone primarily appears to regulate electrolyte homeostasis by acting on distal nephrons in the kidneys, its e...
Glucagon-like Peptide-1 Receptor Agonists in the Context of Pathophysiology of Diverse Heart Failure with Preserved Ejection Fraction Phenotypes: Potential Benefits and Mechanisms of Action [0.03%]
从不同射血分数保留型心力衰竭病理生理学的角度看肠促胰岛素类药物的作用及机制：潜在益处和作用机制
Aleksandra Bykova,Maria Serova,Maria Chashkina et al.
Aleksandra Bykova et al.
This review examines the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on different heart failure phenotypes with preserved ejection fraction (HFpEF). Traditional heart failure treatment modalities have shown limited succe...