Tyrosine kinase inhibitor associated vascular toxicity in chronic myeloid leukemia [0.03%]
慢性粒细胞白血病酪氨酸激酶抑制剂相关性血管毒性反应
Oren Pasvolsky,Avi Leader,Zaza Iakobishvili et al.
Oren Pasvolsky et al.
Tyrosine kinase inhibitors (TKIs) have revolutionized the management and outcomes of chronic myeloid leukemia (CML) patients. Improved disease control and prolonged life expectancy now mandate focus on improving TKIs' safety profile. Recent...
Michael S Ewer,Kalpesh Patel,Dennis O&#x;Brien et al.
Michael S Ewer et al.
Background: Afatinib is an oral irreversible ErbB family blocker that targets epidermal growth factor receptor (EGFR/ErbB1), human epidermal growth factor receptor 2 (HER2/ErbB2), and HER4 (ErbB4) and is approved for the ...
Cardiovascular co-morbidity in cancer patients: the role of psychological distress [0.03%]
癌症患者的心血管并发症状：心理压力的作用
Dounya Schoormans,Susanne S Pedersen,Susanne Dalton et al.
Dounya Schoormans et al.
Due to aging of the population and cardiotoxic cancer treatment, there is an increasing group of patients with cancer and co-morbid cardiovascular disease (CVD). In order to find a balance between the risk of undertreating the malignancy on...
Juvenile competitive triathlete after cardiotoxic anthracycline therapy for Acute Myeloid Leukemia [0.03%]
急性髓系白血病接受蒽环类心脏毒性治疗后的青少年竞技铁人三项运动员
Pia von Korn,Manfred Vogt,Renate Oberhoffer et al.
Pia von Korn et al.
Objective: The treatment of Acute Myeloid Leukemia (AML) leads to several functional limitations. Especially cardiac burden following cardiotoxic chemotherapy, which limits exercise and competitive sport in the long-term ...
Rationale for setting up a cardio-oncology unit: our experience at Mayo Clinic [0.03%]
建立心血管肿瘤科的必要性——梅奥诊所的经验
Sergio Barros-Gomes,Joerg Herrmann,Sharon L Mulvagh et al.
Sergio Barros-Gomes et al.
Background: The diagnosis and management of cardiovascular complications have become a clinical concern for oncologists, cardiologists, surgeons, interventional radiologists, radiation therapy physicians, internists, nurs...
A comparative assessment of coronary artery calcification on chest CT scans of patients referred to a cardio-oncology clinic [0.03%]
心脏肿瘤学门诊患者胸部CT冠状动脉钙化比较评估
Alison M Brann,Charlotte J Bai,John F Hibbeln et al.
Alison M Brann et al.
Background: The presence and burden of coronary artery calcium (CAC) is a strong predictor of cardiovascular events. In an effort to gain insight into the utility of CAC for coronary artery disease (CAD) screening in canc...
Steven E Lipshultz,Giorgio Minotti,Joseph Carver et al.
Steven E Lipshultz et al.
Effect of myocardial dysfunction in cardiac morbidity and all cause mortality in childhood cancer subjects treated with anthracycline therapy [0.03%]
阿霉素治疗的儿童癌症幸存者心脏功能障碍与疾病发病率和全因死亡率的关系
Olga H Toro-Salazar,Eileen Gillan,Joanna Ferranti et al.
Olga H Toro-Salazar et al.
Background: Subacute cardiotoxicity, consisting of acute myocyte damage and associated left ventricular dysfunction, occurs early during anthracycline therapy. We investigated the impact of myocardial dysfunction, defined...
Antonella De Angelis,Konrad Urbanek,Donato Cappetta et al.
Antonella De Angelis et al.
The cardiotoxicity of doxorubicin is becoming an interdisciplinary point of interest given a growing population of cancer survivors. The complex and not completely understood pathogenesis of this complication makes difficult to design succe...
Targeting endothelial cell metabolism for cardio-protection from the toxicity of antitumor agents [0.03%]
靶向内皮细胞代谢以对抗抗肿瘤药物毒性对心血管的保护作用
Lucia Morbidelli,Sandra Donnini,Marina Ziche
Lucia Morbidelli
The vascular endothelium plays a fundamental role in the maintenance of tissue homeostasis, regulating local blood flow and other physiological processes. Chemotherapeutic drugs and target therapies, including antiangiogenic drugs targeting...